Tags Archives: Acute kidney injury (AKI)

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Pulsatile cardiopulmonary bypass using a centrifugal pump reduces acute kidney injury after cardiac surgery: a propensity score-matched analysis

Abstract Objective Acute kidney injury (AKI) affects approximately 30% of patients undergoing cardiac surgery with conventional non-pulsatile cardiopulmonary bypass (CPB). Pulsatile flow has long been proposed for mitigating this complication...

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Implementation of a goal directed perfusion strategy to reduce cardiac surgery associated kidney injury: A before and after study

Abstract Purpose Cardiac surgery associated acute kidney injury (CSA-AKI) is a frequent and severe complication. Goal Directed Perfusion (GDP) during cardiopulmonary bypass (CPB) has been developed to reduce post-operative complications,..

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How Would We Prevent Our Own Acute Kidney Injury After Cardiac Surgery?

Abstract Acute Kidney Injury (AKI) is a common complication after cardiac surgery affecting up to 40% leading to increased morbidity and mortality. To date, there is no specific treatment for..

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Kidney replacement therapy during extracorporeal membrane oxygenation: pathophysiology, technical considerations, and outcomes

Abstract The use of extracorporeal membrane oxygenation has been increasing over time, in part due to the COVID-19 pandemic. Whilst lifesaving, complications that must be managed are also associated with..

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Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER-trial): a Randomized…

Abstract Background:  Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic kidney disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed...

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Perioperative Bleeding Is Not an Independent Risk Factor for Acute Kidney Injury in On-pump Cardiac Surgery—A Post-hoc Analysis of a…

Abstract Objectives To study the association between bleeding and acute kidney injury (AKI). Design Post-hoc study of a randomized trial of 4% albumin versus Ringer's acetate for cardiopulmonary bypass priming..

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Fenoldopam use during Cardiopulmonary Bypass and Postoperative Rates of Acute Kidney Injury.

Abstract Acute kidney injury (AKI) is a complex clinical syndrome with a spectrum of clinical manifestations and outcomes (1); characterized by the deterioration of renal function over a period of..

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Goal-directed Perfusion to Reduce Acute Kidney Injury After Pediatric Cardiac Operation

Abstract Background Although goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) has been discussed extensively in adult studies, no pediatric indexed oxygen delivery (Do2i) thresholds are universally accepted, and no pediatric..

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The Association Between Platelet Transfusion and Acute Kidney Injury Following Fontan Surgery

Abstract Objectives: Previous studies have demonstrated an association between transfusion and increased organ dysfunction. We sought to determine the association between transfusion of blood components (red blood cell [RBC], plasma, platelet,..

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Kidney Injury under Diminished Pulsatile Flow Induced by V-A ECMO in Sheep

Abstract Extracorporeal membrane oxygenation (ECMO) is commonly used for critically ill patients and associated with high rates of kidney injury and mortality. This study aimed to assess the impact of..

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Synthetic colloids as priming fluids in cardiopulmonary bypass and postoperative acute kidney injury: a propensity score-matched study

Abstract Background The optimal fluid management strategy for patients undergoing on-pump cardiac surgery was controversial regarding the fluid types. This study aimed to compare the impact of hydroxyethyl starch (HES)..

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Predictive value of the triglyceride-glucose index for coronary artery bypass grafting-acute kidney injury patients

Abstract Background Acute kidney injury (AKI) is a common and serious complication after coronary artery bypass grafting (CABG), significantly affecting patient outcomes. The triglyceride-glucose (TyG) index, a marker of insulin..

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Renal macro- and microcirculatory perturbations in acute kidney injury and chronic kidney disease associated with heart failure and cardiac surgery

Abstract Chronic kidney disease (CKD) affects 50% of patients with heart failure. The pathophysiology of CKD in heart failure is proposed to be driven by macrocirculatory hemodynamic changes, including reduced..

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Urine biomarkers, acute kidney injury, and fluid overload in neonatal cardiac surgery

Abstract Background:Cardiac surgery-associated acute kidney injury (CS-AKI) and fluid overload (FO) are common among neonates who undergo cardiopulmonary bypass, and increase mortality risk. Current diagnostic criteria may delay diagnosis. Thus,..

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Research progress on the pathogenesis of AKI complicated by ECMO

Abstract Background Extracorporeal membrane oxygenation (ECMO) stands as a pivotal intervention for patients grappling with cardiopulmonary insufficiency. However, alongside its therapeutic benefits, ECMO carries the risk of complications, with acute..

