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Clinical and Hematological Outcomes of Aminocaproic Acid Use During Pediatric Cardiac ECMO

Abstract Donor shortage is a major limitation in organ transplantation. Several studies have reported that extracorporeal membrane oxygenation (ECMO)-assisted organ donation can be successfully completed without inducing warm ischemia in..

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Extracorporeal membrane oxygenation in non‑intubated immunocompromised patients

Abstract Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has become an integral part in the rescue therapy of severe acute respiratory distress syndrome (ARDS) and may be lifesaving in patients with..

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Does Targeted Temperature Management Improve Neurological Outcome in Extracorporeal Cardiopulmonary Resuscitation (ECPR)?

Abstract Purpose: Targeted temperature management (TTM) is a standard of care in patients after cardiac arrest for neuroprotection. Currently, the effectiveness and efficacy of TTM after extracorporeal cardiopulmonary resuscitation (ECPR)..

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Patients' exposure to PVC plasticizers from ECMO circuits

Abstract Background: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but..

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Is Extracorporeal Membrane Oxygenation the Standard Care for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

Abstract Background  (ARDS) is a type of  syndrome characterised by severe respiratory distress and stubborn . Patients with ARDS have a prolonged hospital stay and high mortality rate. Over long-term follow-up, ARDS..

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Pump flow setting and assessment of unloading in clinical practice

Abstract The rationale for mechanical circulatory support (MCS) in cardiogenic shock is to restore cardiac output in selected patients when critically low or in case of refractory cardiac arrest. Furthermore,..

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ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables

Abstract Background and Objective Simulation in  may help clinicians understand the important events occurring during  and . During the COVID-19 pandemic, a significant number of patients have required hospital admission to tertiary referral..

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Successful Heart Transplantation Recovered From a Brain-Dead Donor on Veno-Arterial Extracorporeal Membrane Oxygenation Support

Abstract We describe the successful transplantation of a brain-dead donor supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO) after cardiac arrest secondary to pulmonary embolism. The donor was a 50-year-old female..

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Low vs standardized dose anticoagulation regimens for extracorporeal membrane oxygenation: A meta-analysis

Abstract Background To compare the safety and efficacy of low-dose anticoagulation (LA) with that of standardized dose anticoagulation (SA) for patients supported with extracorporeal membrane oxygenation (ECMO). Methods PubMed, MEDLINE,..

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Physiological Basis of Extracorporeal Membrane Oxygenation and Extracorporeal Carbon Dioxide Removal in Respiratory Failure

Abstract Extracorporeal life support (ECLS) for severe respiratory failure has seen an exponential growth in recent years. Extracorporeal membrane oxygenation (ECMO) and extracorporeal CO2 removal (ECCO2R) represent two modalities that can..

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Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: How Do We Expand Capacity in the COVID-19 Era?

Abstract Despite advances in medical technology, the mortality rate for severe acute respiratory distress syndrome (ARDS) remains high at around 40% []. In recent years, multiple studies, systematic reviews, and..

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Bedside angiography of distal perfusion catheter for veno-arterial extracorporeal membrane oxygenation

Abstract Background: The aim of this study was to evaluate the ipsilateral lower extremity (ILE) outcomes of patients who underwent bedside angiography via the distal perfusion catheter while on femoral..

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Axial flow ventricular assist devices in cardiogenic shock complicating acute myocardial infarction

Abstract Cardiogenic shock (CS) remains the leading cause of death in patients hospitalised with acute myocardial infarction with mortality as high as 40%–50% prior to hospital discharge. The failure of..

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Extubate Before Venovenous Extracorporeal Membranous Oxygenation Decannulation or Decannulate While Remaining on the Ventilator? The EuroELSO 2019 Weaning Survey

Abstract Patients who receive venovenous extracorporeal membrane oxygenation (VV ECMO) support upon failure of invasive mechanical ventilation (IMV) and other adjuncts, including low tidal volume, prone positioning, adjusted positive end-expiratory pressure, and..

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Basics of extra corporeal membrane oxygenation: a pediatric intensivist’s perspective

Abstract Extra Corporeal membrane oxygenation (ECMO) is one of the most advanced forms of life support therapy in the Intensive Care Unit. It relies on the principle where an external..

