Perfusfind S.L.
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Correlation among decreased regional cerebral oxygen saturation, blood levels of brain injury biomarkers, and cognitive disorder

Abstract Objective This study was performed to investigate the correlation among decreased regional cerebral oxygen saturation (rSO2), blood levels of brain injury biomarkers, and postoperative cognitive disorder (POCD) after cardiac..

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Defining an Intraoperative Hypotension Threshold in Association with Stroke in Cardiac Surgery

Abstract What We Already Know about This Topic Ischemic stroke after cardiac surgery is a devastating complication affecting approximately 2% of patients The relationship between hypotension occurring before, during, and..

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Improving hemolysis levels associated with cardiotomy suction

Abstract Background: The major source of hemolysis during cardiopulmonary bypass (CPB) remains the cardiotomy suction.1 Previous research has shown that the combination of negative pressures and the massive air-blood interface exponentially..

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Addressing the challenges of ECMO simulation

Abstract Introduction/Aim: The patient’s condition and high-risk nature of extracorporeal membrane oxygenation (ECMO) therapy force clinical services to ensure clinicians are properly trained and always ready to deal effectively with..

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The impact of hyperoxia on outcomes after cardiac surgery: a systematic review and narrative synthesis

Abstract Purpose Historically, cardiac surgery patients have often been managed with supraphysiologic intraoperative oxygen levels to protect against the risks of cellular hypoxia inherent in the un-physiologic nature of surgery..

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Cardiopulmonary Bypass in Non-Cardiac Surgery

Background  (CPB) and  membrane oxygenation (ECMO) are used to facilitate  in standard cardiac surgery and emergency intervention, but CPB and ECMO are not used routinely in  involving the  and major vessels. The primary aim..

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A Table Mounted Cardiopulmonary Bypass System for Pediatric Cardiac Surgery

Abstract Systemic inflammatory response and  are prominent factors associated with  and result in increased morbidity and mortality in children. Miniaturized systems have evolved to decrease such effects and restrict use of blood..

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The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction

Abstract Introduction: Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory and immune response. Objective: An in-vitro model of cardiotomy suction was designed to quantify the effects of incrementally increased air-blood..

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Albumin priming improves the efficiency of the Minntech HPH Jr. hemoconcentrator

Abstract The desired use of the HPH Jr. is optimal due to the low priming volume; however, the lower rate of volume removal necessitates utilization of a larger hemofilter. Larger..

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Long venous cannula on the arterial position for VA-ECMO

Abstract Differential hypoxia and the arterial mixing zone are two important factors in managing peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO). With the aim of improving perfusion to the aortic arch..

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A red cell preservation strategy reduces postoperative transfusions in pediatric heart surgery patients

Summary Background Blood transfusion has well‐documented adverse effects. As part of a blood conservation initiative at our center, we began routine use of cell saver for all congenital heart surgery..

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Two cases of “stone heart” with fatal outcome

Abstract The “stone heart” syndrome is a rare but often fatal complication of cardiac surgery associated with hypertrophy of the myocardium. The mechanisms behind the syndrome are not fully understood...

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Bleeding Complications After Use of Novel Oral Anticoagulants in Patients Undergoing Cardiac Surgery

Abstract Background The study was performed to analyze the results of  and bleeding complications after administration of novel  (NOAC). Methods We investigated 81 consecutive patients (median age 74 years, interquartile range [IQR]:..

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Transcatheter Aortic Valve Replacement for Left Ventricular Assist Device–Induced Aortic Insufficiency

SURGICAL AORTIC VALVE replacement historically has been the standard of care for patients with severe, symptomatic aortic stenosis. However, up to one-third of patients with symptomatic aortic stenosis are not..

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Late-onset right ventricular dysfunction after mechanical support by a continuous-flow left ventricular assist device

Abstract Background Right heart failure (RHF) is a serious post-operative complication of left ventricular assist device (LVAD) implantation, with significant morbidity and mortality. Many clinical, hemodynamic and laboratory variables have..

