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Rethinking Blood Pump Safety: The Case for Nonocclusive Pressure-Regulated Pumps

In cardiopulmonary bypass (CPB), roller and centrifugal pumps have been the mainstays for decades, each with unique benefits and challenges. However, these traditional blood pumps come with inherent pressure-related risks..

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Biocompatible and Miniaturized Cardiopulmonary Bypass Circuits: Shaping the Future of…

Introduction Cardiopulmonary bypass (CPB) is fundamental to modern cardiac surgery, allowing surgeons to perform complex procedures on a still and bloodless heart. However, traditional CPB systems are associated with complications..

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Substrate Enhancement in Cardioplegia: Current Concepts and Future Directions

Introduction Myocardial protection during cardiac surgery is a critical determinant of patient outcomes. Traditional cardioplegia techniques primarily aim to arrest the heart, reduce metabolic demand, and preserve myocardial viability (Buckberg,..

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The Air-Blood Interface During Cardiopulmonary Bypass: Mechanisms and Clinical Implications

Introduction: Cardiopulmonary bypass, a cornerstone of modern cardiac surgery, temporarily diverts blood away from the heart and lungs, allowing for surgical intervention in a controlled environment. During CPB, blood is..

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Basic Goals of Myocardial Protection During Cardiopulmonary Bypass (CPB)

Introduction Cardiopulmonary bypass (CPB) is essential for modern cardiac surgery, allowing complex repairs and reconstructions by diverting blood away from the heart and lungs. However, during this process, the heart's..

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Inflammatory Responses During Cardiopulmonary Bypass: Mechanisms, Mediators, and Management Strategies

Abstract: Cardiopulmonary bypass (CPB) induces a multifactorial systemic inflammatory response that significantly contributes to postoperative complications such as acute lung injury, renal dysfunction, and increased morbidity. This response is initiated..

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Perfusion Physiology: The Interplay of Flow, Pressure, Hematocrit, and Oxygen…

Introduction Cardiopulmonary bypass (CPB) has revolutionized cardiac surgery by temporarily taking over the function of the heart and lungs during complex procedures. Central to this technique is the management of..

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Optimizing Filtration in Cardiopulmonary Bypass: A Comprehensive Overview

Introduction Cardiopulmonary bypass (CPB) plays a pivotal role in modern cardiac surgery by temporarily assuming the functions of the heart and lungs during complex procedures. However, despite its life-saving capabilities,..

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Aseptic Techniques in the Setup of Cardiopulmonary Bypass: Ensuring Safety…

Introduction: Cardiac surgery is among the most delicate and high-risk procedures in modern medicine, and the use of cardiopulmonary bypass (CPB) is central to its success. In this complex setting,..

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Priming Techniques in Cardiopulmonary Bypass: An Overview.

Introduction Cardiopulmonary bypass (CPB) is a cornerstone of modern cardiac surgery, facilitating complex intracardiac procedures by temporarily assuming the function of the heart and lungs. One of the most critical..

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