Tags Archives: ecmo

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Anticoagulation strategies in COVID-19 infected patients receiving ECMO support

Abstract Background: Hospitalized COVID-19 patients with hypoxemic respiratory failure may deteriorate despite invasive mechanical ventilation and thus require extracorporeal membrane oxygenation (ECMO) support. Unfractionated heparin (UFH) is the antithrombotic of..

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Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial

Abstract BACKGROUND: Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) is beneficial for the treatment of profound cardiogenic shock, peripheral VA-ECMO cannulation can increase left ventricular afterload, thus compromising myocardial recovery. We..

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The role of ECMO support in airway procedures

Abstract The role of ECMO support in airway procedures

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Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections

Abstract Outcomes of pediatric patients who received extracorporeal life support (ECLS) for COVID-19 remain poorly described. The aim of this multi-institutional retrospective observational study was to evaluate these outcomes and..

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ECMO for Premature Neonates- Are we there yet?

Abstract Despite ECMO being a well-accepted and established life-saving support for newborns, prematurity (<34 weeks of gestation) and low birth weight <2.0 kg are still considered relative contraindications due to..

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Lower Oxygen Tension and Intracranial Hemorrhage in Veno-venous Extracorporeal Membrane Oxygenation

Abstract Introduction and Methods We examined the relationship between 24-h pre- and post-cannulation arterial oxygen tension (PaO2) and arterial carbon dioxide tension (PaCO2) and subsequent acute brain injury (ABI) in..

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Challenges of Nutrition Support in Pediatric Patients Requiring Extracorporeal Membrane Oxygenation

Abstract Nutrition support in critically ill infants and children remains an integral part of providing optimal care for these patients. The pediatric patient requiring extracorporeal membrane oxygenation therapy faces specific..

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Extracorporeal Membrane Oxygenation Physiological Factors Influence Pulse Oximetry and Arterial Oxygen Saturation Discrepancies

Abstract Background  strategy, vasopressors, and hemolysis are important physiological factors that influence  in  (ECMO). We hypothesized these factors influence the discrepancy between  measured by  (Spo2) and  (Sao2)  on ECMO. Methods We retrospectively analyzed adults (aged ≥18..

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Multicenter Assessment of a Novel ECMO Cannulation Simulator Using a Standardized Procedural Checklist

Abstract Background: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an emergency procedure performed across various specialties. These conditions present barriers to education and assessment of competency. Checklists and simulation may be..

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Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation

Abstract Background  (FXII) is a multifunctional  capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in  (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..

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Commercial and novel anticoagulant ECMO coatings: a review

Abstract Extracorporeal membrane oxygenation (ECMO) is an invasive and last-resort treatment for circulatory and respiratory failure. Prolonged ECMO support can disrupt the coagulation and anticoagulation systems in a patient, leading..

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The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass

Abstract Background Extracorporeal life support (ECLS) has extensive applications in managing patients with acute cardiac and pulmonary failure. Two primary modalities of ECLS, cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation..

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Bleeding patients on extracorporeal membrane oxygenation have reduced platelet aggregation and plasma fibrinogen: a longitudinal observational study

Abstract This study investigated changes in coagulation and associations with occurrence of bleeding and thrombosis during extracorporeal membrane oxygenation (ECMO) therapy. The study included 100 adult ECMO-patients. Standard coagulation parameters,..

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Phosphorylcholine/Heparin Composite Coatings on Artificial Lung Membrane for Enhanced Hemo-compatibility

Abstract As the key component of extracorporeal membrane oxygenation (ECMO), artificial lung membranes have low gas permeability and plasma leakage problems, and the contact between membrane materials and blood can..

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Comparison of Serial and Parallel Connections of Membrane Lungs against Refractory Hypoxemia in a Mock Circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is an important rescue therapy method for the treatment of severe hypoxic lung injury. In some cases, oxygen saturation and oxygen partial pressure in the..

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Standardized approach for extubation during extracorporeal membrane oxygenation in severe acute respiratory distress syndrome: a prospective observational study

Abstract Background Extubation during extracorporeal oxygenation (ECMO) in severe acute respiratory distress syndrome(ARDS) has not been well studied. Despite the potential benefits of this strategy, weaning from ECMO before libera‑tion..

