Perfusfind S.L.
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Variation in preoperative antithrombotic strategy, severe bleeding, and use of blood products in coronary artery bypass grafting: results from the…

Abstract Aims No data exists on inter-institutional differences in terms of adherence to international guidelines regarding the discontinuation of antithrombotics and rates of severe bleeding in coronary artery bypass grafting..

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Predictors of Postoperative Acute Kidney Injury after Coronary Artery Bypass Graft Surgery

Abstract Objective: The aims of this study were to identify the risk factors associated with acute kidney injury (AKI) after isolated surgical revascularization with cardiopulmonary bypass and to develop a..

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Albumin 5% Versus Crystalloids for Fluid Resuscitation in Children After Cardiac Surgery*

Abstract Objectives:  To determine the clinical benefit of using colloids versus crystalloids for volume resuscitation in children admitted after cardiac surgery. Design:  Retrospective pre-/postintervention cohort study. Setting:  Stollery Children’s Hospital..

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Bleeding, Thrombosis, and Transfusion With Two Heparin Anticoagulation Protocols in Venoarterial ECMO Patients

Abstract Objective To compare the incidence of bleeding and  between adult venoarterial (VA)  (ECMO) patients managed with an  (ACT)-guided heparin  protocol and activated  (aPTT) protocol. Design . Setting Tertiary care, academic medical center...

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Perioperative Characteristics of the Accuracy of Subcutaneous Continuous Glucose Monitoring: Pilot Study in Neurosurgery and Cardiac Surgery

Abstract Background: The aim of this study was to elucidate the characteristics of accuracy of subcutaneous continuous glucose monitoring (SCGM) in the perioperative period for neurosurgical and cardiac surgery patients. Methods: Forty-five..

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Clinical Practice Guidelines What’s Next?

Abstract Clinical practice guidelines are a key component of medicine, as they provide evidence-based recommendations for physicians and other health care professionals about the management of care for patients with..

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Validation of renal-risk models for the prediction of non-renal replacement therapy cardiac surgery-associated acute kidney injury

Abstract Background Cardiac surgery-associated acute kidney injury (AKI) is a serious complication of cardiac surgery, even when renal replacement therapy (RRT) is not required. The existing risk models for cardiac..

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Pediatric extracorporeal membrane oxygenation (ECMO): a guide for radiologists

Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for pediatric patients with respiratory and/or cardiac failure. The ECMO circuit oxygenates and sometimes pumps the blood, effectively replacing lung and/or..

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Feasibility of autologous intraoperative blood collection and retransfusion in small children with complex congenital heart defects undergoing cardiopulmonary bypass

Abstract Introduction Allogeneic blood product transfusion is common in pediatric patients undergoing cardiopulmonary bypass although it is associated with an increased risk for adverse events. Furthermore, numerous donor exposures may..

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The Starling Relationship and Veno-Arterial ECMO: Ventricular Distension Explained

Abstract The use of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) to support patients with acute heart failure has been associated with ventricular distension and pulmonary edema, the mechanism of which..

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Does full sternotomy have more significant impact than the cardiopulmonary bypass time in patients of mitral valve surgery?

Abstract Background Over the past decade, minimally invasive mitral valve surgery (MIMVS) has grown in popularity. Less invasive approaches to mitral valve surgery are increasingly used for improved cosmesis. We..

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Prospective, Randomized Un-Blinded Three Arm Controlled Study in Coronary Artery Revascularization with Minimal Invasive Extracorporeal Circulation Systems (MiECC): Surrogate Parameter…

Abstract Objectives: Minimal extracorporeal circulation techniques and systems (MiECC) may reduce the negative side effects of conventional extracorporeal circulation (ECC). However, it is still unclear as to what this is caused..

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Long‐term outcomes and cost effectiveness of high‐dose dexamethasone for cardiac surgery: a randomised trial

Abstract Summary Prophylactic intra‐operative administration of dexamethasone may improve short‐term clinical outcomes in cardiac surgical patients. The purpose of this study was to evaluate long‐term clinical outcomes and cost effectiveness..

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A narrative review of the technical standards for extracorporeal life support devices (pumps and oxygenators) in Europe

Abstract This review summarizes the European rules to control the market when introducing new products. In particular, it shows all the steps to achieve the European Conformity (CE Mark), a..

