Abstract Background/Objectives: Cardiopulmonary bypass (CPB) induces a systemic inflammatory response that may contribute to postoperative organ dysfunction. However, the effects of pulsatile and non-pulsatile CPB on the inflammatory response remain..
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Abstract Purpose Ultrafiltration (UF) reduces dilution of all blood components during cardiopulmonary bypass (CPB), but its impact on coagulation performance remains unclear. We examined whether conventional UF mitigates the CPB-induced..
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Abstract Introduction Extracorporeal membrane oxygenation (ECMO) provides life-sustaining gas exchange and haemodynamic support for critically ill patients with severe respiratory or circulatory failure. Paediatric patients supported on ECMO often represent..
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Abstract Background and Objectives: Myocardial protection during on-pump coronary artery bypass grafting (CABG) limits ischaemic injury, particularly in patients with left main coronary artery disease (LMCAD), in whom severe proximal..
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Abstract Failure of extracorporeal membrane oxygenation (ECMO) circuit components can precipitate abrupt hemodynamic or respiratory collapse; however, the evidence linking specific component malfunctions to patient harm remains sparse, and device-specific..
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Abstract Background: Extracorporeal membrane oxygenation (ECMO) provides life support to patients undergoing cardiopulmonary surgeries when other interventions are ineffective. Unfractionated heparin (UFH) is routinely used during ECMO due to the..
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Abstract Background Operating a cardiopulmonary bypass (CPB) system requires high-level multitasking while simultaneously maintaining continuous situation awareness. Among these, venous reservoir level is particularly critical. This level is monitored using..
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Abstract Precise control of dissolved oxygen is essential for reproducing physiologically relevant conditions in microfluidic cell culture systems. Here, we present a standalone, polydimethylsiloxane-free gas exchange unit (GEU) which enables..
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Abstract Venovenous extracorporeal membrane oxygenation (VV ECMO) candidacy decision-making processes vary within and between centers. An underexplored potential contributor to this variability is the care model. Fundamental differences in infrastructure,..
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Abstract Measles is resurgent worldwide, and although vaccine-preventable, severe disease can progress to cardiorespiratory failure refractory to conventional support. This study aimed to determine whether extracorporeal membrane oxygenation (ECMO) is..
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Abstract Objectives To identify if the delivery of oxygen over consumption of oxygen (DO2/VO2) ratio is significantly associated with clinical outcomes such as mortality, need for heart transplantation, or need..
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Abstract Background. Cerebral autoregulation (CA) is estimated by assessing the association between variations of mean cerebral blood velocity (MCBv) and mean arterial pressure (MAP). Recently, regional oxygen saturation (rSO2) has..
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Abstract Introduction Aortic arch repair following the Norwood operation remains challenging because of dense adhesions and the risk of phrenic or recurrent nerve injury. We present a novel approach employing..
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Abstract Background In aortic arch surgery, bilateral selective antegrade cerebral perfusion (bSACP) maintains cerebral blood flow during circulatory arrest. bSACP is often delivered using a single pump with a Y-connector,..
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Abstract Background Antegrade cerebral perfusion (ACP) is widely used during congenital aortic arch reconstruction; however, variability persists regarding cannulation strategies. Direct innominate artery cannulation may simplify arterial access while maintaining..
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Abstract Background While minimally invasive techniques for simple septal defects have demonstrated comparable safety and efficacy to median sternotomy, clinical outcomes following minimally invasive repair of Tetralogy of Fallot (TOF)..
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Abstract Temporary mechanical circulatory support (tMCS) has evolved as a first-line treatment of cardiogenic shock refractory to medical therapy. In recent years, tMCS has been applied to bridge and precondition..
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Abstract Objectives To evaluate the feasibility of continuous bilateral lower-limb near-infrared spectroscopy (NIRS) monitoring as an adjunct to standard hourly neurovascular assessment (NVA) in patients receiving intra-aortic balloon pump (IABP)..
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Abstract Cardiac surgery-associated acute kidney injury (CS-AKI) increases short- and long-term mortality, progression to chronic kidney disease (CKD), and healthcare costs. Its pathogenesis is multifactorial—combining renal hypoperfusion, impaired oxygen delivery,..
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Abstract Objective To clarify how centrifugal blood pump-induced non-physiological shear stress affects platelet adhesion and aggregation, explaining the coexistence of thrombosis and bleeding during centrifugal pump support. Methods Blood samples..
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Abstract Background: Preoperative anaemia and perioperative transfusion are associated with adverse outcomes after cardiac surgery with cardiopulmonary bypass (CPB). Coronavirus disease 2019 (COVID-19) may induce persistent haematological and endothelial alterations...
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Abstract Background The incidence and risk factors of cardiac surgery–associated acute kidney injury (CS-AKI) are variable. We describe the incidence of severe postoperative CS-AKI (i.e., stage 2 or 3 AKI)..
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Abstract Background Perfusionists manage critical physiological parameters of cardiac surgery patients during cardiopulmonary bypass (CPB), requiring rapid, high-stakes decision-making under uncertainty. While artificial intelligence (AI) has the potential to enhance..
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Abstract Background: Dosing albumin to normalize colloid osmotic pressure is an underutilized strategy within the application of cardiopulmonary bypass. The negative sequelae of third-spacing and edema post-bypass are well known..
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Abstract Objective: To evaluate inflammatory biomarkers and lipidomic profiles in tracheal aspirates (TA) of infants with congenital heart disease (CHD), by pulmonary blood flow (Qp) high/low grouping at the time..
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Abstract Background: Hemofiltration during pediatric cardiopulmonary bypass (CPB) is essential to mitigate hemodilution, inflammatory responses, and postoperative complications. Conventional ultrafiltration (CUF) is widely practiced, but novel methods such as subzero..
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Abstract Introduction del Nido cardioplegia had not been commercially available in the United Kingdom prior to the DESTINY trial, a multi-centre individually randomised controlled trial to evaluate whether del Nido..
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Abstract Introduction: The global prevalence of morbid obesity is increasing, presenting challenges in cardiac surgery. Morbid obesity (body mass index ≥40 kg/m2) is associated with a high burden of cardiometabolic comorbidities..
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Abstract Objectives To identify a critical cardiopulmonary bypass (CPB) duration threshold predictive of a complicated postoperative course after elective cardiac surgery in the absence of technical complications and to find..
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Abstract Background: Allogenic blood product transfusion has well-documented risks and adverse outcomes. To limit perioperative transfusions for neonates and infants undergoing cardiac surgery, our institution launched a blood conservation program..
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