Perfusfind S.L.
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Quality control and maintenance of intraoperative cell salvage instruments

Abstract Objectives Intraoperative cell salvage (ICS) is broadly used in high-risk surgical procedures to facilitate rapid autologous red blood cell transfusion, minimizing the need for allogeneic blood and its associated..

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How Would We Prevent Our Own Acute Kidney Injury After Cardiac Surgery?

Abstract Acute Kidney Injury (AKI) is a common complication after cardiac surgery affecting up to 40% leading to increased morbidity and mortality. To date, there is no specific treatment for..

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Perioperative Normoxia versus Hyperoxia in Neonates with Cyanotic Heart Disease Undergoing Cardiac Surgery: A Randomized Controlled Trial

Abstract BACKGROUND Exposure to supra-physiologic levels of oxygen has been associated with end-organ damage and worse outcomes across multiple populations related to oxidative stress and inflammation. There is limited evidence..

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Perfusionists, Surgeons, and Anesthesiologists: A History of Successful Multidisciplinary Collaboration: What's Next?

Abstract Licensure in medicine originated in London when a small group of physicians led by the scholar Thomas Linacre petitioned King Henry VIII to establish a college of physicians on..

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Outcomes after extracorporeal cardiopulmonary resuscitation in pediatric in-hospital cardiac arrest: does quality of CPR matter?

Abstract Background ECPR patients who receive guideline-compliant CPR will have improved survival to hospital discharge (SHD) compared to patients who do not receive guideline-compliant CPR, regardless of CPR duration. Methods..

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The World's First Hydromagnetic Artificial Heart: A Revolutionary Innovation in Cardiovascular Medicine

  Abstract Heart failure remains a leading cause of morbidity and mortality globally, particularly among individuals with advanced forms of the disease. This study introduces a groundbreaking hydromagnetic artificial heart..

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Personalized ventilation guided by electrical impedance tomography with increased PEEP improves ventilation-perfusion matching in asymmetrical airway closure and contralateral pulmonary…

Abstract We report the case of a 54-year-old man with right-lung pneumonia and contralateral pulmonary embolism (PE) conditioning severe refractory hypoxemia requiring veno-venous extracorporeal membrane oxygenation. Electrical impedance tomography (EIT)..

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Comparison of Hemodynamic Circulation in Pulsatile and Nonpulsatile Extracorporeal Membrane Oxygenation Systems Using an In-Vitro Heart Model

Abstract This study conducts an in-vitro experiment using a mock circulation system that mimics human circulation to assess the veno-arterial extracorporeal membrane oxygenation (ECMO) system. This study aims to compare the hemodynamic..

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Artificial Placenta and Artificial Womb Technologies for Lung and Kidney Failure: A Holistic Perspective

Abstract Preterm birth remains the leading cause of mortality among neonates. Despite improvements in neonatal intensive care over the years, current treatments for lung and kidney failure are highly invasive,..

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Prognostic Role of Pre-Cannulation Lactate in Trauma Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation

Abstract Although venovenous (VV) extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for trauma patients with severe respiratory failure, its mortality rate is 27%, and optimal metabolic markers for its..

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Veno-Arterial Extracorporeal Membrane Oxygenation: A Better Pressor

Introduction Profound hypotension and end-organ hypoperfusion is most often a consequence of inadequate systemic blood flow from primary cardiac failure (cardiogenic shock) or hemorrhage (hemorrhagic shock). However, profound hypotension may..

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Anticoagulant Sulfonate Polyamide/Poly(ether sulfone) Membrane Barrier for Efficient Blood Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) is the most important support for patients with severe cardiopulmonary failure. As the key component, the oxygenation membrane has suffered the risk of blood coagulation..

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Extracorporeal Membrane Oxygenation in Pediatric Patients With Congenital Heart Disease: Surgical Considerations

Abstract The use of extracorporeal membrane oxygenation (ECMO) in the paediatric population has increased over time, with the ability to rescue pulmonary and cardiovascular deterioration. ECMO can be utilised by..

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Multimodal Brain Monitoring in Cardiac Surgery and Postoperative Patient Outcomes

Abstract Objective To describe the occurrence of cerebral desaturation (≥10% decrease or <50% in regional cerebral oxygen saturation [rSO₂]), deep anesthetic states (processed electroencephalography patient state index [PSI] <25), and..

