Tags Archives: Anticoagulation

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Efficacy of Bivalirudin for Therapeutic Anticoagulation in COVID-19 Patients Requiring ECMO Support

Abstract Objectives The  (COVID-19) pandemic has been associated with cases of refractory  (ARDS) sometimes requiring support with  (ECMO).  can be used for  in patients on ECMO support, but its efficacy and safety in patients with..

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2021 ELSO Adult and Pediatric Anticoagulation Guidelines

Abstract Anticoagulation is necessary for most pediatric and adult extracorporeal membrane oxygenation (ECMO) patients to prevent circuit clotting. Inherently, the most common side effect of anticoagulation is bleeding. Anticoagulation during..

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Antithrombin III infusion improves anticoagulation in congenital diaphragmatic hernia patients on extracorporeal membrane oxygenation

Abstract Purpose Achieving effective anticoagulation during neonatal extracorporeal membrane oxygenation (ECMO) without increasing the risk of hemorrhage remains challenging. The use of antithrombin III (AT-III) for this purpose has been..

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Bleeding and Thrombotic Events During Extracorporeal Membrane Oxygenation for Postcardiotomy Shock

Abstract Background  management during venoarterial  (ECMO) is particularly difficult in postcardiotomy shock patients given a significant bleeding risk. We sought to determine the effect of  treatment on bleeding and thrombosis risk for..

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Infective Endocarditis Is a Risk Factor for Heparin Resistance in Adult Cardiovascular Surgical Procedures: A Retrospective Study

Abstract Objectives Heparin resistance (HR), defined as a decrease in heparin responsiveness, can result in adverse events with prolonged duration of surgery. Although some clinical risk factors have been suggested,..

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Comparison of Bivalirudin Versus Unfractionated Heparin for Anticoagulation in Adult Patients on Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) contributes to coagulopathy, necessitating systemic anticoagulation to prevent thrombosis. Traditionally, unfractionated heparin (UFH) has been the anticoagulant of choice, however, due to many inadequacies new evidence suggests..

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EuroELSO Webinar: Anticoagulation monitoring on ECMO in neonates and children: moving target

  EuroELSO Webinar on 30 March 2021 Topic: Anticoagulation monitoring on ECMO in neonates and children: moving target - anti Xa over ACT & APTT.   Introduction, moderation & closing..

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Argatroban for Anticoagulation in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019

Abstract OBJECTIVES: A significant proportion of patients with coronavirus disease 2019 requiring venovenous extracorporeal membrane oxygenation at our institution demonstrated heparin resistance, which in combination with a heparin shortage resulted..

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Acute Kidney Injury and Extracorporeal Membrane Oxygenation: Review on Multiple Organ Support Options

Abstract Extracorporeal membrane oxygenation (ECMO) is a temporary life support system used to assist patients with life-threatening severe cardiac and/or respiratory insufficiency. Patients requiring ECMO can be considered the sickest..

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Severe thrombocytopenia in adults undergoing extracorporeal membrane oxygenation is predictive of thrombosis

Abstract Extracorporeal membrane oxygenation (ECMO) provides lifesaving circulatory support and gas exchange, although hematologic complications are frequent. The relationship between ECMO and severe thrombocytopenia (platelet count <50 × 109/L) remains ill-defined. We performed..

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Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week

Abstract Hemostasis and thrombosis are believed to be so intricately linked that any strategies that reduce thrombosis will have an inevitable impact on hemostasis. Consequently, bleeding is viewed as an unavoidable..

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Use of bivalirudin for anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO)

Abstract This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving bivalirudin were compared to patients receiving heparin as the anticoagulant on ECMO...

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Neonatal respiratory and cardiac ECMO in Europe

Abstract Neonatal extracorporeal membrane oxygenation (ECMO) is a life-saving procedure for critically ill neonates suffering from a potentially reversible disease, causing severe cardiac and/or respiratory failure and refractory to maximal..

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Comparison of Clinical Scoring Tools to Predict Heparin-Induced Thrombocytopenia in Cardiac Surgery

Abstract The 4Ts and HIT-Expert Probability (HEP) scoring tools for heparin-induced thrombocytopenia (HIT) have not been validated in cardiac surgery patients, and the reported sensitivity and specificity of the Post-Cardiopulmonary..

