Yearly Archives: 2023

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Indexed oxygen delivery during pediatric cardiopulmonary bypass is a modifiable risk factor for postoperative acute kidney injury

Abstract Background: Acute kidney injury after pediatric cardiac surgery is a common complication with few established modifiable risk factors. We sought to characterize whether indexed oxygen delivery during cardiopulmonary bypass..

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Custodiol versus blood cardioplegia in pediatric cardiac surgery: a randomized controlled trial

Abstract Background Blood-based cardioplegia is the standard myocardial protection strategy in pediatric cardiac surgery. Custadiol (histidine-tryptophan-ketoglutarate), an alternative, may have some advantages but is potentially less effective at myocardial protection...

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Unveiling the Clinical Benefits of High-Volume Hemodiafiltration: Optimizing the Removal of Medium-Weight Uremic Toxins and Beyond

Abstract Dialysis treatment has improved the survival of patients with kidney failure. However, the hospitalization and mortality rates remain alarmingly high, primarily due to incomplete uremic toxin elimination. High-volume hemodiafiltration..

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Concomitant Use of VA-ECMO and Impella Support for Cardiogenic Shock

Abstract Background: VA-ECMO with concomitant Impella support (ECpella) is an emerging treatment modality for cardiogenic shock (CS). Survival outcomes by CS etiology with ECpella support have not been well-described. Methods: This study..

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The Effect of Visits by Operating Room Nurses Before Cardiac Surgery on Anxiety and Pain Management

Abstract Purpose Further studies are needed in line with the Enhanced Recovery for Cardiac Surgery (ERCS) protocols with a view to reducing anxiety and opioid use in cardiac surgery patients...

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Predictors of Survival Outcomes and Discharge Location following VA-ECMO

Abstract Background: Mortality and complication rates remain high with VA-ECMO. Understanding risk factors for mortality and post-ECMO functional status may aid conversations about prognosis. Methods: ELSO Registry data for adults supported with..

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An emerging complementary strategy to treat acute heart failure (AHF) and cardiogenic shock (CS): the first clinical trial in China…

Abstract Mechanical circulatory support (MCS) is an emerging therapy for acute heart failure (AHF) or cardiogenic shock (CS) patients unresponsive to medicinal treatment. In China, common treatments using short-term MCS..

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Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial

Abstract BACKGROUND: Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) is beneficial for the treatment of profound cardiogenic shock, peripheral VA-ECMO cannulation can increase left ventricular afterload, thus compromising myocardial recovery. We..

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3D-Printed silicone anatomic patient simulator to enhance training on cardiopulmonary bypass

Abstract Background: Simulator training is important for teaching perfusion students fundamental skills associated with CBP before they start working in the clinic. Currently available high-fidelity simulators lack anatomic features that..

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The role of ECMO support in airway procedures

Abstract The role of ECMO support in airway procedures

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Plasma-Free Strategy for Cardiac Surgery with Cardiopulmonary Bypass in Infants < 10 kg: A Retrospective, Propensity-Matched Study

Abstract Background: Infants < 10 kg undergoing cardiac surgery with cardiopulmonary bypass (CPB) may receive either fresh frozen plasma (FFP) or other solutions in the CPB priming volume. The existing..

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Porcine Normothermic Isolated Liver Perfusion

Abstract Porcine models of liver ex situ normothermic machine perfusion (NMP) are increasingly being used in transplant research. Contrary to rodents, porcine livers are anatomically and physiologically close to humans, with similar..

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Advanced hemocompatible polyethersulfone composite artificial lung membrane with efficient CO2/O2 exchange channel constructed by modified carbon nanotubes network

Abstract Artificial lung membranes as the core module of the extracorporeal membrane oxygenation technology (ECMO) execute the function of extracorporeal blood-gas barrier accomplishing CO2/O2 exchange with blood. However, the unsatisfactory hemocompatibility..

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Efficacy and safety of inhaled nitric oxide administered during cardiopulmonary bypass for pediatric cardiac surgery: a systematic review and meta-analysis

Abstract Background and aims:  Cardiopulmonary bypass (CPB) utilized for cardiac surgeries has been associated with significant mortality and adverse outcomes. The benefits of incorporating nitric oxide (NO) into the CPB..

