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Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass: A Systematic Review and Meta-analysis

Abstract BACKGROUND:  Bleeding is one of the commonest complications affecting children undergoing cardiac surgery on cardiopulmonary bypass. Antifibrinolytic drugs are part of a multifaceted approach aimed at reducing bleeding, though..

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Residual Lesion Diagnostics in Pediatric Postcardiotomy Extracorporeal Membrane Oxygenation and Its Outcomes

Abstract Background: To assess the impact of diagnostic procedures in identifying residual lesions during extracorporeal membrane oxygenation (ECMO) on survival after pediatric cardiac surgery. Methods: Between January 2012 and December..

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Strategies to Prevent Acute Kidney Injury after Pediatric Cardiac Surgery

Abstract Background and objectives AKI is a common complication after pediatric cardiac surgery and has been associated with higher morbidity and mortality. We aimed to compare the efficacy of available pharmacologic..

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Bi-Caval Dual Lumen Catheter for Pediatric Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation

Abstract An 11-year-old female patient was admitted to a pediatric intensive care unit for the treatment of acute respiratory distress syndrome (ARDS). She had received peripheral blood stem cell transplantation..

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Interrelations of Intraoperative Changes in Cerebral Tissue Oxygen Saturation with Brain Volumes and Neurodevelopment Outcome After the Comprehensive Stage II…

Abstract Objectives The monitoring of cerebral tissue oxygen saturation by near-infrared spectroscopy (ScerebO2) is used widely in pediatric cardiac anesthesia. However, little information is available on the effects of changes..

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EuroELSO Webinar: Anticoagulation monitoring on ECMO in neonates and children: moving target

  EuroELSO Webinar on 30 March 2021 Topic: Anticoagulation monitoring on ECMO in neonates and children: moving target - anti Xa over ACT & APTT.   Introduction, moderation & closing..

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Risk Factors of Venoarterial Extracorporeal Membrane Oxygenation–Related Intracranial Hemorrhage in Children with Congenital Heart Disease

Abstract To analyze the risk factors for intracranial hemorrhage (ICH) in congenital heart disease (CHD) patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO). We performed a retrospective analysis of VA ECMO patients..

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Routine Neuroimaging. Understanding Brain Injury in Pediatric Extracorporeal Membrane Oxygenation

Abstract Objectives:  This project aims to describe brain injuries on routine neuroimaging in a large single-center neonatal and pediatric cohort supported by extracorporeal membrane oxygenation. The study also aims to..

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Repeat Extracorporeal Membrane Oxygenation Support Is Appropriate in Selected Children With Cardiac Disease: An Extracorporeal Life Support Organization Study

Abstract Objective: Children requiring multiple consecutive extracorporeal membrane oxygenation (ECMO) runs likely have ongoing cardiac pathology (eg, residual lesions, myocardial dysfunction) and are exposed to increased complications and end-organ failure...

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Early biochemical markers in the assessment of acute kidney injury in children after cardiac surgery

Abstract Our aim was to evaluate biochemical markers in plasma (NGAL, CysC) and urine (NGAL, KIM-1) in children's early onset of acute kidney injury after congenital heart defect surgery using..

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Repeat Extracorporeal Membrane Oxygenation Support Is Appropriate in Selected Children With Cardiac Disease: An Extracorporeal Life Support Organization Study

Abstract Objective: Children requiring multiple consecutive extracorporeal membrane oxygenation (ECMO) runs likely have ongoing cardiac pathology (eg, residual lesions, myocardial dysfunction) and are exposed to increased complications and end-organ failure...

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Use of CytoSorb in the treatment of a pediatric patient with acute hepatitis C complicated by HIV, toxic hepatitis, and…

The case reports on a 17-year-old boy (weight 70 kg) transferred to the Children Infections Research Center intensive care unit (ICU) with severe jaundice and in a poor general condition..

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International survey of neuromonitoring and neurodevelopmental outcome in children and adults supported on extracorporeal membrane oxygenation in Europe

Abstract Background: Adverse neurological events during extracorporeal membrane oxygenation (ECMO) are common and may be associated with devastating consequences. Close monitoring, early identification and prompt intervention can mitigate early and..

