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The mystery of methylene blue and its role in managing post-cardiac surgery vasoplegic shock

Abstract Background Vasoplegic syndrome is associated with high mortality. Methylene blue (MB) is a guanylate cyclase inhibitor that ameliorates this re-distributive type of shock. This study aims to investigate the..

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Oxygen delivery and carbon dioxide removal on venovenous extracorporeal membrane oxygenation

Abstract Purpose of review  Venovenous extracorporeal membrane oxygenation (VV-ECMO) provides gas exchange for patients with advanced respiratory failure who cannot maintain adequate oxygenation or carbon dioxide (CO2) clearance through conventional..

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Research progress on the pathogenesis of AKI complicated by ECMO

Abstract Background Extracorporeal membrane oxygenation (ECMO) stands as a pivotal intervention for patients grappling with cardiopulmonary insufficiency. However, alongside its therapeutic benefits, ECMO carries the risk of complications, with acute..

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PerfWeb 101 (5 days event) - 1/3 April

  Day 1 - Organ Transplant Availability, Procurement & OCS Insights   Day 2 - NRP (Normothermic Regional Perfusion)   Day 3 - Raging Fireside Chat on Transplant Perfusion Challenges..

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PerfWeb 100

  Day 1 - Essential Techniques in Perfusion - RAPP and Hgb Thresholds   Day 2 - Mastering Ultrafiltration & Fluid Balance in Perfusion; Essential Techniques & Insights   Day..

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Can utilization of the venous-to-arterial carbon dioxide difference improve patient outcomes in cardiogenic shock? A narrative review

Abstract Cardiogenic shock (CS) is a critical condition with high mortality, characterized by reduced cardiac output (CO) and tissue hypoperfusion, despite advancements in treatment. Traditional hemodynamic markers like CO measurements,..

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Implementation of a Multidisciplinary Team for Initiation of Extracorporeal Cardiopulmonary Resuscitation in Patients Presenting After Out-of-hospital Cardiac Arrest

Abstract Objectives Patents with out-of-hospital cardiac arrest (OHCA) are at high risk of death or poor neurologic recovery if spontaneous circulation is not rapidly restored. Emergent mechanical circulatory support with..

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Short-Term Mechanical Circulatory Support for Cardiogenic Shock eBook

Overview SCAI’s eBook on Mechanical Circulatory Support (MCS) provides an in-depth, structured approach to understanding cardiogenic shock and the use of MCS devices. Organized into five sections, the eBook covers..

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Novel technique of heart and lung as liver harvesting

Novel technique of heart and lung as liver harvesting with one shot retrograde cardioplegia.   Dr.Sam Zeraatian Nejad Davani, CEO of rockingham medical research ADKWA center as well as Head..

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Obesity and Venoarterial Extracorporeal Membrane Oxygenation Outcomes: The Plot Thickens

Abstract We read with great interest a recent article on the association between body mass index (BMI) and outcomes in patients supported by venoarterial extracorporeal membrane oxygenation (VA-ECMO). In a review..

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Use of the measurement tools of TeamSTEPPS®: a scoping review

Abstract Background TeamSTEPPS® (Team Strategies and Tools to Enhance Performance and Patient Safety) is an evidence-based program developed to train healthcare professionals working in any environment where communication and teamwork are..

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Survey of Extracorporeal Life Support Application in Lung Transplantation

Abstract Introduction Lung transplantation has been evolving since its inception in 1963. Over recent years, literature has suggested a shift in the perioperative strategy of mechanical support toward extracorporeal membrane..

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Does methylene blue improve outcomes in patients with post-cardiac surgery vasoplegic syndrome?

Abstract OBJECTIVES A best evidence topic was written according to a structured protocol described in ICVTS. The question addressed was ‘In patients with vasoplegic syndrome following cardiac surgery with cardiopulmonary bypass,..

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Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations

Abstract Background Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to..

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Incidence of neutrophil extracellular traps (NETs) in different membrane oxygenators: pilot in vitro experiments in commercially available coated membranes

Abstract Neutrophil extracellular traps (NETs) were detected in blood samples and in cellular deposits of oxygenator membranes during extracorporeal membrane oxygenation (ECMO) therapy and may be responsible for thrombogenesis. The..

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Blood Purification Membranes Used in Liquid–Gas Environments: Artificial Lungs

Abstract Extracorporeal membrane oxygenation (ECMO), the key component of which is a membrane oxygenator, known as the artificial lung, could provide irreplaceable respiratory support for patients with cardiopulmonary failure. The..

