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Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial

Abstract Background The Organ Care System is the only clinical platform for ex-vivo perfusion of human donor hearts. The system preserves the donor heart in a warm beating state during..

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Timing and Strategy for Weaning From Venoarterial ECMO are Complex Issues

Abstract Objective Weaning from venoarterial extracorporeal membrane oxygenation (VA ECMO) usually is performed without clear guidelines; yet, patients still die after removal of extracorporeal circulation because of inadequate heart or..

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Rescue of Discarded Grafts for Liver Transplantation by Ex Vivo Subnormothermic and Normothermic Oxygenated Machine Perfusion: First Experience in Spain

Abstract Background   (MP) has been reported as a possibly method to rescue discarded organs. The main aim of this study was to report an initial experience in Spain using MP..

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Development of a practical prediction score for chronic kidney disease after cardiac surgery

Abstract Background Chronic kidney disease (CKD) is a frequent and serious complication of cardiac surgery. This study was designed to establish a scoring system, calculated in the immediate postoperative period,..

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Feasibility of autologous intraoperative blood collection and retransfusion in small children with complex congenital heart defects undergoing cardiopulmonary bypass

Abstract Introduction Allogeneic blood product transfusion is common in pediatric patients undergoing cardiopulmonary bypass although it is associated with an increased risk for adverse events. Furthermore, numerous donor exposures may..

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Designing an Extracorporeal Cardiopulmonary Resuscitation Protocol: It Is Time to Address Quality

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) refers to the use of temporary mechanical support as an adjunct to standard CPR in patients with cardiovascular collapse. Although it is a relatively recent..

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Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery

Abstract AIM To investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery. METHODS In this prospective study, patients undergoing cardiac surgery received a..

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First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion

Abstract Background Donation after circulatory death (DCD) can increase the pool of available organs for transplantation. This pilot study evaluates the implementation of a controlled DCD (cDCD) protocol using normothermic..

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Predictors of Poor Outcomes in Pediatric Venoarterial Extracorporeal Membrane Oxygenation

Abstract Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides respiratory and hemodynamic support to pediatric patients in severe cardiac failure. We aim to identify risk factors associated with poorer outcomes in..

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Position paper for the organization of ECMO programs for cardiac failure in adults

Abstract Extracorporeal membrane oxygenation (ECMO) has been used increasingly for both respiratory and cardiac failure in adult patients. Indications for ECMO use in cardiac failure include severe refractory cardiogenic shock,..

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Open Cardiac Surgery without Blood and Blood Products Transplantation

ABSTRACT Background: Blood transfusions are the most common type of tissue and organ transplantation. Perioperative and postoperative transfusions may cause morbidity and mortality and transfusion should based on only hematocrit values..

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Continuous Monitoring of Cerebral Autoregulation in Children Supported by Extracorporeal Membrane Oxygenation: A Pilot Study

The use of extracorporeal membrane oxygenation has had a positive impact on the outcomes after lung transplantation. Extracorporeal membrane oxygenation has a role in all phases of lung transplantation—preoperative, intraoperative,..

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The Great Ormond Street Hospital Immunoadsorption Method for ABO-Incompatible Heart Transplantation: a Practical Technique

Traditionally, ABO-incompatible heart transplantation was accomplished using a plasma exchange technique to remove recipient plasma containing donor-incompatible anti-A/B isohaemagglutinins. However, this technique exposed patients to large volumes of allogeneic blood..

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Artificial Lungs–Where Are We Going with The Lung Replacement Therapy?

Abstract Lung transplantation may be a final destination therapy in lung failure, but limited donor organ availability creates a need for alternative management, including artificial lung technology. This invited review..

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