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The Prognostic Value of Johns Hopkins Hospital Nutrition Support Score in Older Patients Undergoing Cardiovascular Surgery

Abstract Objectives Clarify the prognostic value of the Johns Hopkins Hospital Nutrition Support (JHHNS) score on clinical outcomes in older patients undergoing  with  (CPB). Design A retrospective observational study. Setting A teaching..

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Evaluation of the endotracheal tube cuff pressure changes during cardiac operations under cardiopulmonary bypass

Abstract Introduction: Tracheal intubation is used for most operations under general anesthesia. Prolonged hyperinflation of the tube cuff can compromise tracheal mucosal perfusion, and low pressure of the cuff may cause..

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Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study

Abstract Background A multidisciplinary group of stakeholders were used to identify: (1) the core competencies of a training program required to perform in-hospital  initiation (2) additional competencies required to perform pre-hospital  initiation..

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Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections

Abstract Outcomes of pediatric patients who received extracorporeal life support (ECLS) for COVID-19 remain poorly described. The aim of this multi-institutional retrospective observational study was to evaluate these outcomes and..

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Association Between Thrombin–Antithrombin Complex and Acute Kidney Injury After Pediatric Cardiopulmonary Bypass Surgery: A Single-Center Retrospective Observational Study

Abstract Vascular endothelial damage may activate hypercoagulation and contribute to the development of acute kidney injury (AKI). This study aimed to investigate whether early alteration in coagulation was associated with..

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‘Herding cats’: A mixed methods investigation into the educational value of debriefing in operating theatres

Abstract Aim: The aim of the study was to explore the value of debriefing to enhance learning within operating theatres. Methods: A sequential mixed method study was undertaken at a..

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Clinical efficacy of intraoperative Cell Saver autologous blood salvage in emergency surgery for massive hemothorax

Abstract The objective of this study was to investigate the efficacy of intraoperative Cell Saver blood salvage during emergency surgery for massive hemothorax on minimizing perioperative allogeneic red blood cell..

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The impact of using fresh frozen plasma in cardiopulmonary bypass preparation on thromboelastometric parameters and receiving blood products among pediatric…

Abstract Introduction: The aim of this study was to determine the effect of fresh frozen plasma (FFP) for priming of cardiopulmonary bypass (CPB) circuit on rotational thromboelastometry (ROTEM) and transfusion in..

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Performance of the transoesophageal echocardiography probe as an oesophageal temperature monitor in patients undergoing cardiac surgery with cardiopulmonary bypass: a…

Abstract OBJECTIVES Core temperature monitoring is critical during cardiopulmonary bypass (CPB). In this prospective observational study, we investigated the performance of the transoesophageal echocardiography (TOE) probe for core (oesophageal) temperature..

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The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

Abstract The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via mechanical and electrical junctions. Although described in some detail by light microscopy in the 19th century,..

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Coronary artery bypass grafting in active or recent COVID-19 infection: a systematic review

Abstract Introduction Even though there have been few studies on coronary artery bypass grafting (CABG), data on patients with coronavirus disease-2019 (COVID-19) infection show that cardiac surgery has poor outcomes..

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Outcomes in Obese Adult Veno-Venous Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Obesity is associated with an overall increased risk of morbidity and mortality. However, in patients with critical illness, sepsis, and acute respiratory distress syndrome, obesity may be protective, termed..

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ECMO for Premature Neonates- Are we there yet?

Abstract Despite ECMO being a well-accepted and established life-saving support for newborns, prematurity (<34 weeks of gestation) and low birth weight <2.0 kg are still considered relative contraindications due to..

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Comparison of the effects of autologous and non-autologous blood transfusions on the advantages, disadvantages, extubation time and bleeding after coronary…

Abstract Purpose Blood transfusion; is considered an organ transplant. In coronary bypass surgery, large volumes of homologous blood transfusion may be required due to excessive bleeding. The large number of..

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Lower Oxygen Tension and Intracranial Hemorrhage in Veno-venous Extracorporeal Membrane Oxygenation

Abstract Introduction and Methods We examined the relationship between 24-h pre- and post-cannulation arterial oxygen tension (PaO2) and arterial carbon dioxide tension (PaCO2) and subsequent acute brain injury (ABI) in..

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Utilizing retrograde autologous priming for blood conservation in cardiac surgery

Abstract Background The use of crystalloid priming for extracorporeal circuit in adult cardiac surgery causes inevitable haemodilution. The haemodilution can be reduced by using methods such as retrograde autologous priming..

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