This guideline discusses nutritional support for neonatal and pediatric patients requiring extracorporeal membrane oxygenation (ECMO) support. Data for nutrient delivery during ECMO support and its impact on outcomes are scarce. Hence, practice may be variable and evidence-based guidelines are limited. Provision of nutrition during ECMO may be impeded by concerns of patient instability, volume restriction, and possible enteral nutrition (EN) intolerance due to splanchnic ischemia. These guidelines include evidence-based, where available, or consensus-based recommendations for best practices on five domains of nutritional delivery in the neonatal and pediatric ECMO patient. A summary table of pertinent literature is included.