Yearly Archives: 2024

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Successful Nafamostat Mesilate Administration for Andexanet Alfa-Induced Heparin Resistance

Abstract Andexanet alfa is an analog of activated factor X and is used as an antagonist of anti-activated factor X agents. Andexanet alfa is useful for hemostasis in emergent bleeding..

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Cardiac tamponade complicating extracorporeal membrane oxygenation: an Extracorporeal Life Support Organization Registry analysis.

Abstract Objectives  is a potentially life-threatening complication during  (ECMO). In this study, we assessed the incidence, , and risk factors for mortality of cardiac tamponade during ECMO. Design We queried the  Organization (ELSO)..

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Follow-up for More than 10 Years of Patients with Peritoneal Metastases Treated with Cytoreductive Surgery + Hyperthermic Intraperitoneal Chemotherapy in…

Abstract Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have demonstrated their impact on disease-free survival (DFS) and overall survival (OS) of patients with peritoneal metastases (PM). However, prior literature..

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Impact of CytoSorb Hemoadsorption Therapy on Fluid Balance in Patients with Septic Shock

Abstract Recent in vitro studies have investigated the effects of hemoadsorption therapy on endothelial function in sepsis showing a reduction in markers of endothelial dysfunction, but, to this day, there..

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A Decrease in Effective Renal Perfusion Pressure Is Associated With Increased Acute Kidney Injury in Patients Undergoing Cardiac Surgery

Abstract Purpose: This study aimed to evaluate the relationship between intra-abdominal pressure (IAP), renal perfusion indices, and postoperative acute kidney injury (AKI) in cardiac patients. Methods: In a prospective cohort..

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Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Abstract Blood oxygenators are used to saturate oxygen levels and remove carbon dioxide from the body during cardiopulmonary bypass. Although the natural lung is hydrophilic, commercially used oxygenator materials are..

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Dose Effect of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass

Abstract Background Neurologic impairments are a significant concern for survivors after  cardiac surgery with  (CPB). We have previously shown that mesenchymal stromal cell (MSC) delivery through CPB has the potential to mitigate the effects..

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Gaseous Micro-Embolic Activity and Goal-Directed Perfusion Management in a Closed System for Cardiopulmonary Bypass and Minimally Invasive Extracorporeal Circulation during…

Abstract Background: Cardiopulmonary bypass (CPB) techniques are becoming minimally invasive in clinical practice. The literature describes various extracorporeal techniques which seek to eliminate air-blood contact and reduce both hemodilution and the..

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Appropriate timing of veno‑arterial extracorporeal membrane oxygenation initiation after cardiac surgery

Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can be initiated during cardiac surgery or later in ICU according to the hemodynamic profile and organ perfusion. Our aim was to study..

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Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies

Abstract Purpose: Cardiogenic shock is associated with high mortality. In refractory shock, it is unclear if mechanical circulatory support (MCS) devices improve survival. We conducted a network meta-analysis to determine..

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Influenza Season and Outcome After Elective Cardiac Surgery: An Observational Cohort Study

Abstract Background An asymptomatic  during cardiac surgery could lead to pulmonary complications and increased mortality. For , testing for  before surgery or vaccination could reduce the number of these pulmonary complications. The aim..

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Institutional Variability in Red Blood Cell Transfusion With Coronary Bypass in a Statewide Database

Abstract Background The decision to perform transfusion is common but varies among centers and surgeons. This study looked at variables associated with red blood cell (RBC) transfusion in a statewide..

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Factor XI Inhibition With Heparin Reduces Clot Formation in Simulated Pediatric Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) supplies circulatory support and gas exchange to critically ill patients. Despite the use of systemic anticoagulation, blood exposure to ECMO surfaces causes thromboembolism complications. Inhibition..

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Adult Highlights From the Extracorporeal Life Support Organization Registry: 2017–2022

Abstract The Extracorporeal Life Support Organization (ELSO) registry captures clinical data and outcomes on patients receiving extracorporeal membrane oxygenation (ECMO) support across the globe at participating centers. It provides a..

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Ten things that nurses should know about ECMO

Abstract Venovenous extracorporeal membrane oxygenation (VVECMO) is a potent salvage therapy for ARDS patients who remain severely hypoxemic despite the use of more conventional treatments. In a study done in..

