Tags Archives: Clinical trials

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Development of a New Longitudinal Ordinal Outcome for Clinical Trials in ECMO Patients

Abstract Rationale: Randomised clinical trials in intensive care often prioritize disease-focused outcomes rather than patient-centred outcomes. Objective: To report and evaluate the ‘Daily Organ Support for patients on extracorporeal membrane..

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In vitro assays and clinical trials in red blood cell aging: Lost in translation

Abstract The age of  (EC) in  and the  when transfusing long-term-stored EC are highly controversial issues. Whereas the definition of a short-term-stored EC or a long-term-stored EC is unclear in clinical trials, data..

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Cardioplegia in paediatric cardiac surgery: a systematic review of randomized controlled trials

OBJECTIVES Cardioplegia is the primary method for myocardial protection during cardiac surgery. We conducted a systematic review of randomized controlled trials of cardioplegia in children to evaluate the current evidence..

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Statistical primer: sample size and power calculations—why, when and how?

Abstract When designing a clinical study, a fundamental aspect is the sample size. In this article, we describe the rationale for sample size calculations, when it should be calculated and..

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Statistical primer: sample size and power calculations—why, when and how?

Abstract When designing a clinical study, a fundamental aspect is the sample size. In this article, we describe the rationale for sample size calculations, when it should be calculated and..

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