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Surgical Technique Influences HeartMate II Left Ventricular Assist Device Thrombosis

Background  of the HeartMate II (HM2 [Thoratec Corporation, Pleasanton, CA]) is a potentially devastating complication. While attention has been focused on  strategies to prevent this complication, the impact of surgical technique..

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Algorithm for the diagnosis and management of suspected pump thrombus

Abstract Pump thrombosis is a dreaded complication of long-term implantable ventricular assist devices. No guidance exists regarding the diagnosis and management of this entity despite its significant morbidity. After considerable..

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Treatment of device thrombus in the HeartWare HVAD: Success and outcomes depend significantly on the initial treatment strategy

Background Pump thrombosis is a major adverse event in patients supported with a left ventricular assist device (LVAD). Treatment approaches include device exchange, lytic therapy, or augmentation of anticoagulation or..

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Continuous-Flow Left Ventricular Assist Device Implantation in Patients With a Small Left Ventricle

Background Having a preoperative small  (LV) has been associated with higher complication and mortality rates after  (LVAD) implantation; however, the outcomes after continuous-flow LVAD implantation have not been well studied. This is..

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Clinical and In Vitro Evidence That Subclinical Hemolysis Contributes to LVAD Thrombosis

Background Recent data suggest that  contributes to  (LVAD) , but the mechanism is unknown. In a clinical study, we measured plasma free hemoglobin (pfHgb) and the incidence of LVAD thrombosis. In an in..

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Hetastarch Should be Avoided for Volume Expansion in Cardiac Surgery Patients

Abstract Blood conservation measures to reduce perioperative blood loss during cardiac surgery have been a subject of focus in recent years. This is due in part to the high cost..

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Comparison of Ringer’s Lactate and Plasmalyte-A as Cardiopulmonary Bypass Prime for Bypass Associated Acidosis in Valve Replacement Surgeries

Abstract Introduction A wide range of acid base fluctuations are seen during Cardiopulmonary bypass (CPB) and the development of metabolic acidosis is well recognized. We conducted a study tocompare the..

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Writing’s on the Wall: Improving the Who Surgical Safety Checklist

Abstract Background and problem  The WHO Surgical Safety Checklist has been shown to improve patient safety as well as improving teamwork and communication in theatres. In 2009, it was made..

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The Role of Frailty in Failure to Rescue After Cardiovascular Surgery

Abstract Background Failure to rescue (FTR) is gaining popularity as a quality metric. The relationship between patient frailty and FTR after cardiovascular surgery has not been fully explored. This study..

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Methodologic Considerations on Four Cardiovascular Interventions Trials With Contradictory Results

Abstract Background Contradictory findings from randomized trials addressing similar research questions are not uncommon in medicine. Although differing results may reflect true differences in the treatment effects or in the..

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Low Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO): A Randomized Controlled Trial

Abstract Background Postoperative pulmonary complications are common after cardiac surgery and have been related to lung collapse during cardiopulmonary bypass (CPB). No consensus exists regarding the effects of maintaining mechanical..

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Variability in Anesthesia Models of Care in Cardiac Surgery

Abstract The operating room in a cardiothoracic surgical case is a complex environment, with multiple handoffs often required by staffing changes, and can be variable from program to program. This..

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Retrograde Autologous Priming in Cardiac Surgery: Results From a Systematic Review and Meta-analysis

Abstract Background:  Retrograde autologous priming (RAP) before cardiopulmonary bypass (CPB) may minimize allogeneic red cell transfusion. We conducted a systematic review of the literature to examine the impact of RAP..

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Comparative Pharmacological Profiles of Various Bovine, Ovine, and Porcine Heparins

Abstract Unfractionated heparin is the first anticoagulant drug and has been successfully used clinically for over 80 years. Heparin and its analogues are used during surgery and dialysis and are..

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