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The application of autopsy and explanted heart samples in scientific research

Abstract Cardiovascular disease, which accounts for nearly one-third of deaths globally, is a great threat to human life and health. To improve global health and advance the progression of cardiovascular..

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Intraoperative Diagnosis of Bronchovenous Fistula During Lung Transplantation Using Transesophageal Echocardiography

Abstract Bronchovenous  (BVF) is a rare complication and can cause arterial gas embolism in vital organs, including the heart and the brain, resulting in a high mortality rate. A 51-year-old man..

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The Use of Hemoglobin-Based Oxygen Carriers in Ex Vivo Machine Perfusion of Donor Organs for Transplantation

Abstract There has been significant progress in the development of ex vivo machine perfusion for the nonischemic preservation of donor organs. However, several complications remain, including the logistics of using human blood..

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Histidine–tryptophan–ketoglutarate solution versus multidose cardioplegia for myocardial protection in cardiac surgeries: a systematic review and meta-analysis

Abstract Background Surgical procedures in the heart requires protection of the heart from ischemia–reperfusion injury. Cardioplegia is the primary myocardial protective method in use. Histidine–tryptophan–ketoglutarate (HTK) solution is an intracellular..

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Ex Vivo Lung Perfusion: A Review of Current and Future Application in Lung Transplantation

Abstract The number of waitlisted lung transplant candidates exceeds the availability of donor organs. Barriers to utilization of donor lungs include suboptimal lung allograft function, long ischemic times due to..

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Extracorporeal interval support for organ retrieval delivery regional experience with sharing equipe, equipment & expertise to increase conventionally defined as…

Abstract Donation after circulatory death (DCD) programs are expanding in Europe, in the attempt to expand donors pool. Even in controlled DCD donors, however, a protracted warm ischemia time occurring..

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Temporary Left Ventricular Support Device as a Bridge to Heart-Liver or Heart-Kidney Transplant: Pushing the Boundaries of Temporary Support

Abstract In patients with severe cardiogenic shock, temporary mechanical circulatory support has become a viable strategy to bridge patients to heart transplantation. However, end-stage heart failure is often associated with progressive organ..

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Rescue venovenous extracorporeal membrane oxygenation for the deterioration of acute respiratory distress syndrome in pediatric liver transplantation

Abstract Background Twenty percent of pediatric patients with BA develop ACLF with increased mortality while awaiting LT. Respiratory complications are common in pediatric ACLF and are associated with increased morbidity..

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PATHOBIOLOGY OF MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY

Abstract This review presents an integrated approach to the analysis of myocardial ischemia and reperfusion injury and the modulating influence of myocardial conditioning during the evolution of acute myocardial infarction..

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Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices

Abstract Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become an essential method for assaying hemostatic competence in liver transplantation, cardiac surgery, and most recently, trauma surgery..

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Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly

Abstract Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect..

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Weaning from Veno Arterial Extracorporeal Membrane Oxygenation

The ELSO Interim Guidelines for venoarterial extracorporeal membrane oxygenation (VA ECMO) is timely. I would like to raise a few points on weaning recommendations. First, the parameters detailed in Figure 11..

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The Use of Extracorporeal Support to Rescue Patients With Acute Respiratory Distress Syndrome Following Thoracic Surgery

Abstract Postoperative acute respiratory distress syndrome (ARDS) following a general thoracic procedure is associated with high morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) offers an alternate means of cardiopulmonary support in the..

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Successful Heart Transplantation Recovered From a Brain-Dead Donor on Veno-Arterial Extracorporeal Membrane Oxygenation Support

Abstract We describe the successful transplantation of a brain-dead donor supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO) after cardiac arrest secondary to pulmonary embolism. The donor was a 50-year-old female..

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Trends and Outcomes of Left Ventricular Assist Device Therapy: JACC Focus Seminar

Abstract As the prevalence of advanced heart failure continues to rise, treatment strategies for select patients include heart transplantation or durable left ventricular assist device (LVAD) support, both of which..

