Tags Archives: Oxygen delivery

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Association of Low Oxygen Delivery on Cardiopulmonary Bypass and Increased Long-Term Mortality

Abstract Background Although delivering less oxygen is associated with acute kidney injury, little is known about its association with long-term mortality and how the association may be modified by transfusion...

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Patient-Specific Susceptibility to the Nadir Oxygen Delivery on Cardiopulmonary Bypass

Abstract Objectives Maintaining a nadir oxygen delivery ≥ 280 mL/min/m2 during cardiopulmonary bypass is a pillar of the goal-directed perfusion strategy in cardiac surgery. However, there are patients who develop a..

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Patient-Specific Susceptibility to the Nadir Oxygen Delivery on Cardiopulmonary Bypass

Abstract Objectives Maintaining a nadir oxygen delivery ≥ 280 mL/min/m2 during cardiopulmonary bypass is a pillar of the goal-directed perfusion strategy in cardiac surgery. However, there are patients who develop a..

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Successful use of pulsatile flow and goal directed perfusion in a high-risk patient

Abstract The development of multi-organ failure resulting from cardiopulmonary bypass (CPB) is acknowledged as a significant contributor to increased morbidity and mortality rates during the postoperative period. This report discusses..

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Monitoring Oxygen Delivery During Cardiopulmonary Bypass: A Preliminary Multinational Practice Survey

Abstract Objectives Oxygen delivery (DO2) is a pivotal factor in maintaining adequate tissue protection during cardiopulmonary bypass (CPB). Despite its clinical significance, there is currently no global consensus regarding standardized..

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Delivery of oxygen during cardiopulmonary bypass and associated clinical outcomes among adult cardiac surgery patients: A systematic review

Abstract Purpose Oxygen delivery (DO2) during cardiopulmonary bypass (CPB) is critical in preventing postoperative complications in adult cardiac surgery. This systematic review aimed to assess the relationship between intraoperative DO2 during..

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Time-dose response of oxygen delivery during cardiopulmonary bypass in mitral valve surgery: does surgical approach matter?

Abstract Introduction Increased time-dose-response (TDR) of suboptimal oxygen delivery (DO2) during cardiopulmonary bypass (CPB) has been associated with increased postoperative complications. The impact of surgical approach - minimally invasive vs...

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A Temperature-Adjusted Algorithm for Predicting Critical Indexed Oxygen Delivery (DO₂i) During Cardiopulmonary Bypass

Abstract Introduction: Indexed oxygen delivery (DO₂i) is a critical parameter in cardiopulmonary bypass (CPB) management. Traditional goal-directed perfusion (GDP) protocols use fixed DO₂i thresholds, typically derived from normothermic conditions. However,..

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Impact of gender differences on optimal oxygen delivery thresholds to prevent acute kidney injury in cardiac surgeries with cardiopulmonary bypass

Abstract Background The nadir oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) is reportedly associated with acute kidney injury (AKI) in patients undergoing cardiac surgery. However, there are few reports..

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Oxygen delivery and carbon dioxide removal on venovenous extracorporeal membrane oxygenation

Abstract Purpose of review  Venovenous extracorporeal membrane oxygenation (VV-ECMO) provides gas exchange for patients with advanced respiratory failure who cannot maintain adequate oxygenation or carbon dioxide (CO2) clearance through conventional..

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Trial of Oxygen Delivery on Cardiopulmonary Bypass and Major Clinical Outcomes

Abstract Background Low oxygen delivery (DO2) on cardiopulmonary bypass has been associated with acute kidney injury. We sought to determine the association of intraoperative DO2, postoperative length of stay, and..

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Oxygen Delivery During Cardiopulmonary Bypass in Pediatric Patients With Congenital Heart Disease: Association With Postoperative Acute Kidney Injury

Abstract Objective This study was designed to investigate the distribution of nadir oxygen delivery (DO2), mean DO2, and area under ideal DO2 (AUiDO2) among categorized age groups of pediatric patients and..

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The Association of Oxygen Delivery and Transfusion on Cardiopulmonary Bypass with Acute Kidney Injury

Abstract Objectives To estimate whether the association of transfusion and acute kidney injury (AKI) has a threshold of oxygen delivery below which transfusion is beneficial but above which it is..

