Tags Archives: hemolysis

Perfusfind S.L.

Abstract Ex vivo hemocompatibility testing is a vital element of preclinical assessment for blood-contacting medical devices. Current approaches are resource intensive; thus, we investigated the feasibility of accelerating hemocompatibility testing by standardizing..

Perfusfind S.L.

Abstract Extracorporeal membrane oxygenation is a life-saving support therapy in the case of cardiopulmonary refractory failure. Its use is associated to complications due to the presence of artificial surfaces and..

Perfusfind S.L.

Abstract Extracorporeal circulation (ECC) procedures, such as cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO), take over the function of one or more organs, providing clinicians time to treat underlying pathophysiological..

Perfusfind S.L.

Abstract Hemolysis usually happens instantly when red blood cells (RBCs) rupture under a high shear stress. However, it is also found to happen gradually in the extracorporeal membrane oxygenation (ECMO)..

Perfusfind S.L.

Abstract The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure..

Perfusfind S.L.

Abstract Objective: To describe factors associated with hemolysis during pediatric extracorporeal membrane oxygenation (ECMO), and the relationships between hemolysis, complications and mortality. Design: Secondary analysis of data collected prospectively by..

Perfusfind S.L.

Abstract In vitro testing of hemolysis is essential for the validation and development of ventricular assist devices. However, as many factors influence hemolysis, such tests’ inter- and intralaboratory reproducibility is poor...

Perfusfind S.L.

Abstract OBJECTIVES:  To determine potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and examine whether supraphysiologic levels of oxygen and cardiopulmonary bypass duration are associated with hemolysis. DESIGN: ..

Perfusfind S.L.

Abstract Introduction Extracorporeal membrane oxygenation (ECMO)–associated hemolysis still represents a serious complication. The present study aimed to investigate those predictive factors, such as flow rates, the use of anticoagulants, and..

Perfusfind S.L.

Abstract The Impella CP (Abiomed Inc., Danvers, MA) is widely used in cardiac catheterization laboratories for patients presenting with cardiogenic shock, but it is also known to cause significant hemolysis. The risk..

Perfusfind S.L.

Abstract Extracorporeal circulation (ECC) procedures, such as cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO), take over the function of one or more organs, providing clinicians time to treat underlying..

Perfusfind S.L.

Abstract Purpose Patients with  (ECLS) are at risk for hemolysis-related complications. Therefore, monitoring of free hemoglobin (fHb) levels is indicated. Conventional methods for fHb are laborious and not always available. Here..

Perfusfind S.L.

Abstract Background Elevated plasma free hemoglobin is associated with multi-organ injury. In this context, minimally invasive extracorporeal technologies represent a way to reduce this complication following cardiac surgery. Methods We..

Perfusfind S.L.

Abstract Blood pumps have been increasingly used in mechanically assisted circulation for ventricular assistance and extracorporeal membrane oxygenation support or during cardiopulmonary bypass for cardiac surgery. However, there have always..

Perfusfind S.L.

Abstract Objective The objective was to determine the optimal cell saver device settings (infusion rate and wash rate) at which hematocrit is preserved and potassium and lactate are removed from..

Perfusfind S.L.

Abstract Highlights • Hemolysis due to CPB leads to an increase of serum free Hemoglobin(fHb) level. • Increase of serum fHb level had an independent association with postoperative AKI. •..

Perfusfind S.L.

Abstract Giani et al. found low levels of carboxyhemoglobin (COHb) in a cohort of patients supported on veno-venous extracorporeal membrane oxygenation (VV ECMO) at their center. It is noteworthy that even on..

Perfusfind S.L.

Abstract The American Society for Testing and Materials (ASTM) F1841 standard for the assessment of hemolysis in blood pumps recommends using phosphate-buffered saline (PBS) for hemodilution to standardize hematocrit (HCT)...

Perfusfind S.L.

Abstract Supraphysiologic high shear stresses created in calcific aortic stenosis (AS) are known to cause hemostatic abnormalities, however, the relationship between the complex blood flows over the severity of AS..

Perfusfind S.L.

Abstract Objective: The aim was to evaluate the performance of a newly developed magnetically suspended centrifugal pump head intended for use as a ventricular assistance device with a newly developed..

Perfusfind S.L.

Abstract Extracorporeal membrane oxygenation (ECMO) can be lifesaving but suffers from high rates of bleeding and repeated transfusions. Current monitoring of blood cell damage during ECMO is limited to platelet..

Perfusfind S.L.

Abstract Hemolysis is a common complication of extracorporeal membrane oxygenation (ECMO) support and is associated with increased mortality. Frequent monitoring of markers of hemolysis is performed at ECMO centers. We..

Perfusfind S.L.

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

Perfusfind S.L.

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

Perfusfind S.L.

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

Perfusfind S.L.

Abstract In a randomized clinical trial in China of 244 adults undergoing elective, multiple valve replacement surgery, Lei and colleagues administered 80 parts per million nitric oxide (NO) gas during..

Perfusfind S.L.

Abstract Acute kidney injury (AKI) is a common and serious complication of cardiac surgical procedures that require prolonged (>90 min) cardiopulmonary bypass (CPB) (, ). Although the presence of AKI after..

Perfusfind S.L.

Abstract Background: The major source of hemolysis during cardiopulmonary bypass (CPB) remains the cardiotomy suction.1 Previous research has shown that the combination of negative pressures and the massive air-blood interface exponentially..

Perfusfind S.L.

Background Recent data suggest that  contributes to  (LVAD) , but the mechanism is unknown. In a clinical study, we measured plasma free hemoglobin (pfHgb) and the incidence of LVAD thrombosis. In an in..

Perfusfind S.L.

Abstract Recent advances in ECLS technology have led to the adoption of centrifugal pumps for the majority of patients worldwide. Despite several advantages of centrifugal pumps, they remain controversial because..