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Preparation of a cardiopulmonary bypass priming solution for infants and neonates – effect of pre-bypass ultrafiltration on heparinization

Abstract Introduction Heparin is usually added to infant cardiopulmonary bypass circuit primes. Ultrafiltration is often used to minimise prime volume before commencing bypass. The extent of heparin removal from bypass..

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A scoping review: Point-of-care ultrasound (POCUS) use in paediatric ECMO

Abstract Objective This scoping review aimed to examine current literature on the use of point-of-care ultrasound (POCUS) in paediatric patients supported by extracorporeal membrane oxygenation (ECMO). It assessed existing evidence,..

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Peri-operative Immunoglobulin Dynamics and Infection Risk in Infants Undergoing Congenital Heart Surgery: A Prospective Observational Cohort

Abstract Background:  Infants with congenital heart disease (CHD) frequently undergo surgery during their first year of life. Infants undergoing CHD surgery experience systemic inflammation and haemodilution that can deplete circulating..

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Tetralogy of Fallot With Pulmonary Atresia and the Therapeutic Role ( Scientific Explanation)

Scientific Explanation of Tetralogy of Fallot With Pulmonary Atresia and the Therapeutic Role of Dr. Sam Zeraatian-Nejad Davani 1. Introduction to the Disease: Tetralogy of Fallot (TOF) Tetralogy of Fallot..

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Quality indicators in pediatric cardiopulmonary bypass: Current perspectives and future directions

Abstract Introduction Cardiopulmonary bypass (CPB) plays a central role in pediatric cardiac surgery, yet standardized quality indicators (QIs) specific to pediatric practice remain underutilized across institutions. Methods A comprehensive review..

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Predictors of postoperative bleeding in pediatric cardiac surgery under cardiopulmonary bypass: a comparative study of thromboelastography parameters and central laboratory…

Abstract Purpose Postoperative bleeding is a major concern in pediatric cardiac surgery under cardiopulmonary bypass (CPB). The comparative utility of viscoelastic testing and central laboratory assays for predicting bleeding risk..

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The impact of remote ischemic preconditioning on postoperative outcomes in pediatric cardiac surgery: an updated systematic review and meta-analysis

Abstract Remote ischemic preconditioning (RIPreC) has been regarded as a promising strategy to reduce ischemia-reperfusion injury to the heart and other organs caused by cardiopulmonary bypass. While RIPreC has demonstrated..

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Neuromonitoring and neuroprotection during neonatal aortic arch surgery: A United Kingdom and Ireland survey

Abstract Introduction Neonatal aortic arch surgery is associated with neurological morbidity of varying severity which is detected and potentially limited through neuroprotective strategies. We conducted a survey of healthcare professionals..

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Routine administration of enoximone in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass to prevent and treat early low…

Abstract Low cardiac output syndrome (LCOS) is defined by an insufficient cardiac output to meet metabolic demands, leading to tissue hypoperfusion and potential organ dysfunction. Although it affects up to 42%..

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Thrombus formation in neonates and early infants undergoing congenital heart surgery

Abstract Objective This study evaluated thrombus formation and its impact on outcomes in neonates and early infants undergoing congenital heart surgery. Methods Neonates and early infants (≤90 days) undergoing congenital..

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Congenital diaphragmatic hernia: Exclusion criteria for repair or ECMO?

Abstract Background Mortality in congenital diaphragmatic hernia (CDH) approximates 30 %. Both severe lung hypoplasia and other anomalies contribute to demise regardless of repair and/or extracorporeal membrane oxygenation (ECMO). We..

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Entropy-guided sevoflurane administration during cardiopulmonary bypass surgery in the paediatric population

Abstract Background Maintaining optimal anesthetic depth during cardiopulmonary bypass (CPB) in pediatric patients is challenging due to altered physiology and unreliable conventional monitoring. Entropy, a processed electroencephalogram metric, offers a..

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Cytokine profile of Post–cardiopulmonary bypass in children

Abstract Background Open cardiac surgery involving cardiopulmonary bypass (CPB) triggers a systemic inflammatory response that significantly affects clinical outcomes. However, the dynamics and specific roles of cytokine release after CPB..

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Health-Related Quality of Life in Children 4-5 Years After Open Heart Surgery in Early Infancy

Abstract Background Health-related  (HRQL) is an important outcome measure in . We aimed to determine HRQL of children who underwent complex cardiac surgery at age ≤6 weeks with follow-up at age 4-5..

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Development and External Validation of a Novel In-hospital Mortality Model after Pediatric Congenital Heart Surgery: A Multicenter Retrospective Cohort Study

Abstract Background: The applicability of four major traditional in-hospital mortality models in the Chinese setting is unclear due to disease spectrum and population heterogeneity. This study aimed to test the..

