Yearly Archives: 2023

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The perioperative use of inhaled prostacyclins in cardiac surgery: a systematic review and meta-analysis

Abstract Purpose Perioperative pulmonary hypertension (PH) is an independent risk factor for morbidity and mortality in cardiac surgery. While inhaled prostacyclins (iPGI2s) are an established treatment of chronic PH, data..

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Effect of Albumin Usage during Cardiopulmonary Bypass on Postoperative Acute Kidney Injury in Cardiac Surgery Patients: A Historical Cohort Study

Abstract Introduction:  Acute kidney injury (AKI) after cardiac surgery is a common and serious postoperative complication and is associated with an increased risk of mortality, morbidity, length of hospital stay,..

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Learning from experience: a qualitative study of surgeons’ perspectives on reporting and dealing with serious adverse events

Abstract Introduction In surgery, serious adverse events have effects on the patient journey, the patient outcome and may constitute a burden to the surgeon involved. This study aims to investigate facilitators..

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Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis

Abstract Extracorporeal support modalities are highly prothrombotic. Anticoagulation is frequently used for patients receiving Continuous Renal Replacement Therapy (CRRT), Molecular Adsorbent Recirculating System (MARS), and Extracorporeal Membrane Oxygenation (ECMO). The..

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Lower Versus Higher Oxygenation Targets for Critically Ill Patients: A Systematic Review

Abstract Supplemental oxygen is a standard therapeutic intervention for critically ill patients such as patients suffering from cardiac arrest, myocardial ischemia, traumatic brain injury, and stroke. However, the optimal oxygenation..

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The AngioVac System in Childhood and Adolescence: A New Venovenous Extracorporeal Membrane Oxygenation-Like Configuration

Abstract Intravascular and intracardiac clots, thrombi, and vegetative material can be safely and effectively treated with the AngioVac System (AngioDynamics, Latham, NY) as an alternative to open surgery. However, this..

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The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass

Abstract Background Extracorporeal life support (ECLS) has extensive applications in managing patients with acute cardiac and pulmonary failure. Two primary modalities of ECLS, cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation..

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High Cell Saver Autotransfusion is Associated With Perioperative Medical Complications in Adult Spinal Deformity Patients

Abstract Study Design.  A retrospective, propensity-matched observational study. Objective.  To assess the impact of cell saver (CS) homologous transfusion on perioperative medical complications in adult patients undergoing spinal deformity surgery...

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Microcirculatory Monitoring in Children with Congenital Heart Disease Before and After Cardiac Surgery

Abstract In this prospective observational study, we investigated whether congenital heart disease (CHD) affects the microcirculation and whether the microcirculation is altered following cardiac surgery with cardiopulmonary bypass (CPB). Thirty-eight..

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Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review

Abstract Angiogenesis is the formation of new blood vessel from existing vessels and is a critical first step in tissue repair following chronic disturbances in healing and degenerative tissues. Chronic..

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A mathematical model for biomechanical behavior of the aortic arch

Abstract The aortic arch plays a significant role in homeostatic mechanisms to retain blood pressure at stable balance in the cardiovascular system. Therefore, the objective is to estimate and identify..

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Complications of Cardiopulmonary Bypass From an Anesthesia Perspective: A Clinical Review

Abstract Cardiopulmonary bypass (CPB) is frequently used for open heart surgery and other procedures that utilize temporary substitution or support of heart and lung function. While it is widely accepted..

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Bleeding patients on extracorporeal membrane oxygenation have reduced platelet aggregation and plasma fibrinogen: a longitudinal observational study

Abstract This study investigated changes in coagulation and associations with occurrence of bleeding and thrombosis during extracorporeal membrane oxygenation (ECMO) therapy. The study included 100 adult ECMO-patients. Standard coagulation parameters,..

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Phosphorylcholine/Heparin Composite Coatings on Artificial Lung Membrane for Enhanced Hemo-compatibility

Abstract As the key component of extracorporeal membrane oxygenation (ECMO), artificial lung membranes have low gas permeability and plasma leakage problems, and the contact between membrane materials and blood can..

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MiECC as Support for Endoscopic Cardiac Surgery

Abstract Beside the tremendous developments in cardiac surgical procedures, the use of cardiopulmonary bypass (CPB) remains the gold standard to perform cardiac surgery but is associated with detrimental effects (e.g...

