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The impact of iron store on red blood cell transfusion: a multicentre prospective cohort study in cardiac surgery

Abstract Background Anaemia is common prior to cardiac surgery and contributes to perioperative morbidity. Iron deficiency is the main cause of anaemia but its impact remains controversial in the surgical..

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Absorbable sutures for cardiopulmonary bypass purse strings in pediatric heart surgery

Abstract Background Absorbable sutures, commonly used in general surgery, are not routinely used as purse strings for arterial and venous cannulation for cardiopulmonary bypass in pediatric heart surgery. The general concern..

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The role of the ADVanced Organ Support (ADVOS) system in critically ill patients with multiple organ failure

Abstract Background Multi-organ failure characterized by acute kidney injury, liver dysfunction, and respiratory failure is a complex condition associated with high mortality, for which multiple individual support devices may be..

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Long-Term Follow-Up of Survivors of Extracorporeal Life Support Therapy for Cardiogenic Shock: Are They Really Survivors?

Abstract Background and Objectives:  Cardiogenic shock (CS) is a medical emergency associated with a high mortality rate. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has become an accepted therapy for CS. Despite..

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Extracorporeal Membrane Oxygenation in Pregnant Women With COVID-19

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and lung involvement is common. Patients with COVID-19 may progress to acute respiratory distress syndrome..

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Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery: A Randomized Trial

Abstract BACKGROUND:  Vasopressors are a cornerstone for the management of vasodilatory hypotension. Vasopressor infusions are currently adjusted manually to achieve a predefined arterial pressure target. We have developed a closed-loop..

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Systemic inflammatory response during cardiopulmonary bypass: Axial flow versus radial flow oxygenators

Abstract Background: The objective of this study was to investigate the inflammatory effects of different oxygenator flow pattern types in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass...

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A Randomized Clinical Trial of Perfusion Modalities in Pediatric Congenital Heart Surgery Patients

Abstract Background The objective of this randomized clinical trial was to investigate the effects of perfusion modalities on cerebral hemodynamics, vital organ injury, quantified by the Pediatric Logistic Organ Dysfunction-2..

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Chlorhexidine bathing of the exposed circuits in extracorporeal membrane oxygenation: an uncontrolled before-and-after study

Abstract Background Although the prevention of extracorporeal membrane oxygenation (ECMO) catheter-related infection is crucial, scientific evidence regarding best practices are still lacking. Methods We conducted an uncontrolled before-and-after study to..

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A Patient-Tailored Approach to Management of Acute Limb Ischemia in Patients with COVID-19: A Case Series

Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) has a tremendous impact on the respiratory tract. In severe COVID-19 infections, patients may experience shock and multiple organ failure. We described 4 cases of..

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A Global Definition of Patient Blood Management

Abstract While patient blood management (PBM) initiatives are increasingly adopted across the globe as part of standard of care, there is need for a clear and widely accepted definition of..

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Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis

Abstract Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a..

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Blood pressure variability during pediatric cardiac surgery is associated with acute kidney injury

Abstract Background Blood pressure variability (BPV), defined as the degree of variation between discrete blood pressure readings, is associated with poor outcomes in acute care settings. Acute kidney injury (AKI)..

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Evaluation of Minnesota Score in the Allocation of Venovenous Extracorporeal Membrane Oxygenation During Resource Scarcity

Abstract Background. In this study, we evaluate the previously reported novel Minnesota Score for association with in-hospital mortality and allocation of venovenous extracorporeal membrane oxygenation in patients with acute respiratory..

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Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly

Abstract Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect..

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The results of cardiac surgery during the COVID-19 pandemic compared with previous years: a propensity weighted study of outcomes at…

Abstract Objectives In addition to excess mortality due to COVID-19, the pandemic has been characterised by excess mortality due to non-COVID diagnoses and consistent reports of patients delaying seeking medical..

