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Agreement Between the TEG 6s and TEG 5000 Analyzers in Extracorporeal Membrane Oxygenation

Abstract Thromboelastography (TEG) evaluates viscoelastic properties of blood clot formation. The TEG 5000 analyzer is commonly used but prone to errors related to vibration or operator error. The TEG 6s..

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Cerebral oxygenation and autoregulation during rewarming on cardiopulmonary bypass

Abstract Background Rewarming on cardiopulmonary bypass (CPB) is associated with increased metabolic demands; however, it remains unclear whether cerebral autoregulation is affected during this phase. This RCT aims to describe..

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Focused educational intervention improves intern knowledge of perioperative patient blood management principles

Abstract A perioperative patient blood management (PBM) educational intervention was implemented for first year postgraduate doctors (interns) at the Royal Brisbane and Women’s Hospital (RBWH) following identification of a perioperative..

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Independent Predictors of Postoperative Stroke With Cardiopulmonary Bypass

Abstract Objective To assess predictive factors of postoperative stroke in cardiac surgery using cardiopulmonary bypass (CPB). Design This study was a retrospective observational study. Setting This study was conducted at..

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Impact of Early, Low-Dose Factor VIIa on Subsequent Transfusions and Length of Stay in Cardiac Surgery

Abstract Objective Recombinant factor VII (rFVIIa) is used to treat cardiac surgical bleeding in an off-label manner. However, optimal dosing and timing of administration to provide efficacious yet safe outcomes..

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Prothrombin complex concentrates in cardiac surgery: where are we?

Abstract Purpose of review  Major bleeding in cardiac surgery is commonly encountered, and, until recently, most frequently managed with fresh frozen plasma (FFP). However, a Cochrane review found this practice..

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Perioperative Care Standards in Cardiac Surgery Patients Aiming at Enhancing Recovery: A Nationwide Survey in the Netherlands and Belgium

Abstract Objective The aim of this survey was to describe existing  standards and best practices in the Netherlands and Belgium. Design An online survey was followed up by an in-depth personal..

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Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a…

Abstract Purpose Previous studies support the potential efficacy of venovenous extracorporeal membrane oxygenation (vvECMO) for improving survival in severe acute respiratory distress syndrome (ARDS) cases. Prone positioning (PP) has been..

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Transfusion thresholds for guiding red blood cell transfusion

Abstract Background The optimal haemoglobin threshold for use of red blood cell (RBC) transfusions in anaemic patients remains an active field of research. Blood is a scarce resource, and in some countries,..

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The influence of intra-aortic balloon counter pulsation on central venous blood oxygen saturation

Abstract Objectives We aim at identifying the changes in venous blood saturation values that associates intra-aortic balloon pump (IABP) in cardiac surgery patients with reduced left ventricular function (LVF). Methods..

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Making transfusion medicine a journey from good to great by using quality indicators and bringing in continuous quality improvement

Abstract From its foundational years, transfusion medicine (TM) has been associated with errors and their reporting. Patient safety and quality were brought to the forefront of health care through the..

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Vacuum-assisted venous drainage, angel or demon: PRO?

Abstract Vacuum-assisted venous drainage (VAVD) was proposed to optimize venous drainage during bypass through femoral venous cannulation. It is currently used in both adult and pediatric surgery when siphon gravity..

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Percutaneous versus surgical cannulation for femoro-femoral VA-ECMO in patients with cardiogenic shock: results from the Extracorporeal Life Support Organization Registry

Abstract Purpose Percutaneous cannulation is increasingly used for veno-arterial extracorporeal membrane oxygenation (VA-ECMO). However, there is limited evidence about the benefit of this approach compared with conventional surgical cannulation. By..

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Resuscitation Using ECPR During In-Hospital Cardiac Arrest (RESCUE-IHCA) Mortality Prediction Score and External Validation

Abstract Objectives The aim of this study was to develop and validate a score to accurately predict the probability of death for adult extracorporeal cardiopulmonary resuscitation (ECPR). Background ECPR is..

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Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation

Abstract Objectives:  To investigate platelet pathophysiology associated with pediatric extracorporeal membrane oxygenation (ECMO). Design:  Prospective observational study of neonatal and pediatric ECMO patients from September 1, 2016, to December 31,..

