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Heparin-Bead Extraction Enhanced Fluorogenic Aptamer–Thrombin Composite Reporter Enables Sensitive and Rapid Detection of Functional Antithrombin

Abstract Antithrombin (AT) deficiency in the extracorporeal circulation during cardiac surgery leads to uncontrolled inflammation and vascular damage in patients. AT levels decrease in sepsis, major trauma, extracorporeal membrane oxygenation,..

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Non-Contact Measurement of Blood Oxygen Saturation Using Facial Video Without Reference Values

Abstract The continuous measurement of percutaneous oxygen saturation (SpO2) enables diseases that cause hypoxemia to be detected early and patients’ conditions to be monitored. Currently, SpO2 is mainly measured using..

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Is it time for the death knell of single-unit plasma?

Abstract Background and Objectives A plasma transfusion dose should be weight-based (10–20 mL/kg), which equates to three to four units in an average-sized adult; therefore, the transfusion of single units under..

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Electrical impedance tomography during open heart surgery and on the cardiac icu is feasible to monitor ventilation in children with…

Abstract Alveolar de recruitment is a common problem during general anesthesia and operations. Pediatric cardiac surgery with cardiopulmonary Bypass is associated with interruption of ventilation and might enhance loss of..

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Variability and relative contribution of surgeon- and anesthesia-specific time components to total procedural time in cardiac surgery

Abstract Background Decreasing variability in time-intensive tasks during cardiac surgery may reduce total procedural time, lower costs, reduce clinician burnout, and improve patient access. The relative contribution and variability of..

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Year in review: tips for effective graduate medical education programme leadership and management

Abstract Programme leaders in graduate medical education (GME) are responsible for the final stage of physician training, guiding the transition from supervised to independent practice. The influence of GME programme..

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Impact of timing of urgent coronary artery bypass grafting following coronary angiography on acute kidney injury

Abstract Objectives Prior studies have examined the association between timing of cardiac surgery after  with risk of , but this remains controversial. The purpose of this study was to investigate the association..

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Associations Between Nonanemic Iron Deficiency and Postoperative Outcomes in Cardiac Surgery: A Systematic Review and Meta-Analysis

Abstract BACKGROUND: Preoperative screening for iron deficiency is a part of patient blood management protocols. This systematic review, meta-analysis, and meta-regression reviews the association between nonanemic iron deficiency and postoperative..

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A clinical comparison of glycol and water-based heater-cooler systems for cardiopulmonary bypass

Abstract Introduction While newer heater-cooler technologies using ethylene glycol-based (GB) solutions during cardiothoracic surgery have become commercially available, there is a paucity of clinical data describing their effectiveness during cardiopulmonary..

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Toward an Adjustable Blood Pump for Wide-Range Operation: In-Vitro Results of Performance Curve and Hydraulic Efficiency

Abstract Rotary blood pumps in Extracorporeal Life Support (ECLS) applications are optimized for a specific design point. However, in clinical practice, these pumps are usually applied over a wide range..

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Antepartum hemorrhage due to placenta previa with autologous transfusion: A case report

Abstract Introduction and importance Bleeding during pregnancy or during  can cause significant morbidity and mortality for the mother and baby, this can be overcome by performing a  (C-section) and . Although blood transfusions..

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Pediatric cardiac surgery: machine learning models for postoperative complication prediction

Abstract Purpose Managing children undergoing cardiac surgery with cardiopulmonary bypass (CPB) presents a significant challenge for anesthesiologists. Machine Learning (ML)-assisted tools have the potential to enhance the recognition of patients..

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POBS-Card, a new score of severe bleeding after cardiac surgery: Construction and external validation

Abstract Objective Bleeding after cardiac surgery leads to poor outcomes. The objective of the study was to build the PeriOperative Bleeding Score in Cardiac surgery (POBS-Card) to predict bleeding after..

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In vitro protamine addition for coagulation assessment using TEG 6s system during cardiopulmonary bypass: a pilot study

Abstract Objective Systemic heparinization during cardiopulmonary bypass (CPB) can significantly affect thromboelastography (TEG). This study investigated the feasibility of adding protamine in vitro to allow assessment of coagulation status using the..

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Evaluating the Use of Unfractionated Heparin with Intra-Aortic Balloon Counterpulsation

Abstract Background Evidence supporting  with unfractionated heparin (UFH) in patients with an intra-aortic balloon pump (IABP) to prevent  remains limited, while bleeding risks remain high. Monitoring heparin in this setting with anti-factor..