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A randomised clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: five-year and ten-year follow-up for neurodevelopmental outcomes…

Abstract Objective:This study aimed to evaluate school-age neurodevelopmental outcomes among children with single ventricle heart disease who underwent neonatal Norwood operation with regional cerebral perfusion compared to deep hypothermic circulatory..

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Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery

Abstract Allogeneic red blood cells (RBCs) are commonly used for cardiopulmonary bypass (CPB) circuit priming in congenital heart surgery. While convection-based pre-bypass ultrafiltration (PBUF) corrects acid–base, electrolyte, and metabolite imbalances,..

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Variation in Techniques of Selective Antegrade Cerebral Perfusion in Neonates Undergoing Aortic Arch Reconstruction: A Comprehensive Review

Abstract Background Despite the widespread adoption of selective antegrade cerebral perfusion (SACP) for neonatal aortic arch reconstruction, significant variability in techniques persists across institutions, thus reflecting limited supporting data and..

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Developing a Protocol for Therapeutic Plasma Exchange in Tandem With Continuous Renal Replacement Therapy (CRRT) and ExtraCorporeal Membrane Oxygenation (ECMO)…

Abstract Therapeutic plasma exchange (TPE) in pediatric patients presents many challenges, including management of a large extracorporeal volume (ECV) and calcium replacement for patients who may not be able to..

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A Canadian Experience With a Percutaneous Microaxial Ventricular Assist Device in Children With Cardiogenic Shock

Abstract Background The experience of a percutaneous microaxial (Impella)  in children with  is limited. The primary objective of this study was to review our institutional clinical outcomes of Impella use in children..

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Elementary school performance of children with congenital heart disease: a Danish nationwide cohort study

Abstract Aims Academic achievement of children with congenital heart disease (CHD) has not been comprehensively studied across the entire CHD severity spectrum. Methods and results Through nationwide registries, we identified..

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Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis

Abstract Congenital diaphragmatic hernia (CDH) is a rare and severe malformation that can lead to life-threatening postnatal physiological challenges which may require lifesaving extracorporeal membrane oxygenation (ECMO) support, sometimes more..

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Ice Water Drowning Survival After 147-Minute Submersion and 7 °C Hypothermic Circulatory Arrest

Abstract Background Young patients may survive accidental deep hypothermia with prolonged asystolic circulatory arrest because of protective effects of cold. Case Summary An 8-year-old boy fell through pond ice and..

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Delayed Sternal Closure Following Complex Cardiac Surgery in Neonates

Abstract Background Delayed sternal closure (DSC) is a well-established management strategy following complex congenital cardiac surgery that is used to mitigate postoperative hemodynamic and respiratory instability. It is mostly used..

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A Landscape Analysis of Pediatric and Congenital Heart Disease Services in Africa

Abstract Background There is geographic disparity in the provision of Pediatric and Congenital Heart Disease (PCHD) services; Africa accounts for only 1% of global cardiothoracic surgical capacity. Methods We conducted..

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Prediction of acute lung injury/acute respiratory distress syndrome after cardiopulmonary bypass in infants by monitoring femoral oxygen saturation

Abstract To investigate the feasibility of regional oxygen saturation (rSO2) monitoring for preventing acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) caused by cardiopulmonary bypass (CPB) in infants undergoing ventricular..

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How I Do It: Donation After Circulatory Death With Normothermic Regional Perfusion in Small Babies

Abstract Background: The gold standard for treatment of patients with end-stage heart failure remains . Time spent on the active waiting list, notably for  patients, contributes to alarmingly high mortality. Donation after..

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Description and Management of Cardiac Arrests in Congenital Cardiac Patients Undergoing Cardiac Surgery, Cardiac Catheterization, and Cardiac Imaging

Abstract Objective To describe cardiac arrest during anesthesia care provided by a pediatric cardiac anesthesiologist in patients with congenital heart disease and identify predictors of outcome. Design Retrospective chart review...

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“When I walk away and wonder, did I make the best decision?”: A decisional needs assessment among providers involved in…

Abstract Purpose Extracorporeal cardiopulmonary resuscitation (ECPR) is an advanced resuscitation therapy for cardiopulmonary arrest refractory to standard CPR. ECPR treatment recommendations are not supported by strong evidence, and institutional criteria..

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Inflammatory Markers During Extracorporeal Membrane Oxygenation in Neonates With Congenital Diaphragmatic Hernia

Abstract This study aimed to assess whether the proinflammatory markers procalcitonin (PCT), C-reactive protein (CRP), or interleukin 6 (IL-6) are associated with mortality in neonates with congenital diaphragmatic hernia (CDH)..

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