Tags Archives: haemostasis

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From Pandemic to Practice: How COVID-19 Has Reshaped Haemostasis in Cardiac Surgery: A Narrative Review

Abstract The utilisation of cardiopulmonary bypass (CPB) during cardiac surgery is often associated with complex haemostatic perturbations, frequently manifesting as a paradoxical risk of both bleeding and thrombosis. This is..

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Shear-induced dysregulation of haemostasis during extracorporeal membrane oxygenation: From cells to circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is increasingly being utilized in critical care globally to allow for adequate oxygenation in patients with cardiac and/or respiratory failure. Unfortunately, haemostatic complications – both..

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Biomaterials as Haemostatic Agents in Cardiovascular Surgery: Review of Current Situation and Future Trends

Abstract Intraoperative haemostasis is of paramount importance in the practice of cardiovascular surgery. Over the past 70 years, topical haemostatic methods have advanced significantly and today we deal with various..

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Haemostasis in Cardiac Surgery

Abstract The following sections are included: HISTORICAL NOTE DYNAMICS OF COAGULATION, FIBRINOLYSIS, AND COMPLEMENT ACTIVATION CARDIOPULMONARY BYPASS (CPB) Role of Oxygenators in Haemostasis   ANTI-COAGULATION DURING CARDIOPULMONARY BYPASS Heparin Protamine..

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Novel autologous, high concentrated fibrin as advanced hemostatic agent for coronary surgery

Abstract Background Variability in transfusion outcomes and excessive postoperative bleeding represents a significant problem in cardiac surgery. The effort to reduce bleeding complications and transfusion outcomes is desirable. Our study..

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Hypercoagulopathy, acquired coagulation disorders and anticoagulation before, during and after extracorporeal membrane oxygenation in COVID-19: a case series.

Abstract Background: Thromboembolism and bleeding contribute to Coronavirus disease 2019 (COVID-19)’s morbidity and mortality and are also frequent complications of venovenous extracorporeal membrane oxygenation (vvECMO). As the interaction of the..

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Changes in thrombin generation in children after cardiac surgery and ex-vivo response to blood products and haemostatic agents

Abstract Impaired haemostasis has been reported in children with congenital heart disease undergoing cardiopulmonary bypass. As thrombin generation encompasses all phases of the coagulation process, this analysis might provide the best assessment..

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Reduced re-exploration and blood product transfusion after the introduction of the Papworth haemostasis checklist

Abstract OBJECTIVES Between 2% and 8% of patients return to the theatre for mediastinal bleeding following cardiac surgery. In the majority of patients, a surgical source of bleeding is identified...

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The effect of protamine dosing variation on bleeding and transfusion after heparinisation for cardiopulmonary bypass

Abstract Introduction: Accurate dosing of protamine reversal following on-pump cardiac surgical procedures is challenging, with both excessive and inadequate administration recognised to increase bleeding risk. We aimed to examine the..

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