Tags Archives: plasma

Perfusfind S.L.

Abstract OBJECTIVES:  In patients with acute hypoxemic respiratory failure (AHRF), the use of lower tidal volume ventilation facilitated by veno-venous extracorporeal CO2 removal (vv-ECCO2R) does not improve clinical outcomes. The primary..

Perfusfind S.L.

Abstract Thrombin generation (TG) is reduced after cardiac surgery using cardiopulmonary bypass (CPB), contributing to coagulopathy and bleeding. Plasma transfusion or four-factor prothrombin complex concentrate (PCC) are commonly used to..

Perfusfind S.L.

Abstract Background and Objectives A plasma transfusion dose should be weight-based (10–20 mL/kg), which equates to three to four units in an average-sized adult; therefore, the transfusion of single units under..

Perfusfind S.L.

Abstract Introduction The study objective was to investigate whether a Ringer’s acetate based priming solution with addition of Mannitol and sodium concentrate increases the risk of cardiac surgery associated kidney..

Perfusfind S.L.

Abstract Background Patients with valvular heart disease require  and cardiac arrest. Here, we test the hypothesis that exosomal hemoglobin formed during  mediates acute cardiac injury in humans and in an animal model..

Perfusfind S.L.

Abstract Background Intraoperative hypofibrinogenemia is a major factor associated with increased postoperative blood loss in adult cardiac surgery. However, previous pediatric studies on this topic did not sufficiently adjust for..

Perfusfind S.L.

Abstract Objective This study aimed to investigate the blood protective effect of autologous platelet-rich plasma in aortic root reconstruction under longtime cardiopulmonary bypass. Method Patients who underwent aortic root reconstruction..

Perfusfind S.L.

Abstract Background Cardiac transplants increasingly occur following placement of ventricular assist devices (VADs). A strong association exists between human leukocyte antigen (HLA) sensitization and VAD placement; however, desensitization protocols that..

Perfusfind S.L.

Abstract Importance  Post–cardiopulmonary bypass (CPB) coagulopathy and bleeding are among the most common reasons for blood product transfusion in surgical practices. Current retrospective data suggest lower transfusion rates and blood loss..

Perfusfind S.L.

Abstract Background: Cardiac surgery with cardiopulmonary bypass (CPB) is commonly associated with acute kidney injury, and microvascular endothelial inflammation is a potential underlying mechanism. We hypothesized that pro-inflammatory components of..

Perfusfind S.L.

Abstract Objectives Our objectives were to determine the separation characteristics and blood product quality of a gravity-driven microfiltration blood separation system (HemoClear, The Netherlands). Background A range of centrifugal blood..

Perfusfind S.L.

Abstract Purpose To develop evidence-based clinical practice recommendations regarding transfusion practices and transfusion in bleeding critically ill adults. Methods A taskforce involving 15 international experts and 2 methodologists used the..

Perfusfind S.L.

Abstract   Background: Ceftaroline fosamil, a 5th generation cephalosporin antibiotic with activity against MRSA, is currently approved for the treatment of pneumonia and complicated skin and soft tissue infections. However,..

Perfusfind S.L.

Abstract Objectives:  To describe blood component usage in transfused children with congenital heart disease undergoing cardiopulmonary bypass surgery across perioperative settings and diagnostic categories. Design:  Datasets from U.S. hospitals participating..

Perfusfind S.L.

Minh Tran, CCP and Joe Basha, CCP discuss the use of passive antibody therapy, also referred to as convalescent plasma.  An old therapy making a resurgence in the treatment of..

Perfusfind S.L.

Abstract Background Better understanding of blood usage rates could identify trends in transfusion practices over time and inform more efficient management. Methods Inpatient admissions from the Healthcare Cost and Utilization..

Perfusfind S.L.

Abstract Objective As with any biomarker, interpretation of changes of  concentration must consider its variability in a specific clinical setting. The aim of this study was to calculate the reference change..

Perfusfind S.L.

Summary There is equipoise regarding the use of prothrombin complex concentrate vs. fresh frozen plasma in bleeding patients undergoing cardiac surgery. We performed a pilot randomised controlled trial to determine..