Abstract During extracorporeal membrane oxygenation (ECMO) blood is exposed to artificial surfaces, resulting in contact activation of the intrinsic coagulation pathway initiated by coagulation factor XII (FXII). Little is known..
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Abstract Background (FXII) is a multifunctional capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..
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Abstract Objective (FXII) is a multifunctional capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..
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Abstract Previous studies suggested that contact pathway factors drive thrombosis in mechanical circulation. We used a rabbit model of veno-arterial extracorporeal circulation (VA-ECMO) to evaluate the role of factors XI..
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