Etiquetas Archivo: pharmacodynamics

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A Narrative Review of the Impact of Extracorporeal Membrane Oxygenation on the Pharmacokinetics and Pharmacodynamics of Critical Care Therapies

Abstract Objective: Extracorporeal membrane oxygenation (ECMO) utilization is increasing on a global scale, and despite technological advances, minimal standardized approaches to pharmacotherapeutic management exist. This objective was to create a..

Lee mas
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Medicating patients during extracorporeal membrane oxygenation: the evidence is building

Abstract Extracorporeal membrane oxygenation (ECMO), which can support gas exchange or hemodynamics in patients with severe respiratory or cardiac failure, has demonstrated considerable evolution over the last decade [], with..

Lee mas
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Propofol pharmacokinetics and pharmacodynamics—a perspective in minimally invasive extracorporeal circulation

Abstract There is limited evidence as to the pharmacokinetic changes expected in adults with extracorporeal technologies. Drugs may be taken up by various components of the cardiopulmonary bypass circuit itself...

Lee mas
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Propofol pharmacokinetics and pharmacodynamics—a perspective in minimally invasive extracorporeal circulation

Abstract There is limited evidence as to the pharmacokinetic changes expected in adults with extracorporeal technologies. Drugs may be taken up by various components of the cardiopulmonary bypass circuit itself...

Lee mas
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Population Pharmacokinetics and Pharmacodynamic Target Attainment of Meropenem in Critically Ill Young Children

Abstract OBJECTIVE This study aims to describe the population pharmacokinetics and pharmacodynamic target attainment of meropenem in critically ill children. METHODS The study involved a retrospective medical record review from..

Lee mas
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Citrate pathophysiology and metabolism

Abstract By chelating ionized  allows  circuit  without a bleeding risk for the patient. Citrate anticoagulation is also associated with a reduced activation of  and platelets. Citrate clearance by  (Krebs cycle) is not modified by renal..

Lee mas
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Pharmacokinetics of cefazolin delivery via the cardiopulmonary bypass circuit priming solution in infants and children

Abstract Objectives Our aim was to describe the pharmacokinetics of cefazolin in paediatric patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) who received cefazolin for peri-operative surgical prophylaxis in addition..

Lee mas
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Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections

Abstract This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with..

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