At the time of writing this editorial, I have been in health care for exactly 45 years. These years have taken me through many challenging settings, including intensive cares, emergency departments, operating rooms, acute and chronic care wards, therapy/outpatient clinics and land/air transport teams, etc., etc. Over that time, I learned so much from so many. But, there has always been one aspect of clinical practice in all these settings that has always left me wondering why. That practice is the ambivalence around removing air bubbles from an intravenous (IV) line beforeit enters the patient’s venous circulation.