The oxygen dissociation curve is a critical concept in understanding how oxygen is transported in the blood and delivered to tissues. In anaesthesia, inhaled anaesthetic agents are the fundamental tools for managing anaesthesia during surgical procedures. These agents, such as desflurane, isoflurane, and sevoflurane, are known for effects on the central nervous system and cardiovascular stability. However, their impact on haemoglobin’s oxygen-binding capacity, represented by shifts in the oxygen dissociation curve, can have significant effects on patient care. This discussion explores the interactions between inhaled anaesthetic agents and the oxygen dissociation curve, focusing on how these drugs alter haemoglobin’s affinity for oxygen and the potential clinical consequences of such interactions. Clinical implications: oxygen dissociation curve shifts are crucial in patient management, especially in populations with compromised pulmonary function or those undergoing extensive surgeries. Anaesthesia providers must consider these effects when optimising oxygen delivery and anaesthetic depth.