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The Safe Addition of Nitric Oxide into the Sweep Gas of the Extracorporeal Circuit during Cardiopulmonary Bypass and Extracorporeal Life…

Abstract Low cardiac output syndrome and the systemic inflammatory response are consequences of the cardiac surgical perioperative course. The mechanisms responsible are multifactorial, but recent studies have shown that nitric..

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The Effect of Priming Solutions and Storage Time on Plasticizer Migration in Different PVC Tubing Types—Implications for Wet Storage of…

Abstract The wet priming of extracorporeal membrane oxygenation systems and storage of these systems for rapid deployment is common practice in many clinical centers. This storage policy is, however, seen..

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Long‐term renal function after venoarterial extracorporeal membrane oxygenation

Abstract Background The utilization of venoarterial extracorporeal membrane oxygenation (VA‐ECMO) as a life‐supporting therapy has increased exponentially over the last decade. As more patients receive and survive ECMO, there are..

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Hypercoagulopathy, acquired coagulation disorders and anticoagulation before, during and after extracorporeal membrane oxygenation in COVID-19: a case series.

Abstract Background: Thromboembolism and bleeding contribute to Coronavirus disease 2019 (COVID-19)’s morbidity and mortality and are also frequent complications of venovenous extracorporeal membrane oxygenation (vvECMO). As the interaction of the..

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Heparin-Free Lung Transplantation on Venovenous Extracorporeal Membrane Oxygenation Bridge.

Abstract Extracorporeal membrane oxygenation (ECMO) bridge to lung transplantation (LuTX) exposes the patients to a high risk of perioperative bleeding secondary to systemic anticoagulation and coagulation factors deficiency. With this..

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Different mechanisms of oxygenator failure and high plasma von Willebrand factor antigen influence success and survival of venovenous extracorporeal membrane…

Abstract Objective Failure of membrane oxygenator (MO) function of venovenous extracorporeal membrane oxygenators (VV ECMO) remains problematic. The development of device-induced coagulation disorder (COD) or worsened gas transfer (WGT) necessitates..

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Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database

Abstract Background Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the..

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Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study

Abstract Background Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using anti-Xa..

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Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study

Abstract Background: To report and compare the characteristics and outcomes of COVID-19 patients on extracorporeal membrane oxygenation (ECMO) to non-COVID-19 acute respiratory distress syndrome (ARDS) patients on ECMO. Methods: We..

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Should we ration extracorporeal membrane oxygenation during the COVID-19 pandemic?

The COVID-19 pandemic has raised challenging questions about the rationing of intensive care unit (ICU) beds, mechanical ventilators, and extracorporeal membrane oxygenation (ECMO).    Experts have recommended that ECMO be..

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Argatroban Anticoagulation for Adult Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Background: Heparin is the widely used anti-coagulation strategy for patients on extracorporeal membrane oxygenation (ECMO). Nevertheless, heparin-induced thrombocytopenia (HIT) and acquired anti-thrombin (AT) deficiency preclude the use of heparin..

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Unusual Complication of a Right Ventricular Support–Extracorporeal Membrane Oxygenation Cannula

Abstract A previously healthy, middle-aged patient presented with rapidly increasing shortness of breath despite empirical antibiotic treatment for presumed pneumonia. A computed tomographic image of the chest was notable for..

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Perioperative circulatory support for lung transplantation.

Abstract Objective Extracorporeal membrane oxygenation (ECMO) has recently replaced cardiopulmonary bypass (CPB) as the preferred option for providing circulatory support during lung transplantation. This review aimed to summarize the previous..

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Simple equations to predict the effects of veno‐venous ECMO in decompensated Eisenmenger syndrome

Abstract Adult patients with uncorrected congenital heart diseases and chronic intracardiac shunt may develop Eisenmenger syndrome (ES) due to progressive increase of pulmonary vascular resistance, with significant morbidity and mortality...

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Red blood cell transfusion requirements for patients on extracorporeal membrane oxygenation

Abstract Background: Extracorporeal membrane oxygenation (ECMO) is a rescue procedure used for cardiac and pulmonary dysfunction. Patients on ECMO often require blood transfusions to maintain oxygen delivery and recover from..

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