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A novel autotransfusion device saving erythrocytes and platelets used in a 72 h survival swine model of surgically induced controlled…

Abstract Background The purpose of this study was to develop a swine model of surgically induced blood loss to evaluate the performances of a new autotransfusion system allowing red blood..

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Extensive cell salvage and postoperative outcomes following thoracoabdominal and descending aortic repair

Abstract Objective Cell salvage (CS) reduces intraoperative . However, it may cause deformity of the red blood cells and loss of , which may lead to unwanted . Thus, we hypothesized that extensive..

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Association of Intraoperative Transesophageal Echocardiography and Clinical Outcomes After Open Cardiac Valve or Proximal Aortic Surgery

Abstract Importance  Intraoperative transesophageal echocardiography (TEE) is used frequently in cardiac valve and proximal aortic surgical procedures, but there is a lack of evidence associating TEE use with improved clinical outcomes...

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Goal-directed perfusion for reducing acute kidney injury in cardiac surgery: A systematic review and meta-analysis

Abstract Background Acute kidney injury (AKI) is a common complication following cardiopulmonary bypass (CPB) which can affect morbidity and mortality. Goal-directed perfusion (GDP) intended to avoid the nadir oxygen delivery..

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Early experience with the Impella pump: Single-center registry

Abstract Background: With the rapid development of mechanical circulatory support technologies, patients presenting with cardiogenic shock have gained access to various treatment opportunities which were not until recently available. The Impella®..

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Major Bleeding and Thromboembolic Events in Veno-Venous Extracorporeal Membrane Oxygenation-Patients With Isolated Respiratory Failure

Abstract Bleeding and thromboembolic events are common during veno-venous extracorporeal membrane oxygenation (vvECMO). It is unknown whether these complications are driven by the ECMO system itself, multiorgan-failure, or both. The..

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Is body surface area still the best way to determine pump flow rate during cardiopulmonary bypass?

Abstract For over four decades, pump flow rate during cardiopulmonary bypass (CPB) has been estimated using body surface area (BSA). As patients presenting for heart surgery are increasingly obese, this..

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Analysis of Burkholderia cepacia Outbreak From Contaminated Extracorporeal Membrane Oxygenation Water Heaters

Abstract A cluster of hospital-acquired Burkholderia cepacia complex infections was found to be attributed to contaminated extracorporeal membrane oxygenation (ECMO) water heaters. These findings were published in Clinical Infectious Diseases. In December of 2020,..

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Fifty Things a Cardiac Surgery Team Can Do for Blood Conservation

Abstract The transfusion of autologous blood remains a potentially controllable complication of open-heart surgery. The most important element in a blood conservation program is an attitude on the part of..

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Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery

Abstract Major blood loss remains common in cardiac surgery with an incidence of up to 15%. Bleeding leads to anemia and blood product transfusion, and can lead to the need..

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The Sword of Damocles: Family Presence and Extracorporeal Life Support During The COVID-19 Pandemic and Beyond

Abstract During Ontario’s busiest surge of COVID-19 (coronavirus disease) to date, our Pediatric ICU at the Hospital for Sick Children (normally an entirely pediatric referral centre) admitted adult patients under..

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Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation With and Without Intra-Aortic Balloon Pump

Abstract Objectives To compare the outcomes of patients with postcardiotomy shock treated with venoarterial  (VA-ECMO) only compared with VA-ECMO and intra-aortic balloon pump (IABP). Design A retrospective multicenter registry study. Setting..

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Use of VA-ecmo as opposed to CPB in pre treatment

Abstract This is a summary of a case study entitled “Surgical pulmonary embolectomy on VA-ECMO” reported by Rachel Steinhorn, Adam A. Dalia, Edward A. Bittner, and Marvin G. Chang analyzing the..

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Clinical evaluation of the novel Capiox NX19 adult oxygenator–a multicenter study

Abstract Introduction The novel Capiox NX19 adult oxygenator is, compared to its predecessors, improved with enhanced air removal technology, a polymer heat exchanger and smaller, innovative hollow fibers resulting in..

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