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Predictors of Mortality in Adults With Calcium Channel Blocker Toxicity Receiving Extra Corporeal Membrane Oxygenation Support: An Extracorporeal Life Support…

Abstract Calcium channel blocker (CCB) toxicity presents a significant mortality risk, highlighting the need for effective treatment strategies such as extracorporeal membrane oxygenation (ECMO). This study analyzes Extracorporeal Life Support..

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Definition and management of right ventricular injury in adult patients receiving extracorporeal membrane oxygenation for respiratory support using the Delphi…

Abstract Purpose: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an integral part of the management  algorithm of patients with severe respiratory failure refractory to evidence-based conventional treatments. Right  ventricular injury (RVI)..

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Megalin-related mechanism of hemolysis-induced acute kidney injury and the therapeutic strategy

Abstract Hemolysis-induced acute kidney injury (AKI) is attributed to heme-mediated proximal tubule epithelial cell (PTEC) injury and tubular cast formation due to intratubular protein condensation. Megalin is a multiligand endocytic..

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Evaluation of university and training standards in clinical perfusion, an European-wide survey

Abstract OBJECTIVES Adequate theoretical and practical training of prospective clinical perfusionists is essential for maintaining clinical standards and ensuring patient safety during cardiac surgery procedures. Perfusion schools play a crucial..

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First worldwide use of the hybrid system for extracorporeal circulation in heart transplant

Abstract Background This case report documents the first worldwide use of the Hybrid System from Spectrum Medical in a heart transplant procedure, focusing on its safety and efficacy. Traditional cardiopulmonary..

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Extracorporeal Membrane Oxygenation in Amniotic Fluid Embolism: A Systematic Review of Case Reports

Abstract Amniotic fluid embolism (AFE) is an obstetric complication that can result in acute circulatory failure during and after labor. The effectiveness of extracorporeal membrane oxygenation (ECMO) in AFE patients..

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Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation

Abstract Purpose: Patients receiving venoarterial extracorporeal membrane oxygenation (VA‑ECMO) frequently develop arte‑rial hyperoxaemia, which may be harmful. However, lower oxygen saturation targets may also lead to harmful episodes of hypoxaemia...

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Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in…

Abstract Data on perioperative extracorporeal membrane oxygenation (ECMO) in liver transplantation (LT) are scarce. ECMO has been used preoperatively, intraoperatively, and postoperatively for a variety of indications at our center...

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Early endothelial injury in cardiogenic shock patients on venoarterial ECMO

Abstract Endothelial injury is usually considered as a major com-ponent of the systemic inflammatory response observed during veno-arterial extracorporeal membrane oxygena-tion (VA-ECMO) support [1, 2]. Yet, few data are avail-able..

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Outcome, compliance with inclusion criteria and cost of extracorporeal cardiopulmonary resuscitation (ECPR) in out-of-hospital cardiac arrest: A retrospective cohort study

Abstract Introduction The primary aim was to describe the outcome, the compliance with inclusion criteria and the characteristics of patients who underwent extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest..

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Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL…

Abstract Extracorporeal membrane oxygenation (ECMO) is a high-risk and low-volume life support with increasing clinical study. However, heterogenous outcome definitions impede data assimilation into evidence to guide practice. The Academic..

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Heart Transplantation and Left Ventricular Assist Devices: Long-Term Prognosis and Effects on Mental Health

Abstract Heart transplantation and left ventricular assist devices (LVADs) have emerged as crucial interventions for end-stage heart failure, dramatically improving patient outcomes. This narrative review examines their historical context, indications,..

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Extracorporeal cardiopulmonary resuscitation for pediatric out-of-hospital cardiac arrest: A review of the Extracorporeal Life Support Organization Registry

Abstract Aims Current data are insufficient for the leading resuscitation societies to advise on the use of extracorporeal cardiopulmonary resuscitation (ECPR) for pediatric out-of-hospital cardiac arrest (OHCA). The aim of..

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Temporal trends in organ donation among cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation

Abstract Aims This study explores the evolution of organ donation from patients treated with extracorporeal-cardiopulmonary-resuscitation (ECPR) for refractory out-of-hospital-cardiac-arrest (OHCA) and evaluates the public health benefits of a mature ECPR..

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The Relationship Between Transfusion in Cardiac Surgery Patients and Adverse Outcomes

Abstract Objectives To understand if red blood cell (RBC) transfusions are independently associated with a risk of mortality, prolonged , or infectious, cardiac, or renal morbid outcomes. Design A retrospective review...

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