Etiquetas Archivo: Cytokines

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A randomized trial of the inflammatory cytokines levels and the blood transfusion rate between miniaturized tubing group and conventional tubing…

Abstract Introduction We aimed to compare the inflammatory cytokines levels of the miniaturized and conventional extracorporeal circuit system. The miniaturized extracorporeal circuit system may be fewer possible inflammation-induced or blood..

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Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights

Abstract Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass (CPB) may develop several biochemical changes in the microcirculation that lead to a systemic inflammatory response. Surgical incision, post-CPB..

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Gene Expression of Inflammatory Cytokines in Major Organs by Extracorporeal Circulation

Abstract Background: Extracorporeal circulation (ECC) is indispensable for cardiac surgery. Despite the fact that ECC causes non-physiological damage to blood components, its pathophysiology has not been fully elucidated. In our..

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The Sequential Use of Extracorporeal Cytokine Removal Devices in an Adolescent With COVID-19 Receiving Continuous Renal Replacement Therapy

This case reports on an a 14-year-boy (43 kg) without any respiratory symptoms, who was admitted to a regional hospital with a fever of one day associated with vomiting and..

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Colloid Film in Optimized Extracorporeal Circulation: “A Possible Road for the Extinction of Miniaturized Cardiopulmonary Bypass”.

Abstract The inflammatory response in cardiac surgery using extracorporeal circulation (ECC) has been widely discussed in the literature with analysis on cytokines released in humans. To mitigate this response mainly..

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Hemoperfusion in the intensive care unit

Abstract Multiple organ failure following a septic event derives from immune dysregulation. Many of the mediators of this process are humoral factors (cytokines), which could theoretically be cleared by direct..

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Therapeutic Modulation of the Host Defense by Hemoadsorption with CytoSorb®—Basics, Indications and Perspectives—A Scoping Review

Abstract The “normal” immune response to an insult triggers a highly regulated response determined by the interaction of various immunocompetent cells with pro- and anti-inflammatory cytokines. Under pathologic conditions, the..

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The Effect of Low Tidal Volume Ventilation on Inflammatory Cytokines During Cardiopulmonary Bypass

Abstract Introduction: Halting ventilation during cardiopulmonary bypass (CPB) is implemented to operate in a less bleeding setting. It sustains a better visualization of the operation area and helps to perform the..

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Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis

Abstract Objectives:  Evaluating whether there is a clinical benefit of using extracorporeal cytokine adsorption therapy in two indications. Design:  Systematic review. Setting:  Search on four databases, Medline, Embase, The Cochrane..

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Antecedent ACE-inhibition, inflammatory response, and cardiac surgery associated acute kidney injury

Abstract Cardiopulmonary bypass (CPB) may trigger organs damage, including kidney injury, due to a massive cytokine release. In this observational, prospective study, we analyzed the possible impact of chronic treatment..

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RECCAS - REmoval of Cytokines during CArdiac Surgery: study protocol for a randomised controlled trial

Abstract Background On-pump cardiac surgery triggers a significant postoperative systemic inflammatory response, sometimes resulting in multiple-organ dysfunction associated with poor clinical outcome. Extracorporeal cytokine elimination with a novel haemoadsorption (HA)..

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The Impact of Lung Ventilation on Some Cytokines after Coronary Artery Bypass Grafting

Abstract Background and Aims: Cardiopulmonary bypass induces a systematic inflammatory response, which is partly understood by investigation of peripheral blood cytokine levels alone; the lungs may interfere with the net..

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Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles: A Clinical Feasibility Study

Abstract Background Removal of cytokines, chemokines, and microvesicles from the supernatant of allogeneic erythrocytes may help mitigate adverse transfusion reactions. Blood bank–based washing procedures present logistical difficulties; therefore, we tested..

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The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction

Abstract Introduction: Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory and immune response. Objective: An in-vitro model of cardiotomy suction was designed to quantify the effects of incrementally increased air-blood..

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The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction

Abstract Introduction: Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory and immune response. Objective: An in-vitro model of cardiotomy suction was designed to quantify the effects of incrementally increased air-blood..

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Hemoadsorption Treatment of Patients with Acute Infective Endocarditis during Surgery with Cardiopulmonary Bypass - A Case Series

Abstract Introduction Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery and valve replacement may be needed, posing additional risks to patients..

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