Pediatric

Perfusfind S.L.

Abstract Remote ischemic preconditioning (RIPreC) has been regarded as a promising strategy to reduce ischemia-reperfusion injury to the heart and other organs caused by cardiopulmonary bypass. While RIPreC has demonstrated potential benefits in adult cardiac surgery, particularly in reducing postoperative kidney and cardiac dysfunction, evidence in pediatric populations remains limited..

Perfusfind S.L.

Abstract Introduction Neonatal aortic arch surgery is associated with neurological morbidity of varying severity which is detected and potentially limited through neuroprotective strategies. We conducted a survey of healthcare professionals at all neonatal cardiac surgery centres in the United Kingdom and Ireland to determine current intraoperative neuromonitoring and neuroprotection practice...

Perfusfind S.L.

Abstract Low cardiac output syndrome (LCOS) is defined by an insufficient cardiac output to meet metabolic demands, leading to tissue hypoperfusion and potential organ dysfunction. Although it affects up to 42% of neonates after cardiac surgery with cardiopulmonary bypass (CPB), pharmacological prevention practices vary widely, with limited supporting evidence.,, Surveys such as EuLoCOS-Paed..

Perfusfind S.L.

Abstract Objective This study evaluated thrombus formation and its impact on outcomes in neonates and early infants undergoing congenital heart surgery. Methods Neonates and early infants (≤90 days) undergoing congenital heart surgery with cardiopulmonary bypass from 2001 to 2024 were analyzed. Thrombi were detected by transthoracic echocardiography and cardiac catheterization...

Perfusfind S.L.

Abstract Background Mortality in congenital diaphragmatic hernia (CDH) approximates 30 %. Both severe lung hypoplasia and other anomalies contribute to demise regardless of repair and/or extracorporeal membrane oxygenation (ECMO). We report clinical and physiological parameters for CDH infants not offered repair or ECMO (NoR/ECMO). Methods A single center retrospective analysis..

Perfusfind S.L.

Abstract Background Maintaining optimal anesthetic depth during cardiopulmonary bypass (CPB) in pediatric patients is challenging due to altered physiology and unreliable conventional monitoring. Entropy, a processed electroencephalogram metric, offers a potential solution. This study aimed to evaluate the relationship between end oxygenator sevoflurane concentration and entropy values during pediatric CPB..

Perfusfind S.L.

Abstract Background Open cardiac surgery involving cardiopulmonary bypass (CPB) triggers a systemic inflammatory response that significantly affects clinical outcomes. However, the dynamics and specific roles of cytokine release after CPB in the pediatric population remain unclear. Purpose To evaluate the dynamics of cytokine levels and their association with low cardiac..

Perfusfind S.L.

Abstract Background Health-related  (HRQL) is an important outcome measure in . We aimed to determine HRQL of children who underwent complex cardiac surgery at age ≤6 weeks with follow-up at age 4-5 years. Methods We prospectively followed an inception cohort of children after complex cardiac surgery (CCS) performed at age ≤6 weeks..

Perfusfind S.L.

Abstract Background: The applicability of four major traditional in-hospital mortality models in the Chinese setting is unclear due to disease spectrum and population heterogeneity. This study aimed to test the performance of these models in the Chinese setting and to construct and externally validate a novel model. Methods: A total..

Perfusfind S.L.

Abstract Objective:This study aimed to evaluate school-age neurodevelopmental outcomes among children with single ventricle heart disease who underwent neonatal Norwood operation with regional cerebral perfusion compared to deep hypothermic circulatory arrest. Additionally, we aimed to identify predictors of school-age development, including early developmental measures. Study design:Patients enrolled in a prospective..