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Groundbreaking NIH Study Reveals: ECMO More Effective for Obese Patients than Previously Thought!

Abstract The escalating concern of obesity in the United States isn’t merely a statistic; it’s a palpable crisis. As of 2017-2018, the CDC noted that . The ramifications of this startling..

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Dynamic longitudinal increase in D-dimers: an early predictor of bleeding complications in ECMO

Dynamic longitudinal increase in D-dimers: an early predictor of bleeding complications in ECMO

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Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials

Abstract Background Venoarterial  (VA-ECMO) is increasingly used  with  despite the lack of evidence from adequately powered . Three trials reported so far were underpowered to detect a survival benefit; we therefore conducted an individual..

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Antithrombin III supplementation during neonatal and pediatric extracorporeal membrane oxygenation

Abstract Background Bleeding and thrombosis are common extracorporeal membrane oxygenation (ECMO) complications associated with increased mortality. Heparin is the most commonly used ECMO anticoagulant, employed in 94% of cases. Reduced..

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Mortality in Patients with Obesity and ARDS Receiving ECMO: The Multicenter ECMObesity Study

Abstract Rationale: Patients with obesity are at increased risk for developing acute respiratory distress syndrome (ARDS). Some centers consider obesity a relative contraindication to receiving extracorporeal membrane oxygenation (ECMO) support,..

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Routine ECMO in AMICS Patients Not Protective: ECLS-SHOCK

Abstract In patients with acute MI complicated by cardiogenic shock (AMICS) who are slated to undergo early revascularization, routine use of extracorporeal membrane oxygenation (ECMO) doesn’t reduce 30-day mortality. The..

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Detecting Oxygenator Thrombosis in ECMO: A Review of Current Techniques and an Exploration of Future Directions

Abstract Extracorporeal membrane oxygenation (ECMO) is a life-support technique used to treat cardiac and pulmonary failure, including severe cases of COVID-19 (coronavirus disease 2019) involving acute respiratory distress syndrome. Blood..

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Children who suffer cardiac arrest more likely to survive at ECMO capable hospitals

Abstract Children who experience cardiac arrest are one and a half times more likely to survive at a hospital capable of providing the life support system called ECMO, research suggests...

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Micellar Encapsulation of Propofol Reduces its Adsorption on Extracorporeal Membrane Oxygenator (ECMO) Circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass device used on critically ill patients with refractory heart and lung failure. Patients supported with ECMO receive numerous drugs to..

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Pilot Testing of a Lightweight, Pulmonary Assist System in an Ambulatory Sheep Model of Destination Therapy Respiratory Support

Abstract A new, lightweight (2.3 kg), ambulatory pulmonary assist system (PAS) underwent preliminary evaluation in ambulatory sheep. The PAS was purposefully designed for long-term extracorporeal respiratory support for chronic lung..

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A Simple Formula for Predicting Ventricular Distension With Venoarterial Extracorporeal Membrane Oxygenation

Abstract Left ventricular (LV) distention is a known complication of venoarterial extracorporeal membrane oxygenation (VA-ECMO) due to increased afterload stress. The consequences of LV distension include elevated pulmonary venous pressures leading to pulmonary edema and increased wall..

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Bridging the gap: safety and outcomes of intensivist-led ECMO retrievals

Abstract Purpose: Most extracorporeal membrane oxygenation (ECMO) cannulations are performed by cardiothoracic surgeons (CTS). Due to an increase in utilization of ECMO and limited availability of CTS, there is a mismatch..

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Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Abstract Background Evidence-based recommendations for transfusion in patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) are scarce. The current literature is limited to single-center studies with small sample sizes, therefore..

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Bilateral Femoral Cannulation Is Associated With Reduced Severe Limb Ischemia-Related Complications Compared With Unilateral Femoral Cannulation in Adult Peripheral Venoarterial…

Abstract Objectives:  Peripheral venoarterial extracorporeal membrane oxygenation (ECMO) with femoral access is obtained through unilateral or bilateral groin cannulation. Whether one cannulation strategy is associated with a lower risk for limb ischemia remains unknown...

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