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Anticoagulation and Transfusion Management During Neonatal and Pediatric Extracorporeal Membrane Oxygenation: A Survey of Medical Directors in the United States

Abstract OBJECTIVES:  To compare current practices within the United States of anticoagulation management and blood transfusion in neonatal and pediatric extracorporeal membrane oxygenation patients with a 2013 international report. DESIGN: ..

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Comparison of Anticoagulation Strategies in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation: Heparin Versus Bivalirudin

Abstract OBJECTIVES:  Extracorporeal membrane oxygenation is a life-sustaining therapy for severe respiratory failure. Extracorporeal membrane oxygenation circuits require systemic anticoagulation that creates a delicate balance between circuit-related thrombosis and bleeding-related..

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Bivalirudin May Reduce the Need for Red Blood Cell Transfusion in Pediatric Cardiac Patients on Extracorporeal Membrane Oxygenation

Abstract We retrospectively compared anticoagulation with heparin and bivalirudin for 32 consecutive children under 18 years old during extracorporeal membrane oxygenation (ECMO) in our pediatric cardiac intensive care unit (PCICU). Between September..

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Anticoagulation and In-Hospital Mortality From Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

Abstract Hypercoagulability in coronavirus disease 2019 (COVID-19) may aggravate disease severity during hospitalization but the reported survival benefits from anticoagulation (AC) vary among studies. We performed a literature research to..

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Antiphospholipid Syndrome and Cardiac Bypass: The Careful Balance between Clotting and Bleeding

Abstract Antiphospholipid syndrome (APS) is an acquired autoimmune condition characterized by the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibody, and anti-β2 glycoprotein-I antibody) which leads to clinical thrombosis via a..

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Low vs standardized dose anticoagulation regimens for extracorporeal membrane oxygenation: A meta-analysis

Abstract Background To compare the safety and efficacy of low-dose anticoagulation (LA) with that of standardized dose anticoagulation (SA) for patients supported with extracorporeal membrane oxygenation (ECMO). Methods PubMed, MEDLINE,..

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Hypercoagulopathy, acquired coagulation disorders and anticoagulation before, during and after extracorporeal membrane oxygenation in COVID-19: a case series.

Abstract Background: Thromboembolism and bleeding contribute to Coronavirus disease 2019 (COVID-19)’s morbidity and mortality and are also frequent complications of venovenous extracorporeal membrane oxygenation (vvECMO). As the interaction of the..

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ECMO and anticoagulation management.

The learner will be able to discuss anticoagulation strategies for patients on ECMO.   

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ECMO. Joe Basha, CCP July 19, 2018

ECMO: Measurement Of Adequacy, Cannulation, North/South Complication, Anticoagulation And Weaning, And What Patients Can Be Woken Up And Extubated On VV ECMO?   

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Novel approach to measuring clot burden of an oxygenator during ECMO.

Joe presents data on the commonality of clot burden in the ECMO circuit and how difficult it is to detect without a tool that can directly measure intra-oxygenator volume in..

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Extracorporeal Membrane Oxygenation (ECMO) Anticoagulation.

Joe Basha, CCP and John Ingram, CCP talk about anticoagulation strategies for ECMO patients.  Joe and John discuss SCCM guidelines and their own experiences with different anticoagulation protocols.   

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Extracorporeal Membrane Oxygenation (ECMO) Anticoagulation.

Joe Basha, CCP and John Ingram, CCP talk about anticoagulation strategies for ECMO patients.  Joe and John discuss SCCM guidelines and their own experiences with different anticoagulation protocols.   

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Heparin Free (VV ECMO) Veno Venous Extracorporeal Membrane Oxygenation in a Multiple Trauma Patient

Tammy Sparacino Journal Club - John Ingram Knowledge Nuggets  Tammy Sparacino Journal Club: Heparin - free ( VV ECMO) Veno - Venous Extracorporeal Membrane Oxygenation in a multiple trauma patient:..

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ECMO and anticoagulation management

The learner will be able to discuss anticoagulation strategies for patients on ECMO.   

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2020 Acute Coronary Syndromes (ACS) in Patients Presenting without Persistent ST-Segment Elevation (Management of).Guidelines

Preamble Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and..

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Anticoagulation and Transfusion Management During Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Objectives:  To compare current practices within the United States of anticoagulation management and blood transfusion in neonatal and pediatric extracorporeal membrane oxygenation patients with a 2013 international report. Design: ..

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