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Impact of Body Mass Index on Stroke in Extracorporeal Cardiopulmonary Resuscitation: Data from the Extracorporeal Life Support Organization Registry

Abstract Objective: We aimed to characterize the impact of body mass index (BMI) on stroke in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR).    Methods: We queried the Extracorporeal Life Support Organization registry..

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Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation

Abstract Background The effect of Friday the 13th and Full Moons on cardiac transplantation is unknown. We investigated the impact of these superstitious events on recipient and donor qualities, complications,..

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Investigation of the impact of antithrombin deficiency on the inflammatory response: Results from a single centre cohort study

Abstract Background Antithrombin signalling may exert an anti-inflammatory effect; therefore we hypothesised that individuals with inherited antithrombin deficiency (ATD) may have an altered inflammatory state. Aims To assess the inflammatory..

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Regulation of Cardiac Function by the Autonomic Nervous System

Abstract The autonomic nervous system is critical for regulating cardiovascular physiology. The neurocardiac axis encompasses multiple levels of control, including the motor circuits of the sympathetic and parasympathetic nervous systems,..

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Kidney replacement therapy during extracorporeal membrane oxygenation: pathophysiology, technical considerations, and outcomes

Abstract The use of extracorporeal membrane oxygenation has been increasing over time, in part due to the COVID-19 pandemic. Whilst lifesaving, complications that must be managed are also associated with..

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Identifying and preliminary validating patient clusters in coronary artery bypass grafting: integrating autonomic function with clinical and demographic data for…

Abstract Aims This study aims to identify distinct clusters of patients undergoing coronary artery bypass grafting (CABG) based on demographic, clinical, and autonomic function characteristics and to validate these clusters...

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Postcardiotomy extracorporeal membrane oxygenation after elective, urgent, and emergency cardiac operations: Insights from the PELS observational study

Abstract Background Outcomes in cardiac surgery are influenced by surgical priority, with higher mortality in emergency cases. Whether this applies to postcardiotomy venoarterial (VA) extracorporeal membrane oxygenation (ECMO) remains unknown...

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The dosage makes the poison – ECMO support considerations in poisoning

Abstract Acute poisoning may lead to life-threatening conditions that require advanced life support, such as extracorporeal membrane oxygenation (ECMO). Data about the use of ECMO in intoxications and overdose are..

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Impact of high-fidelity simulation on the performance of oxygenator change-outs among perfusion students

Abstract Background Simulation is increasingly utilized in the clinical training of healthcare professionals. Many perfusion programs in the United States use simulation to teach students both technical skills and effective..

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Navigating coagulation: Key markers in the first 24 hours of pediatric ECMO

Abstract Background Anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO) presents unique challenges due to developmental hemostasis, coagulation factor production, and response to anticoagulants. This process requires close monitoring to prevent..

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Left ventricular unloading during extracorporeal cardiopulmonary resuscitation: a target trial emulation of the ELSO registry

Abstract Background: Patients who undergo extracorporeal cardiopulmonary resuscitation (ECPR) are at risk of left ventricular distention and complications. There is emerging evidence that concurrent mechanical left ventricular (LV) unloading (e.g...

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Reasons for death in patients receiving ECPR for refractory out-of-hospital cardiac arrest

Abstract Background There are limited data on the causes of death in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). This study aimed to analyse the causes of death among patients who..

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Standby Extracorporeal Membrane Oxygenation Use in Obstetric Patients: A Systematized Review

Abstract EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) is a potentially life-saving intervention often used in critically ill patients with severe respiratory or cardiac failure unresponsive to conventional treatments. As the prevalence of..

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Prone positioning during veno-venous extracorporeal membrane oxygenation: asystematic review and meta-analysis

Abstract Purpose: The evidence supporting the benefit on clinical outcomes of prone positioning during veno-venous extracorporeal membrane oxygenation (V-V ECMO) for acute hypoxemic respiratory failure remains inconclusive. We aimed to..

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Impact of Prehospital Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest on Survival with Good Neurological Function: A Systematic Review and…

Abstract Aim Prehospital extracorporeal cardiopulmonary resuscitation (ECPR) has been proposed to reduce delays in ECPR delivery in refractory out-of-hospital cardiac arrests (OHCA) and improve outcomes. Our aim was to synthesize..

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Candidacy Decision Making for Extracorporeal Cardiopulmonary Resuscitation (ECPR): Lessons from a Single-Center Retrospective Analysis

Abstract Objective Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used to rescue patients in cardiac arrest. However, minimal data guide candidacy decisions, and centers must develop their own initiation criteria, raising..

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