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Feasibility of continuous non-invasive delivery of oxygen monitoring in cardiac surgical patients: a proof-of-concept preliminary study

Abstract Purpose Oxygen delivery (DO2) and its monitoring are highlighted to aid postoperative goal directed therapy (GDT) to improve perioperative outcomes such as acute kidney injury (AKI) after high-risk cardiac..

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Effect of oxygen delivery during cardiopulmonary bypass on postoperative neurological outcomes in patients undergoing cardiac surgery: A scoping review of…

Abstract Background Reduced oxygen delivery (DO2) during cardiopulmonary bypass (CPB) was proposed as a risk factor for the development of postoperative neurological complications (PONCs), including cerebrovascular accidents (CVA), delirium, and..

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Assessment of a goal-directed perfusion strategy through an oxygen delivery audit

Abstract Introduction Evidence supports the role of oxygen delivery (DO2) in ameliorating acute kidney injury (AKI). While instrumentation for continuous DO2 measurement exists, a simplified method has been reported for targeting..

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Establishment of a national quality improvement process on oxygen delivery index during cardiopulmonary bypass

Abstract Targeted oxygen delivery during cardiopulmonary bypass (CPB) has received significant attention due to its influence on patient outcomes, especially in mitigating acute kidney injury. While it has gained popularity..

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Oxygen Delivery Thresholds During Cardiopulmonary Bypass and Risk for Acute Kidney Injury

Abstract Background Postoperative acute kidney injury (AKI) in cardiac surgery patients is multifactorial and associated with low oxygen delivery (DO2) during cardiopulmonary bypass. Methods Cardiac surgical patients undergoing full cardiopulmonary..

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Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis

Abstract Background Rapid fluid administration may decrease hemoglobin concentration (Hb) by a diluting effect, which could limit the increase in oxygen delivery (DO2) expected with a positive response to fluid..

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Risk factors for postoperative delirium on oxygen delivery-guided perfusion

Abstract Background Studies have demonstrated the efficacy of oxygen delivery-guided perfusion (ODGP) in preventing postoperative acute kidney injury, but the benefit of ODGP for delirium has not been confirmed. We..

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A microfluidic device for real-time on-demand intravenous oxygen delivery

Abstract Oxygen is picked up in the lungs, carried by the blood, and delivered to tissues where it serves as the terminal electron acceptor during oxidative phosphorylation. During health, oxygen..

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Pathophysiology, mechanisms, and managements of tissue hypoxia

Abstract Oxygen is needed to generate aerobic adenosine triphosphate and energy that is required to support vital cellular functions. Oxygen delivery (DO2) to the tissues is determined by convective and..

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Oxygen Delivery in Pediatric Cardiac Surgery and its Association with Acute Kidney Injury using Machine Learning

Abstract Objective Acute kidney injury (AKI) following pediatric cardiac surgery with cardiopulmonary bypass is a frequently reported complication. This study aims to determine the critical oxygen delivery (DO2i) threshold associated..

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Non-invasive and invasive measurement of skeletal muscular oxygenation during isolated limb perfusion

Abstract Background Isolated limb perfusion (ILP) is a regional surgical treatment for localized metastatic disease. High doses of chemotherapeutic agents are administered within an extracorporeal circulated isolated extremity, treating the..

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To RAP or Not to RAP: A Retrospective Comparison of the Effects of Retrograde Autologous Priming

Abstract Retrograde autologous priming (RAP) is a process used to reduce hemodilution associated with the initiation of cardiopulmonary bypass (CPB). Previous studies have reported potential benefits to RAP; however, many..

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The physiology of extracorporeal membrane oxygenation: The Fick principle

Abstract Extracorporeal membrane oxygenation (ECMO) can be delivered in veno-arterial (VA) and veno-venous (VV) configurations based on the cannulation strategy. VA and VV ECMO are delivered primarily for haemodynamic and..

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Adrenaline improves regional cerebral blood flow, cerebral oxygenation and cerebral metabolism during CPR in a porcine cardiac arrest model using…

Abstract Background The effects of adrenaline on cerebral blood vessels during cardiopulmonary resuscitation (CPR) are not well understood. We developed an extracorporeal CPR model that maintains constant low systemic blood..

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Associations between oxygen delivery and cardiac index with hyperlactatemia during cardiopulmonary bypass

Abstract Objective Metabolism management plays an essential role during cardiopulmonary bypass (CPB). There are different metabolic management devices integrated to heart–lung machines; the most commonly used and accepted metabolic target..

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