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Preoperative anaemia and outcome after elective cardiac surgery: a Dutch national registry analysis

Abstract Background Previous studies have shown that preoperative anaemia in patients undergoing cardiac surgery is associated with . However, most of these studies were retrospective, had a relatively small sample size,..

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Impella as unloading strategy during VA-ECMO: systematic review and meta-analysis

Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used as mechanical circulatory support in cardiogenic shock (CS). It restores peripheral perfusion, at the expense of increased left ventricle (LV) afterload. In..

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Defining vasoplegia following durable, continuous flow left ventricular assist device implantation

Abstract This study aimed to develop a definition of vasoplegia that reliably predicts clinical outcomes. Vasoplegia was evaluated using data from the electronic health record for each 15-minute interval for..

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Role of Platelets in Acute Lung Injury after Extracorporeal Circulation in Cardiac Surgery Patients: A systemic review

Abstract In vitro circulation (cardiopulmonary bypass, CPB) has been widely used in heart surgery. In the past, it was believed that the reduction of platelet count and impaired platelet function..

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Efficacy of Pulsatile Flow Perfusion in Adult Cardiac Surgery: Hemodynamic Energy and Vascular Reactivity

Abstract Background: The role of pulsatile (PP) versus non-pulsatile (NP) flow during a cardiopulmonary bypass (CPB) is still debated. This study’s aim was to analyze hemodynamic effects, endothelial reactivity and erythrocytes..

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The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats

Abstract Introduction Cardiopulmonary bypass (CPB) –induced lung ischemia-reperfusion (I/R) injury remains a large challenge in cardiac surgery; up to date, no effective treatment has been found. Annexin A1 (AnxA1) has..

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A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance

Abstract Objectives The assessment of platelet function in cardiac surgery patients who recently received dual-antiplatelet therapy is considered in the existing guidelines. Among available devices, Multiplate (MP) and ROTEM Platelet..

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University of Maryland School of Medicine Faculty Scientists and Clinicians Perform Historic First Successful Transplant of Porcine Heart into Adult…

In a first-of-its-kind surgery, a 57-year-old patient with terminal heart disease received a successful transplant of a genetically-modified pig heart and is still doing well three days later. It was..

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Use of the CardioHELP Device for Temporary Hemodynamic Support During High-Risk Percutaneous Coronary Intervention

Abstract Background.  Temporary extracorporeal membrane oxygenation (ECMO) support for high-risk percutaneous coronary intervention (PCI) has been described in select patients, and data are limited on the CardioHELP device (Maquet). The..

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Subclavian Versus Femoral Arterial Cannulations During Extracorporeal Membrane Oxygenation: A Propensity-Matched Comparison

Abstract Background During peripheral extracorporeal veno-arterial membrane oxygenation (VA-ECMO) support, subclavian arterial cannulation provides, in comparison to femoral arterial cannulation, an anterograde flow which may prevent from left ventricular (LV)..

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Targeted temperature management in cardiac surgery: a systematic review and meta-analysis on postoperative cognitive outcomes

Abstract Background Postoperative cognitive decline occurs commonly after cardiac surgery. The available literature is inconclusive on the role of intraoperative causal or protective factors. Methods We systematically reviewed studies evaluating..

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Antithrombin III infusion improves anticoagulation in congenital diaphragmatic hernia patients on extracorporeal membrane oxygenation

Abstract Purpose Achieving effective anticoagulation during neonatal extracorporeal membrane oxygenation (ECMO) without increasing the risk of hemorrhage remains challenging. The use of antithrombin III (AT-III) for this purpose has been..

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The dynamics of cavitation bubbles in a sealed vessel

Abstract A model of cavitation bubbles is derived in liquid confined in an elastic sealed vessel driven by ultrasound. In this model, an assumption that the pressure acting on the..

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How to best monitor bivalirudin anticoagulant effect for ECMO and VAD—Comparison of four assay methods

Abstract Introduction Unfractionated heparin is widely used as an anticoagulant for extracorporeal life support (ECLS) and usually monitored with activated partial thromboplastin time (aPTT). Due to its limitations in pediatric..

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Hyperglycemia and Thrombocytopenia ― Combinatorially Increase the Risk of Mortality in Patients With Acute Myocardial Infarction Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation

Abstract Background:Patients with cardiogenic shock due to acute myocardial infarction (AMI) can rapidly undergo veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy to recover cardiac output and decrease mortality. However, the clinical..

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