Anaphylactic reactions are potentially serious systemic responses, either immunologic or nonimmunologic, that are typically rapid in onset, of variable severity, responsive to the timely administration of epinephrine, and rarely cause death [1]. Severe anaphylaxis is characterised by the compromise of breathing and/or circulation and most often, but not always, progresses from and is preceded by milder signs/symptoms [2]. There is some genetic tendency and individual distinction involved in these reactions [3]. Human fibrinogen (FIB) preparations are derived from the plasma of healthy individuals through a process that includes separation, purification, viral inactivation, and lyophilisation. The infusion of human FIB corrects hypofibrinogenemia and improves coagulation function disorder [4]. However, sporadic instances of adverse allergic reactions to it have been documented. Detailed below is such a case, marked by a severe allergic reaction precipitated by human FIB infusion.