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Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant

Abstract Importance  Ischemic cold storage (ICS) of livers for transplant is associated with serious posttransplant complications and underuse of liver allografts. Objective  To determine whether portable normothermic machine perfusion preservation of livers..

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Ambulatory home wearable lung: progress and future directions

Abstract Extracorporeal life support (ECLS) was first implemented as an extension of cardiopulmonary bypass technology. The early use of ECLS in patients with acute respiratory distress syndrome (ARDS) was discouraging,..

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Intraoperative support during lung transplantation

Abstract The role of intraoperative mechanical support during lung transplantation (LTx) is essential to provide a safe hemodynamic and ventilatory status during critical intraoperative events. This hemodynamic and ventilatory stability..

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Controlled temperatures in cold preservation provides safe heart transplantation results

Abstract Background We aimed to investigate the short-term outcomes of heart transplant patients who underwent SherpaPak™ donor organ preservation. Method We prospectively collected the data of patients who underwent heart..

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Current Status and Future Perspectives on Machine Perfusion: A Treatment Platform to Restore and Regenerate Injured Lungs Using Cell and…

Abstract Since its advent in the 1990′s, ex vivo lung perfusion (EVLP) has been studied and implemented as a tool to evaluate the quality of a donor organ prior to..

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A patient with pulmonary hypertension waiting for donor lungs during the pandemic: 194 days on extracorporeal life support including 143…

Abstract Patients with pulmonary hypertension and end-stage lung disease are fraught with high mortality while on a waiting list for lung transplant. With sometimes rapid deterioration they may require veno-arterial..

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Pulmonary Transplant After More Than 1 Year of Continuous Ambulatory Extracorporeal Support

Abstract While extracorporeal support of patients awaiting pulmonary transplantation is now well-established, extracorporeal membrane oxygenation (ECMO) remains a nondurable technology deployed for short-term support or recovery in patients with progressive..

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PHYSIOLOGIC EFFECTS OF CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICES

Abstract Background Within the past ten years, continuous-flow Left Ventricular Assist Devices (LVADS) have replaced pulsatile-flow LVADs as the standard of care for both destination therapy and bridging patients to..

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Early implementation of renal replacement therapy after lung transplantation does not impair long-term kidney function in patients with idiopathic pulmonary…

Abstract Objectives In patients with idiopathic pulmonary arterial hypertension, cardiac function can be impaired in the early  after  because the chronically untrained  is prone to fail. Thus, restrictive fluid management is pivotal to..

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Central, peripheral ECMO or CPB? Comparsion between circulatory support methods used during lung transplantation

Abstract Background Chronic obstructive pulmonary disease, cystic fibrosis and usual interstitial pneumonia are three most common indications for lung transplantation (LuTx) in Poland. As a result of irreversible destruction of..

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Safety of intra-operative blood salvage during liver transplantation in patients with hepatocellular carcinoma, a propensity score-matched survival analysis

Abstract Intra-operative blood salvage (IBS) reduces the use of allogeneic blood transfusion. However, safety of IBS during liver transplantation (LT) for hepatocellular carcinoma (HCC) is questioned due to fear for..

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Integration Process With a Donated Heart

Abstract Background  In the posttransplant period, recipients face a complex phenomenon called the new heart, which is a symbol of physical and emotional life. They use different methods to get..

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Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Abstract Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements..

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Early experience with donation after circulatory death heart transplantation using normothermic regional perfusion in the United States

Abstract Objective This pilot study sought to evaluate the feasibility of our donation after circulatory death (DCD) heart transplantation protocol using cardiopulmonary bypass (CPB) for normothermic regional reperfusion (NRP). Methods..

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Central, peripheral ECMO or CPB? Comparison between circulatory support methods used during lung transplantation

Abstract Background Chronic obstructive pulmonary disease, cystic fibrosis and usual interstitial pneumonia are three most common indications for lung transplantation (LuTx) in Poland. As a result of irreversible destruction of..

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