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Hereditary angioedema in cardiac surgery: Perioperative management considerations for a rare disease

Abstract Introduction Hereditary Angioedema is a rare disease caused by C1 esterase inhibitor deficiency leading to diffuse and potentially life-threatening oedema formation. Preventing attacks is critical, particularly for patients undergoing..

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Continuous Contactless Measurement of Blood Volume Inside Venous Reservoirs for Cardiopulmonary Bypass

Abstract During a cardiopulmonary bypass (CPB) procedure using a heart-lung machine, the volume of blood inside the venous reservoir is a crucial piece of information for the perfusionist to make..

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Poorly controlled hypertension is associated with increased coronary myogenic tone in patients undergoing cardiac surgery with cardiopulmonary bypass

Abstract Objective  and  dysregulate coronary  tone, which can be further affected by common   undergoing cardiac surgery. This study investigates differences in coronary myogenic tone and  to  before and after cardioplegia and  based on hypertension history. Methods..

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Hydromorphone mitigates cardiopulmonary bypass-induced acute lung injury by repressing pyroptosis of alveolar macrophages

Abstract Introduction  Acute lung injury (ALI) is a devastating pulmonary illness with diffuse inflammatory responses. Hydromorphone (Hyd) is an opioid agonist used for relieving moderate-to-severe pain. The present work investigated the..

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Prolonged cardiovascular pharmacological support and fluid management after cardiac surgery

Abstract Objective To identify potentially modifiable risk factors related to prolonged cardiovascular pharmacological support after weaning from cardiopulmonary bypass (CPB). Methods This is a secondary analysis of two prospective cohort..

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Point-of-Care Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra

Abstract Objectives Viscoelastic tests allow a reduction in blood product transfusion. Three modern devices are currently available (rotational  [ROTEM] sigma,  [TEG] 6S, and Quantra). No study has compared the performances of these..

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Combined Extracorporeal Lung and Kidney Support in Fluid Overload

Abstract During artificial organ support, kidney injury is multifactorial and related to the high severity of patients treated with extracorporeal membrane oxygenation (ECMO). The successful delivery of continuous renal replacement..

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Modified Ultrafiltration Should Not Be Routinely Used in Adult Cardiac Surgery

Abstract Pediatric Literature As the practice of ultrafiltration arose from pediatric cardiac surgery, much of the evidence to support MUF is from low-powered pediatric studies. Some early, single-center literature, as..

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Modified Ultrafiltration Is Beneficial for Adults Undergoing Cardiac Surgery

Abstract Hemodilution and Volume Overload The use of CPB necessitates priming of the CPB circuit, which is typically accomplished using 1-to-2 liters of a crystalloid solution. In addition, 1-to-3 liters..

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Cost-Effectiveness of Cell Salvage in Trauma Blood Transfusions

Abstract Introduction Despite the increasing amount of evidence supporting its use, cell salvage (CS) remains an underutilized resource in operative trauma care in many hospitals. We aim to evaluate the..

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Recommendations for developing effective and safe paediatric and congenital heart disease services in low-income and middle-income countries: a public health…

Abstract The global burden of paediatric and congenital heart disease (PCHD) is substantial. We propose a novel public health framework with recommendations for developing effective and safe PCHD services in low-income..

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Sounding the Alarm: What Clinicians Need to Know about Physical, Emotional and Cognitive Recovery After Venoarterial Extracorporeal Membrane Oxygenation

Abstract Objective:  We summarize the existing data on the occurrence of physical, emotional, and cognitive dysfunction associated with postintensive care syndrome (PICS) in adult survivors of venoarterial extracorporeal membrane oxygenation..

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The Use of Cardioprotective Devices and Strategies in Patients Undergoing Percutaneous Procedures and Cardiac Surgery

Abstract In the United States, about one million people are seen to visit the operating theater for cardiac surgery annually. However, nearly half of these visits result in complications such..

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How do we forecast tomorrows’ transfusion: Non-transfusional hemotherapy

Abstract Hemotherapy is the treatment of diseases by the use of blood or blood products from blood donation (by others of for oneself). It is clear that blood components transfusion..