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Preoperative vascular dysfunction is associated with acute kidney injury after cardiac surgery

Abstract Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) results in poor prognosis. Several risk factors for CSA-AKI have been reported, including preoperative creatinine level, cardiopulmonary bypass time, and perioperative blood pressure..

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Combining cardiac and renal biomarkers to establish a clinical early prediction model for cardiac surgery-associated acute kidney injury: a prospective…

Abstract Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a prevalent complication with poor outcomes, and its early prediction remains a challenging task. Currently available biomarkers for acute kidney injury (AKI)..

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The Potential Role of Albumin in Reducing Cardiac Surgery–Associated Acute Kidney Injury: A Randomized Controlled Trial

Abstract Objectives Cardiac surgery–associated acute kidney injury (CSA-AKI) is a common complication with high morbidity and mortality. This study was designed to determine whether adding human albumin to the cardiopulmonary..

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Prebypass Critical Closing Pressure Predicts Acute Kidney Injury After Cardiopulmonary Bypass

Abstract Objectives Optimal blood pressure goals during cardiopulmonary bypass (CPB) remain uncertain and new metrics to individualize perfusion targets are needed. Critical closing pressure (Pcrit) is a fundamental property of..

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Development of and recovery from acute kidney injury after cardiac surgery: Randomized phase 2 trial of the hepatocyte growth factor…

Abstract Objectives To investigate the safety and efficacy of ANG-3777, a hepatocyte growth factor mimetic, in mitigating the risk of acute kidney injury (AKI) in patients undergoing cardiac surgery with..

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Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding

Abstract Around one-quarter of all patients undergoing cardiac procedures, particularly those on cardiopulmonary bypass, develop cardiac surgery-associated acute kidney injury (CSA-AKI). This complication increases the risk of several serious morbidities..

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Near-infrared spectroscopy combined with vascular occlusion test to predict acute kidney injury in patients undergoing cardiac surgery: a prospective observational…

Abstract Background Near-infrared spectroscopy (NIRS) enables a non-invasive measurement of tissue oxygen saturation (StO2) in regions illuminated by near-infrared lights. Vascular occlusion test (VOT) serves as a model to artificially..

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Acute kidney injury

Abstract Acute kidney injury (AKI) is a common, heterogeneous, multifactorial condition, which is part of the overarching syndrome of acute kidney diseases and disorders. This condition's incidence highest in low-income..

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Preoperative Serum Ferritin Level and Acute Kidney Injury after Pediatric Cardiac Surgery

Abstract Background Acute kidney injury (AKI) is a significant complication in pediatric patients undergoing cardiac surgery. Iron metabolism-related indicators such as ferritin may predict AKI after adult cardiac surgery. However, it..

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Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION…

Abstract Background:  In the PROTECTION trial, intravenous amino acids (AA) decreased the occurrence of acute kidney injury (AKI) in cardiac surgery patients with cardiopulmonary bypass (CPB). Recruitment of renal functional..

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Prediction of Acute Kidney Injury After Cardiac Surgery With Combined Arterial and Venous Intrarenal Doppler

Abstract Background: Acute kidney injury (AKI) occurs in up to 50% of cardiac surgical patients and is often hemodynamically mediated. Point-of-care ultrasound is a non-invasive tool that has the potential..

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Intravenous Amino-acid Infusion to Prevent Acute Kidney Injury after Cardiac Surgery: A Review of the Evidence

Abstract Background Acute kidney injury (AKI) is a frequent and important complication of cardiac surgery. Decreased perfusion is a key mechanism. This decreased perfusion may be attenuated by intravenous amino..

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Minimizing Acute Kidney Injury in Pediatric Cardiac Surgery: Incidence, Early Detection, and Preemptive Measures

Abstract Background Acute kidney injury (AKI) poses a significant challenge in pediatric cardiac surgery, having a profound impact on patient morbidity and mortality. This study aims to determine the incidence..

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A model for predicting AKI after cardiopulmonary bypass surgery in Chinese patients with normal preoperative renal function

Abstract Objective To develop and validate a predictive model for acute kidney injury (AKI) after cardiopulmonary bypass (CPB) surgery in Chinese patients with normal preoperative renal function. Method From January..

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Acute kidney disease and postoperative glycemia variability in patients undergoing cardiac surgery: A multicenter cohort analysis of 8,090 patients

Abstract Background No previous research has specifically investigated the relationship between postoperative glycemic variability (GV) and acute kidney disease (AKD) in patients undergoing cardiac surgery. In this study, several methods..

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