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Effects of sodium citrate, citric acid and lactic acid on human blood coagulation

Abstract Introduction: Citric acid infusion in extracorporeal blood may allow concurrent regional anticoagulation and enhancement of extracorporeal CO2 removal. Effects of citric acid on human blood thromboelastography and aggregometry have never..

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Continuous cytokine haemoadsorption incorporated into a venoarterial ECMO circuit for the management of postcardiotomy cardiogenic and septic shock – a…

Abstract Introduction: The acute surgical treatment of infective endocarditis (IE) carries a high risk of postoperative mortality. Most complications are linked to uncontrolled sepsis and inflammatory processes. Cytokine haemoadsorption is..

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Cardiac Surgery–Associated Kidney Injury in Children and Renal Oximetry

Abstract Objectives:  Cardiac surgery–associated acute kidney injury is common in children and associates with negative outcomes. Novel interventions to reduce cardiac surgery–associated acute kidney injury require knowledge of its pathophysiology...

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Pre-operative level of FGF23 predicts severe acute kidney injury after heart surgery in children

Abstract Background Early detection of acute kidney injury (AKI) after cardiac surgery has improved recently with the discovery and validation of novel urinary biomarkers. However, objective tools to predict the..

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Anticoagulation with VADs and ECMO: walking the tightrope

Abstract The evolution of devices for mechanical circulatory support (MCS), including ventricular assist devices (VADs) for patients with heart failure and extracorporeal membrane oxygenation (ECMO) for patients with acute cardiac..

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Favorable late survival after aortic surgery under straight deep hypothermic circulatory arrest

Abstract Background Surgical and cerebral protection strategies in  remain under debate. Perioperative results using deep hypothermic circulatory arrest (DHCA) have been associated with favorable short-term mortality and stroke rates. The present..

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Heparin–protamine balance after neonatal cardiopulmonary bypass surgery

Abstract Essentials   Heparin‐protamine balance (HPB) modulates bleeding after neonatal cardiopulmonary bypass (CPB). HPB was examined in 44 neonates undergoing CPB. Post‐operative bleeding occurred in 36% and heparin rebound in..

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Perioperative Use of Levosimendan Improves Clinical Outcomes in Patients After Cardiac Surgery: A Systematic Review and Meta-Analysis

Abstract Severe postoperative complications can affect cardiac surgery patients. Levosimendan is a novel calcium sensitizer commonly administered after cardiac surgery. However, the patient benefits are controversial. PubMed, Embase, and the..

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Does Ticagrelor Improve Endothelial Function?

Abstract Ticagrelor is a P2Y12 receptor antagonist with proven clinical benefit in patients with acute coronary syndrome. Apart from its principal antiplatelet action, pleiotropic effects have been implicated in the clinical..

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Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia

Abstract Extracorporeal membrane oxygenation (ECMO) is an emerging tool for supporting cardiopulmonary function in patients with cardiorespiratory failure or arrest. The oxygenator of the ECMO circuit requires effective oxygenation and..

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Unique static discharge events on two CentriMag® (2nd Gen) ECMO patients causing console failure

Abstract The use of ECMO for cardiovascular support continues to increase in the United States and around the world. It is not a benign endeavor as serious complications may occur...

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Ultrastructural changes in red blood cells in aortic dissection patients under extracorporeal circulation: Atomic force microscopy study

Abstract Purpose: During extracorporeal circulation in heart surgery, blood is exposed to non-physiological conditions, such as high shear stress, foreign surfaces, turbulence, and hypothermia. These factors cause damage to the..

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Chemical and pharmacological aspects of neutralization of heparins from different animal sources by protamine

Abstract Background Protamine neutralization is an essential step for the safe use and inactivation of the unfractionated heparin (UFH) that is widely employed in surgical and non-surgical procedures involving extracorporeal..

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Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery

Abstract Acute kidney injury (AKI) is a common and serious complication of cardiac surgical procedures that require prolonged (>90 min) cardiopulmonary bypass (CPB) (, ). Although the presence of AKI after..

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Preoperative anemia versus blood transfusion: Which is the culprit for worse outcomes in cardiac surgery?

Abstract Background Reducing blood product utilization after cardiac surgery has become a focus of  as studies have suggested improved outcomes. The relative impact of preoperative anemia versus packed red blood cells..

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