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Antithrombin restriction in extracorporeal membrane oxygenation support (ARES): A multidisciplinary approach

Abstract Background:   Antithrombin (AT) replacement is occasionally utilized in the setting of extracorporeal membrane oxygenation (ECMO)-associated heparin resistance. Although past studies emphasized the high costs and limited clinical benefit..

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Criteria for Defining Stages of Cardiogenic Shock Severity

Abstract Background Risk-stratifying patients with  (CS) is a major unmet need. The recently proposed Society for Cardiovascular  and Interventions (SCAI) staging system for CS severity lacks uniform criteria defining each stage. Objectives..

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Analysis of the 2023 European Multidisciplinary Consensus Statement on the Management of Short-term Mechanical Circulatory Support of Cardiogenic Shock in…

Abstract DESPITE MEDICAL ADVANCEMENTS, mortality in cardiogenic shock (CS) remains unacceptably high.The decreased cardiac output resulting in impaired oxygen delivery characteristic of CS triggers a dismal cascade culminating in tissue..

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The prevalence of alloantibodies and ABO RhD blood groups in a cohort of Aboriginal and non-Aboriginal cardiac surgery patients from…

Abstract Introduction Limited evidence exists on the distribution of ABO RhD blood groups and prevalence and specificity of red blood cell (RBC) alloantibodies in Aboriginal and Torres Strait Islander peoples..

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A precise blood transfusion evaluation model for aortic surgery: a single-center retrospective study

Abstract Cardiac aortic surgery is an extremely complicated procedure that often requires large volume blood transfusions during the operation. Currently, it is not possible to accurately estimate the intraoperative blood..

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Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations

Abstract Acute kidney injury (AKI) is a complex and life-threatening condition with multifactorial etiologies, ranging from ischemic injury to nephrotoxic exposures. Management is founded on treating the underlying cause of..

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A Deep Learning Framework for Predicting Patient Decannulation on Extracorporeal Membrane Oxygenation Devices: Development and Model Analysis Study

Abstract Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a therapy for patients with refractory respiratory failure. The decision to decannulate someone from extracorporeal membrane oxygenation (ECMO) often involves weaning trials..

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Impact of extracorporeal haemoadsorption during prolonged cardiopulmonary bypass on the incidence of acute kidney injury

Abstract The usage of cardiopulmonary bypass (CPB) in cardiothoracic surgery contributes to the activation of the inflammatory response. In certain cases, the systemic inflammatory response may be immoderate, leading to..

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Factor Eight Inhibitor Bypassing Activity as First-line Therapy for Coagulopathy in Cardiac Surgery

Abstract Objectives To compare the outcomes of factor eight inhibitor bypassing activity (FEIBA) versus fresh frozen plasma (FFP) as the primary treatment for postoperative coagulopathy in patients undergoing cardiac surgery...

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Comparing Outcomes of Post-Cardiotomy Cardiogenic Shock Patients: On-Site Cannulation vs. Retrieval for V-A ECMO Support

Abstract Background:    Post-cardiotomy cardiogenic shock (PCCS) remains a life-threatening complication after cardiac surgery. Extracorporeal membrane oxygenation (ECMO) represents the mainstay of mechanical circulatory support for PCCS; however, its availability..

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Practitioner dashboard feedback improves glycemic but not temperature compliance during cardiac surgery: A single center retrospective analysis

Abstract Study Objective To determine the association of practitioner dashboard feedback of intraoperative  and temperature control on maintenance of  and normothermia. Design Retrospective review. Setting Single  institution. Patients Patients over the age of..

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HEMA-Lysine-Based Cryogels for Highly Selective Heparin Neutralization

Abstract Unfractionated heparin (UFH) and its low-molecular-weight fragments (LMWH) are widely used as anticoagulants for surgical procedures and extracorporeal blood purification therapies such as cardiovascular surgery and dialysis. The anticoagulant..

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An Atraumatic Mock Loop for Realistic Hemocompatibility Assessment of Blood Pumps

Abstract Objective: Conventional mock circulatory loops (MCLs) cannot replicate realistic hemodynamic conditions without inducing blood trauma. This constrains in-vitro hemocompatibility examinations of blood pumps to static test loops that do..

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Anti-Xa-guided Anticoagulation With Unfractionated Heparin and Thrombosis During Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-analysis

Abstract Objective The initiation of extracorporeal membrane oxygenation (ECMO) triggers complex coagulation processes necessitating systemic anticoagulation. Therefore, anticoagulation monitoring is crucial to avoid adverse events such as thrombosis and hemorrhage...

