Abstract Objective To review and compare the frequency of thrombus and adverse events in patients treated with heparin or bivalirudin systemic anticoagulation strategies supported on combined venoarterial extracorporeal membrane oxygenation..
Read MoreAbstract Background Veno‑venous extracorporeal membrane oxygenation (VV‑ECMO) is associated with a high transfusion burden. While trials have concluded that red blood cell (RBC) storage does not impact patient morbidity and..
Read MoreAbstract There are conflicting clinical data on whether the use of a distal perfusion catheter (DPC) is beneficial for reducing the risk of limb ischemia in peripheral venoarterial extracorporeal membrane..
Read MoreAbstract Heparin, a high alert anticoagulant medication, is commonly used in medical settings in preventing and treating thrombotic events. However, its administration carries inherent risks for medication errors, bleeding complications..
Read MoreAbstract Purpose The evidence supporting the benefit on clinical outcomes of prone positioning during veno-venous extracorporeal membrane oxygenation (V-V ECMO) for acute hypoxemic respiratory failure remains inconclusive. We aimed to..
Read MoreAbstract The storing of dry-assembled and primed extracorporeal membrane oxygenation (ECMO) circuits is common practice and endorsed by the Extracorporeal Life Support Organization (ELSO) for up to 30 days. We..
Read MoreAbstract Introduction & aim Intraoperative adverse events (iAEs) increase postoperative complications, which are devastating to patients and costly to healthcare systems. To optimise patient outcomes, the WHO Surgical Safety Checklist (WHO..
Read MoreAbstract Objectives To summarize evidence regarding intravenous angiotensin II administration in critical illness and provide an updated understanding of its effects on various organ dysfunction and renin-angiotensin system (RAS) biomarkers...
Read MoreAbstract Objective The use of an intra-aortic balloon pump (IABP) has been suggested to unload the left ventricle while on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock (CS), leading..
Read MoreAbstract Extracorporeal membrane oxygenation (ECMO) traditionally has been used under deep sedation and mechanical ventilation. However, recent advancements have led to the development of awake ECMO strategies, allowing patients to..
Read MoreAbstract Introduction: In life-threatening conditions like severe acute respiratory distress syndrome (ARDS), rescue interventions like extracorporeal membrane oxygenation (ECMO) should be initiated urgently to resolve an otherwise potentially adverse clinical outcome...
Read MoreAbstract Donation after circulatory death (DCD) is driving the increase in deceased organ donors in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been..
Read MoreAbstract In neonates with pulmonary hypertension (PH) supported on veno-venous extracorporeal membrane oxygenation (VV-ECMO), keeping the ductus arteriosus (DA) open ensures a high cardiac output of well-oxygenated blood through the..
Read MoreAbstract Venovenous extracorporeal membrane oxygenation is the most commonly used mode of support in pre-lung transplant recipients. In patients who experience right ventricular dysfunction, venopulmonary ECMO is an excellent option..
Read MoreAbstract Objectives: Previous studies have shown that inaccurate peripheral oxygen saturation (SpO2) readings compared with arterial oxygen saturation (SaO2) may occur in extracorporeal membrane oxygenation (ECMO) patients. We hypothesized that..
Read MoreAbstract Purpose: The Placenta Accreta Spectrum (PAS) poses a significant obstetric challenge, often leading to life-threatening hemorrhage during delivery. Intraoperative Cell Salvage (IOCS) is a promising but insufficiently studied blood conservation..
Read MoreAbstract The operating room is often viewed as a high-stakes, technical, and intensely specialized environment. While clinical precision and technological advancements have greatly improved surgical outcomes, one critical element remains..
Read MoreAbstract Protamine is widely used after catheter ablation to achieve hemostasis. Anaphylaxis to protamine is a rare but severe complication. A 49-year-old male patient underwent catheter ablation of symptomatic long-standing..
Read MoreAbstract Introduction Cardiac arrest in the emergency department (ED) is a rare event. Prior studies have used dedicated cardiac arrest registries, but few have leveraged “big data” from electronic healthcare..
Read MoreAbstract We established a compact machine perfusion system for whole blood perfusion of rat liver by making use of oxygenation filters as an artificial lung. Livers removed from rats were..
Read MoreAbstract Rationale: Randomised clinical trials in intensive care often prioritize disease-focused outcomes rather than patient-centred outcomes. Objective: To report and evaluate the ‘Daily Organ Support for patients on extracorporeal membrane..
Read MoreAbstract Oxygen is crucial for mitochondrial energy production in neurons and is efficiently stored and transported within the hydrophobic core of phospholipid bilayers. Using a diffusive model derived from molecular..
Read MoreAbstract Background Venoarterial extracorporeal membrane oxygenation (V-A ECMO) use to support patients in cardiac failure is increasing. Despite this increased use, predicting successful weaning from ECMO can be challenging, no..
Read MoreAbstract Introduction Congenital cardiac defects disrupt circulation and oxygenation due to structural changes in the heart. Tetralogy of Fallot is the most common cyanotic congenital heart disease, accounting for 5..
Read MoreAbstract Objective Cardiac arrest happens in 0.7%-5.2% patients after cardiovascular surgery, and cases with asystole or severe bradycardia need timely temporary pacing. However, routine temporary pacing wire insertion in cardiopulmonary..
Read MoreAbstract Purpose Neonates undergoing cardiopulmonary bypass (CPB) are at a high risk of a systemic inflammatory response leading to cardiac, respiratory, and renal dysfunction due to their small body size..
Read MoreAbstract Objective This study aims to evaluate the operational feasibility of a self-designed minimally invasive extracorporeal circulation integrated circuit (miECC) type IV system and to assess the effectiveness of the..
Read MoreAbstract Background: Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are widely used. Previous methods to reduce inflammation have shown inconsistent results. We developed a cytokine adsorption column using polymethyl methacrylate..
Read MoreAbstract Background Cardiac surgery is associated with increased risk of major adverse outcomes. Venous to arterial carbon dioxide tension gap (Pv-aCO2 gap) showed significant prognostic value of non-cardiac surgery, while their..
Read MoreAbstract Background Evidence for the effectiveness of the Sonoclot analyzer in improving clinical outcomes in disseminated intravascular coagulation (DIC) is lacking. Objective To evaluate the effectiveness of an algorithm based..
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