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Supplemental fibrinogen restores thrombus formation in cardiopulmonary bypass-induced platelet dysfunction ex vivo

Abstract Background Major cardiac surgery related blood loss is associated with increased postoperative morbidity and mortality. Platelet dysfunction is believed to contribute to post-cardiopulmonary bypass (CPB)-induced microvascular bleeding. We hypothesised..

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Gene Expression of Inflammatory Cytokines in Major Organs by Extracorporeal Circulation

Abstract Background: Extracorporeal circulation (ECC) is indispensable for cardiac surgery. Despite the fact that ECC causes non-physiological damage to blood components, its pathophysiology has not been fully elucidated. In our..

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Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

Abstract Left ventricular assist device (LVAD)–induced hemodynamics are characterized by fast-moving flow with large variations in velocity, making quantitative assessments difficult with existing imaging methods. This study demonstrates the ability of..

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Contemporary practice and perception of autologous blood salvage in hepato-pancreatico-biliary operations: an international survey

Abstract Background This study aimed to assess contemporary knowledge, attitudes and behaviors around transfusion of intraoperative salvaged blood (sRBCt) during hepato-pancreatico-biliary (HPB) operations. Findings are meant to inform the design..

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The Nikaidoh Operation: An Aortic Translocation Repair

The patient is a two-and-a-half-year-old child with d-TGA/VSD/PS who underwent aortic translocation. The patient’s anatomy was typical of d-transposition with VSD and PS. Both coronaries were favorable in that they..

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PerfWeb 96 - Nov 8th

ECMO: Is It Just a Four Letter Word? (Extracorporeal Membrane Oxygenation) A review of ECMO (Extracorporeal Membrane Oxygenation) usage and outcome before, during and post COVID.  

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PerfWeb 95 - Oct 18th

Goal Directed Perfusion and The Inexorable Conflict of What The Goals Are   Discussions about the use of Goal Directed Perfusion and balancing the needs of the surgeon and the..

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PerfWeb 94

Damed If You Do, Damned If You Don't - RBC Transfusions Transfusions cary risks, anemia causes morbidities: Discussions surrounding the use of transfusions, transfusion management and when transfusions are just..

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PerfWeb 93 - August 16th

IABP for Perfusion. The Physics of Intra Aortic Balloon Pump Understanding the physics of Intra-Aortic Balloon Pumps. Learn the 8 phases of the cardiac cycle and how to accurately time..

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PerfWeb 92 - July 19

RAPP (Retrograde Autologous Pump Prime) Emily Foreman, CCP reviews her peer reviewed publication on RAPP as a transfusion management procedure.         

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Manual ECMO - Heart Team Chile

Profesionales del hospital San Juan de Dios y la Clínica red Salud Santiago, con mas de 20 años de experiencia, han realizado este manual ECMO disponible para todo el mundo...

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Impact of Nosocomial Infection on in-Hospital Mortality Rate in Adult Patients Under Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery

Abstract Objective: There was no consensus on the impact of nosocomial infection on In-hospital mortality rate in patients receiving ECMO. This study aimed to investigate the impact of nosocomial infection (NI)..

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It All Circles Back to Cerebral Autoregulation: Understanding the Risk of Hypocapnia and Arterial Hypertension when initialing Pediatric Extracorporeal Membrane…

Abstract Clinicians caring for children with cardiopulmonary failure using extracorporeal membrane oxygenation (ECMO) are refining bedside clinical practices by focusing on minimizing morbidity associated with neurologic complications. Neurologic complications are the main drivers of survival..

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On-Support and Post-Weaning Mortality in Post-Cardiotomy Extracorporeal Membrane Oxygenation

Abstract BACKGROUND Post-cardiotomy veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is characterized by discrepancies between weaning and survival-to-discharge rates. This study analyzes the differences between post-cardiotomy V-A ECMO patients who survived,..

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The Disconnect Between Extracorporeal Circulation and the Microcirculation: A Review

Abstract Extracorporeal circulation (ECC) procedures, such as cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO), take over the function of one or more organs, providing clinicians time to treat underlying pathophysiological..

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