Abstract BACKGROUND Exposure to supra-physiologic levels of oxygen has been associated with end-organ damage and worse outcomes across multiple populations related to oxidative stress and inflammation. There is limited evidence..
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Introduction Cardiopulmonary bypass (CPB) is a cornerstone of modern cardiac surgery, facilitating a bloodless and motionless field for surgeons. Traditionally, hyperoxia—elevated levels of arterial oxygen tension (PaO₂)—has been employed during..
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Abstract Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic..
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Abstract Purpose Historically, cardiac surgery patients have often been managed with supraphysiologic intraoperative oxygen levels to protect against the risks of cellular hypoxia inherent in the un-physiologic nature of surgery..
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Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery. Studies have identified potentially injurious roles for cardiopulmonary bypass (CPB) and subsequent reperfusion injury. Cognitive dysfunction has..
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