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Sex-specific troponin and creatine kinase thresholds after coronary bypass surgery

Abstract BACKGROUND The impact of sex-differences on the release of cardiac biomarkers after coronary artery bypass grafting (CABG) remains unknown. The aim of our study was to (a) investigate the..

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Multifaceted Intervention to Improve Patient Safety Incident Reporting in Intensive Care Units

Abstract Objectives  Patient safety incident reporting in our institution’s intensive care units (ICUs) had fallen 30% below national benchmarks during the COVID-19 pandemic. Underreporting diminishes awareness of risks and precludes..

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Risk prediction strategies using intraoperative physiological data in adults undergoing surgery: a systematic review study protocol

Abstract Postoperative mortality accounts for 7.7% of all global deaths, while postoperative complications increase 1-year mortality by 60%. Risk prediction models for postoperative complications and mortality can facilitate tailored risk..

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Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial

Abstract Purpose After cardiac surgery, fluid bolus therapy (FBT) with 20% human albumin may facilitate less fluid and vasopressor administration than FBT with crystalloids. We aimed to determine whether, after..

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Platelet-Rich Plasma Sequestration in Cardiac Surgery in a Jehovah's Witness

Abstract JEHOVAH'S WITNESSES (JW) refuse allogeneic blood transfusions because of their religious beliefs, a situation that poses significant challenges in the context of cardiac surgery, given that bleeding-related complications may..

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Intra-aortic balloon pump treatment in an adult patient with a Fontan circulation and acute heart failure: a case report

Abstract Background There is limited evidence for the use of an intra-aortic balloon pump (IABP) in adult patients with a total cavopulmonary, or Fontan circulation. Case summary A patient in..

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Heparin-Induced Thrombocytopenia (HIT) in the Direct Oral Anticoagulants (DOAC) Era

Abstract Background Heparin-induced thrombocytopenia (HIT) is an uncommon complication of heparin therapy with significant risk for severe morbidity and mortality. We investigated the role and outcome of direct oral anticoagulants..

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Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units

Abstract Importance  Centralizing deceased organ donor management and organ recovery into donor care units (DCUs) may mitigate the critical organ shortage by positively impacting donation and recipient outcomes. Objective  To compare donation..

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Quantifying potential fluid transfused through pressure monitoring and circuit flushes in pediatric ECMO patients

Abstract Pressure monitoring on pediatric Extracorporeal Membrane Oxygenation (ECMO) circuits is used to aid in the evaluation of patient hemodynamics and circuit health. Extracorporeal Life Support Organization (ELSO) recommends monitoring..

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Easy flow: An eclectic cardiopulmonary bypass simulation model

Abstract The aphorism “Primum non nocere” underscores the responsibility of healthcare professionals to prioritize patient safety. Perfusionists, experts in extracorporeal circulation, play a pivotal role in maintaining cardiac function during..

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Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials

Abstract Purpose The development of acute kidney injury (AKI) after the acute respiratory distress syndrome (ARDS) reduces the chance of organ recovery and survival. The purpose of this study was..

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Dual-Lumen Extracorporeal Membrane Oxygenation Cannulation Technique Using Only Transthoracic Echocardiography – A Case Series

Abstract Background Bicaval dual lumen cannula (DLC) is gaining popularity in veno-venous extracorporeal membrane oxygenation (V-V ECMO) for having less recirculation and facilitating mobilization. It is usually inserted under fluoroscopic..

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Use of Intravenous Albumin

Abstract Background Albumin is used commonly across a wide range of clinical settings to improve hemodynamics, to facilitate fluid removal, and to manage complications of cirrhosis. The International Collaboration for..

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First initiation of mobilization out of bed after cardiac surgery – an observational cross-sectional study in Sweden

Abstract Background Cardiac surgery is associated with a period of postoperative bed rest. Although early mobilization is a vital component of postoperative care, for preventing complications and enhancing physical recovery,..

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In Vitro Investigation of Insulin Dynamics During 4 Hours of Simulated Cardiopulmonary Bypass

Abstract BACKGROUND:  Hyperglycemia is common in patients undergoing cardiovascular surgery with cardiopulmonary bypass. We hypothesize that intraoperative hyperglycemia may be, at least partially, attributable to insulin loss due to adhesion..

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Intraoperative Glucose and Kidney Injury After On-Pump Cardiac Surgery: A Retrospective Cohort Study

Abstract Introduction Acute kidney injury (AKI) is a common complication after on-pump cardiac surgery, and previous studies have suggested that blood glucose is associated with postoperative AKI. However, limited evidence..

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