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Anticoagulation Monitoring Strategies During Extracorporeal Membrane Oxygenation (ECMO) Therapy – Differences Between Simultaneously Obtained Coagulation Tests: A Retrospective Single-Center Cohort…

Abstract Introduction During extracorporeal membrane oxygenation (ECMO) systemic anticoagulation with unfractionated heparin (UFH) is standard-of-care. However, there is uncertainty regarding optimal anticoagulation monitoring strategies. Methods We retrospectively investigated venovenous and..

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From GPT to DeepSeek: Significant gaps remain in realizing AI in healthcare

Abstract Introduction On January 27, 2025, DeepSeek-R1, a new Generative AI model, was introduced and rapidly gained adoption, taking over the user market to become the No.1 downloaded AI app , , ...

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Daily Surveillance Blood Cultures in Children Supported With Extracorporeal Membrane Oxygenation: Single-Center, Retrospective Cohort Study, 2021–2023

Abstract Objective:  Diagnosing bloodstream infections (BSIs) in patients on extracorporeal membrane oxygenation (ECMO) can be challenging due to circuit-controlled temperature, altered hemodynamics, and questionable reliability of inflammatory markers in critically..

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Perioperative extracorporeal membrane oxygenation in neonates with transposition of the great arteries: 15 years of experience

Abstract OBJECTIVES Extracorporeal membrane oxygenation (ECMO) can act as a bridge to recovery in both pre- and postoperative patients with transposition of the great arteries (TGA). However, literature on its..

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The Ross/Konno Procedure

Left ventricular outflow tract obstruction in neonates and infants encompasses a variety of anatomical defects, ranging from isolated aortic valve stenosis or discrete subaortic stenosis to the more complex tunnel..

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ECMO in Resource-Limited Settings: Challenges and the Way Forward

Introduction Extracorporeal Membrane Oxygenation (ECMO) has revolutionized the management of patients with severe cardiac and respiratory failure. Once considered a last-resort therapy, ECMO is now an integral part of critical..

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Customized Priming Strategies for High-Risk Patients: Pediatric, Geriatric, and Renal Compromise Considerations.

Introduction Cardiopulmonary bypass (CPB) is essential in cardiac surgery, but high-risk patients—such as pediatric, geriatric, and renal-compromised individuals—require specialized priming strategies to optimize outcomes. A one-size-fits-all approach can lead to..

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Hemodynamic Management During Cardiopulmonary Bypass

Introduction Cardiopulmonary bypass (CPB) is a critical component of cardiac surgery, allowing the heart to be temporarily stopped while maintaining circulation and oxygenation. Proper hemodynamic management during CPB is essential..

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Optimizing Priming Solutions in Cardiopulmonary Bypass: Balancing Hemodynamics, Organ Protection, and Patient Outcomes

Introduction Cardiopulmonary bypass (CPB) is a life-saving technology that temporarily replaces the heart and lungs during cardiac surgery. The choice of priming solution plays a crucial role in maintaining hemodynamic..

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Cardioplegia: Classification, Evolution, and Strategies to Reduce Reperfusion Injury

1. Introduction Cardioplegia plays a crucial role in myocardial protection during cardiac surgery by inducing controlled cardiac arrest and minimizing ischemic injury. Over the years, various cardioplegia strategies have evolved,..

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Isolated Limb Perfusion (ILP) and Hyperthermia in Cancer Treatment

Introduction Isolated Limb Perfusion (ILP) is a targeted chemotherapy technique used primarily for treating locally advanced limb malignancies, such as soft tissue sarcomas and melanoma. By isolating the limb’s vascular..

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Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Revolutionary Approach in Oncologic Perfusion

Introduction Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is an advanced oncologic perfusion technique designed to treat peritoneal carcinomatosis, a condition where cancer spreads within the peritoneal cavity (Sugarbaker, 1995). This innovative approach..

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Left Heart Bypass

Left Heart Bypass: An Overview Introduction Left Heart Bypass (LHB) is a surgical technique used to temporarily divert blood from the left side of the heart to maintain distal perfusion..

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The Untold Story of Cardiac Surgery in Pakistan.

Introduction The history of cardiac surgery in Pakistan is often credited to various institutions, but a lesser-known and largely undocumented fact is that the first open-heart surgery in Pakistan was..

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