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Biomarkers for Adverse Lung Injury Following Pediatric Cardiopulmonary Bypass

Abstract OBJECTIVES: Cardiopulmonary bypass triggers systemic inflammation, resulting in lung injury, and frequently leads to prolonged mechanical ventilation. Biomarkers of systemic inflammation are required to predict the risk of such..

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Methylprednisolone Plasma Concentrations During Cardiac Surgery With Cardiopulmonary Bypass in Pediatric Patients

Abstract Introduction: To our knowledge, methylprednisolone pharmacokinetics and plasma concentrations have not been comprehensively investigated in children with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass. It is unknown whether..

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Timing of congenital cardiac surgery in children who turned COVID-19 positive

Abstract We report a series of four patients with CHD who tested positive for COVID-19, got treated, and underwent cardiac surgery in the same sitting. All had an uneventful perioperative..

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A Communication Guide for Pediatric Extracorporeal Membrane Oxygenation

Abstract Decision-making surrounding extracorporeal membrane oxygenation initiation and decannulation has become a key challenge in critical care. Nuanced communication skills and transparent discussions about prognosis are imperative during this lifesaving,..

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Safety and utility of modified ultrafiltration in pediatric cardiac surgery

Abstract Introduction: Modified ultrafiltration (MUF) is employed at the termination of cardiopulmonary bypass (CPB) in pediatric and neonatal patients undergoing congenital heart surgery to reduce the accumulation of total body..

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Blood pressure variability during pediatric cardiac surgery is associated with acute kidney injury

Abstract Background Blood pressure variability (BPV), defined as the degree of variation between discrete blood pressure readings, is associated with poor outcomes in acute care settings. Acute kidney injury (AKI)..

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Use of CytoSorb in case of operative extraction of the massive right atrium thrombus associated with Hickman catheter in Non-Hodgkin…

This case reports on a 16-year-old male patient (weight 56 kg), who was admitted from the hematology-oncology ward to the Pediatric Intensive Care Unit (PICU) after a clinical deterioration with..

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The Albumin-to-Fibrinogen Ratio Independently Predicts Acute Kidney Injury in Infants With Ventricular Septal Defect Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Abstract Background: Acute kidney injury (AKI) is a common and serious complication faced by children following ventricular septal defect (VSD) surgery with cardiopulmonary bypass (CPB). The objective of this study was..

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Centrifugal and Roller Pumps in Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) is an invaluable means of supporting critically ill children with refractory respiratory or cardiac failure. Controversy remains; however, whether roller or centrifugal pumps are superior,..

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Priming solution for neonatal and pediatric cardiopulmonary bypass

Abstract The Priming volume of the oxygenators has been reduced by 75% during the last two decades and it is now possible to go safely on bypass with a priming..

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Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital…

Abstract Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was..

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C-reactive protein and procalcitonin after congenital heart surgery utilizing cardiopulmonary bypass: When should we be worried?

Abstract Introduction To assess the efficacy of C-reactive protein (CRP) and procalcitonin (PCT) at identifying infection in children after congenital heart surgery (CHS) with cardiopulmonary bypass (CPB). Materials and Methods..

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Impact on Renal Function and Hospital Outcomes of an Individualized Management of Cardiopulmonary Bypass in Congenital Heart Surgery: A Pilot…

Abstract During cardiopulmonary bypass (CPB), high flows can allow an adequate perfusion to kidneys, but, on the other hand, they could cause emboli production, increased vascular pressure, and a more..

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Similar frequency of atrial perforation between atrial and bicaval dual lumen veno-venous ECMO cannulas in a pediatric population

Abstract Purpose: Complications associated with use of dual-lumen venovenous extracorporeal membrane oxygenation (VV-ECMO) cannulas are of concern in pediatric patients. While the risk of atrial perforation is believed to be..

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Cefazolin prophylaxis in children undergoing cardiac surgery with the use of cardiopulmonary bypass—is the dosing correct?

Abstract OBJECTIVES To determine the recommended concentrations of cefazolin to be used for antibiotic prophylaxis during paediatric cardiac surgery with extracorporeal circulation (ECC). METHODS Twenty paediatric patients undergoing cardiac surgery..

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Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass

Abstract Objectives:  To describe blood component usage in transfused children with congenital heart disease undergoing cardiopulmonary bypass surgery across perioperative settings and diagnostic categories. Design:  Datasets from U.S. hospitals participating..

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The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg

Abstract Objective: This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under..

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