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Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery

Abstract Objectives Perioperative transfusion thresholds have garnered increasing scrutiny as restrictive strategies have been shown to be noninferior. The study authors used data from a statewide academic collaborative to test..

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Factor XII promotes the thromboinflammatory response in a rat model of veno-arterial extracorporeal membrane oxygenation.

Abstract Objective  (FXII) is a multifunctional  capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in  (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..

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Fibrin and Drainage Insufficiency on Extracorporeal Support: What Came First?

Abstract Drainage insufficiency is a common phenomenon during extracorporeal life support, related to a variable and potentially multiple etiologies. Being associated with impaired extracorporeal blood flow (EBF), so with impaired..

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Year in review: Highlights in ECLS Innovation and Technology, Anno 2022-2023

Abstract Background In the field of extracorporeal life support (ECLS), the rapid influx of novel technologies and innovative techniques presents an ongoing challenge for professionals to stay informed about these..

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Adult Cardiac Surgery-Associated Acute Kidney Injury: Joint Consensus Report

Abstract Objectives  (AKI) is increasingly recognized as a source of poor patient outcomes after cardiac surgery. The purpose of the present report is to provide perioperative teams with expert recommendations..

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Everything About Pulse Oximetry—Part 2: Clinical Applications, Portable/Wearable Pulse Oximeters, Remote Patient Monitoring, and Recent Advances

Abstract Purpose: Pulse oximetry is widely used in healthcare settings for both screening and continuous monitoring. In this article, it was aimed to review some aspects of pulse oximetry including clinical..

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Everything About Pulse Oximetry—Part 1: History, Principles, Advantages, Limitations, Inaccuracies, Cost Analysis, the Level of Knowledge About Pulse Oximeter Among…

Abstract Purpose: Pulse oximetry is a noninvasive medical technique that measures the amount of oxygen in a person’s blood by shining light through their skin. It is widely used in medical..

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Predicting Hemodynamic Changes During Intra-Aortic Balloon Pump Support With a Longitudinal Evaluation

Abstract The use of intra-aortic balloon pump (IABP) has decreased in recent years due to negative outcome studies in cardiogenic shock complicating acute myocardial infarction, despite its favorable adverse-event profile...

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Evaluation of Activated Clotting Times With a Heparin Reversal Protocol Designed to Conserve Protamine During Drug Shortages: A Retrospective, Cohort…

Abstract Objective To retrospectively evaluate a  conservation approach to heparin reversal implemented during times of critical shortages. This approach was aimed at maintaining access to cardiac surgical services. Setting In-patient hospital..

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Mechanisms of Action of the Detrimental Effects of Propofol on Survival

Abstract Due to its favorable pharmacologic features, propofol is the most commonly used hypnotic agent in perioperative and intensive care settings. However, it also has adverse effects like propofol infusion..

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A Narrative Review of Clinical Decision Support Systems for Perioperative Bleeding Management in Cardiac Surgery

Abstract Bleeding complications  undergoing cardiac surgery are common. The clinician must assimilate multiple sources of monitoring information, make rational decisions on the etiology of the bleeding, and then formulate a  strategy.  that acquire..

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How to Solve the Conundrum of Heparin-Induced Thrombocytopenia during Cardiopulmonary Bypass

Abstract Heparin-induced thrombocytopenia (HIT) is a major issue in cardiac surgery requiring cardiopulmonary bypass (CPB). HIT represents a severe adverse drug reaction after heparin administration. It consists of immune-mediated thrombocytopenia..

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Acute stroke in patients undergoing coronary artery bypass grafting surgery in acute coronary syndrome: Predictors and outcomes

Abstract Objectives Coronary artery bypass grafting (CABG) surgery in patients with acute coronary syndrome (ACS) remains a high-risk procedure and is associated with adverse outcomes. The risk factors of acute..

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Comparison of Serial and Parallel Connections of Membrane Lungs against Refractory Hypoxemia in a Mock Circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is an important rescue therapy method for the treatment of severe hypoxic lung injury. In some cases, oxygen saturation and oxygen partial pressure in the..

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Perioperative Iron Deficiency in Patients Scheduled for Major Elective Surgeries: A French Prospective Multicenter Cross-Sectional Study

Abstract BACKGROUND:  The management of perioperative iron deficiency is a component of the concept of patient blood management. The objective of this study was to update French data on the..

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