Abstract The human heart has one of highest metabolic requirements in the body: even in a resting physiologic state it must work to circulate approximately 5 L/min to 8 L/min..
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Abstract Oxygen is crucial for mitochondrial energy production in neurons and is efficiently stored and transported within the hydrophobic core of phospholipid bilayers. Using a diffusive model derived from molecular..
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Abstract Common for major surgery, multitrauma, sepsis, and critical illness, is a whole-body inflammation. Tissue injury is able to trigger a generalized inflammatory reaction. Cell death causes release of endogenous..
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Abstract Background Reliable biomarkers for organ quality assessment during normothermic machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by oxidative phosphorylation plays a crucial role in the bioenergetic homeostasis..
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Increased Cerebral Mitochondrial Dysfunction and Reactive Oxygen Species with Cardiopulmonary Bypass
Abstract Objectives Neurodevelopmental injury after cardiac surgery using cardiopulmonary bypass (CPB) for congenital heart defects is common, but the mechanism behind this injury is unclear. This study examines the impact..
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