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Veno-arterial extracorporeal membrane oxygenation as a perioperative support to redo cardiac surgery for inoperable adult patients: a case series

Abstract Background The present article describes three cases of patients in cardiogenic shock (CS) with previous cardiac surgery that made them initially inoperable. Perioperative support with veno-arterial extracorporeal membrane oxygenation..

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Novel Left Ventricular Unloading Strategies in Patients on Peripheral Venoarterial Extracorporeal Membrane Oxygenation Support

Abstract The purpose of this study was to evaluate left ventricular (LV) unloading strategies in patients supported with peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). A retrospective review was conducted of..

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Long-term outcomes of patients supported with extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis

Abstract Background Extracorporeal membrane oxygenation (ECMO) is increasingly used to support patients with severe acute respiratory distress syndrome (ARDS). The impact of ECMO on long-term outcomes of patients with severe..

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Left-Ventricular Unloading With Impella During Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis

Abstract Objectives:  Extracorporeal cardiopulmonary resuscitation (ECPR) is the implementation of venoarterial extracorporeal membrane oxygenation (VA-ECMO) during refractory cardiac arrest. The role of left-ventricular (LV) unloading with Impella in addition to..

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Contemporary management of major haemorrhage in critical care

Abstract Haemorrhagic shock is frequent in critical care settings and responsible for a high mortality rate due to multiple organ dysfunction and coagulopathy. The management of critically ill patients with..

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Virtual reality simulation as a training tool for perfusionists in extracorporeal circulation: Establishing face and content validity

Abstract Objective We conducted a prospective study to assess the face and content validity of a new virtual reality (VR) extracorporeal circulation simulator (ECC) developed for perfusionists to facilitate training..

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Blend to Limit Oxygen in ECMO: A RanDomised ControllEd Registry (BLENDER) Trial: Study Protocol and Statistical Analysis Plan

Abstract Introduction Critically ill patients supported with venoarterial  (VA ECMO) are at risk of developing severe arterial , which has been associated with increased mortality. Lower saturation targets in this population may..

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Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights

Abstract Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass (CPB) may develop several biochemical changes in the microcirculation that lead to a systemic inflammatory response. Surgical incision, post-CPB..

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NO Addition during Gas Oxygenation Reduces Liver and Kidney Injury during Prolonged Cardiopulmonary Bypass

Abstract Objective. To evaluate the effect of NO added to the sweep gas of the oxygenator during cardiopulmonary bypass (CPB) on the liver and kidneys in pigs.  Methods. An experiment..

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Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review

Abstract Purpose Cold-stored platelets (CSP) are an increasingly active topic of international research. They are maintained at 1–6 °C, in contrast to standard room-temperature platelets (RTP) kept at 20–24 °C. Recent evidence..

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Neurologic Statistical Prognostication and Risk Assessment for Kids on Extracorporeal Membrane Oxygenation—Neuro SPARK

Abstract This study presents Neuro-SPARK, the first scoring system developed to assess the risk of neurologic injury in pediatric and neonatal patients on extracorporeal membrane oxygenation (ECMO). Using the extracorporeal..

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Simultaneous upper and lower body perfusion using hypothermia during thoracoabdominal aortic surgery

Abstract Background In open thoracoabdominal aortic aneurysm (TAAA) repair, we have been performing vascular reconstruction under moderate to deep hypothermia and assisted circulation using simultaneous upper and lower body perfusion...

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Carboxyhemoglobin and Methemoglobin Levels and Hemolysis in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Abstract Hemolysis is a complication of cardiopulmonary bypass (CPB). Carboxyhemoglobin (COHb) and methemoglobin (MetHb) were suggested as potential hemolysis biomarkers. This retrospective study was based on a prospective registry aimed..

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Early outcome of simplified total arch reconstruction under mild hypothermia (30–32 °C) with distal aortic perfusion

Abstract Objective We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32 °C) with distal aortic perfusion. This study aimed to compare its efficacy..

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CheckPOINT: a simple tool to measure Surgical Safety Checklist implementation fidelity

Abstract Introduction The WHO Surgical Safety Checklist (SSC) is a communication tool that improves teamwork and patient outcomes. SSC effectiveness is dependent on implementation fidelity. Administrative audits fail to capture most..

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