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Hybrid and parallel extracorporeal membrane oxygenation circuits

Abstract Extracorporeal membrane oxygenation (ECMO) is one type of extracorporeal life support for patients with cardiopulmonary failure. ECMO may serve as a as bridge to recovery, long-term mechanical support, or..

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The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review

Abstract Objective: Assessment of the results of the ProtekDuo cannula applied for dedicated right ventricular support with oxygenator in ARDS secondary to COVID-19. Methods: Systematic literature search in NHS library,..

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Ultra‑lung‑protective ventilation and biotrauma in severe ARDS patients on veno‑venous extracorporeal membrane oxygenation: a randomized controlled study

Abstract Background: Ultra‑lung‑protective ventilation may be useful during veno‑venous extracorporeal membraneoxygenation (vv‑ECMO) for severe acute respiratory distress syndrome (ARDS) to minimize ventilator‑induced lunginjury and to facilitate lung recovery. The objective..

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Blood flow but not cannula positioning influences the efficacy of Veno-Venous ECMO therapy

Abstract Despite being vital in treating intensive-care patients with lung failure, especially COVID-19 patients, Veno-Venous Extra-Corporeal Membrane Oxygenation does not exploit its full potential, leaving ample room for improvement. The..

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Medical Nutrition Therapy in ECMO Patients: Evidence-Based Guidance for Clinical Practice

Abstract Patients receiving extracorporeal membrane oxygenation (ECMO) inherit substantial disease-associated metabolic, endocrinologic, and immunologic modifications. Along with the technical components of ECMO, the aforementioned alterations may affect patients’ needs and..

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Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model

Abstract Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal..

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Anti-thrombotic Therapy with Cangrelor and Bivalirudin in Venoarterial Extracorporeal Membrane Oxygenation Patients Undergoing Percutaneous Coronary Intervention: A Single-Center Experience

Abstract VA-ECMO is commonly used for patients in cardiogenic shock (CS) or refractory cardiac arrest (CA) undergoing PCI for ACS. In this setting at high risk of both thrombotic and..

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Hemocompatibility challenge of membrane oxygenator for artificial lung technology

Abstract The artificial lung (AL) technology is one of the membrane-based artificial organs that partly augments lung functions, i.e. blood  and CO2 removal. It is generally employed as an extracorporeal membrane  (ECMO) device to..

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Recurrent Candidemia Due to Extracorporeal Membrane Oxygenation Circuit Seeding in Acute Respiratory Distress Syndrome From COVID-19

Abstract Nosocomial infections are a leading complication of prolonged extracorporeal membrane oxygenation (ECMO) therapy, and invasive fungal infections are of particular concern. Candida bloodstream infection specifically is associated with poor outcomes in acute..

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Extracorporeal cardiopulmonary resuscitation in adults and children: A review of literature, published guidelines and pediatric single-center program building experience

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) is an adjunct supportive therapy to conventional cardiopulmonary resuscitation (CCPR) employing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in the setting of refractory cardiac arrest. Its use..

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The effect of arterial cannula tip position on differential hypoxemia during venoarterial extracorporeal membrane oxygenation

Abstract Interaction between native ventricular output and venoarterial extracorporeal membrane oxygenation (VA ECMO) flow may hinder oxygenated blood flow to the aortic arch branches, resulting in differential hypoxemia. Typically, the..

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Parameters associated with successful weaning of veno‑arterial extracorporeal membrane oxygenation: a systematic review

Abstract Purpose: Veno‑arterial (VA) extracorporeal membrane oxygenation (ECMO) can be used to restore organ perfusionin patients with cardiogenic shock until native heart recovery occurs. It may be challenging, however, to..

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A Comparison of Separate Access versus In-Line Configuration for Continuous Renal Replacement Therapy in VV ECMO

Abstract Objective Continuous renal replacement therapy (CRRT) in patients receiving venovenous extracorporeal membrane oxygenation (VV ECMO) can be accessed via separate venous access (SVA) or directly “in-line” within the ECMO circuit...

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Perioperative Circulatory Support and Management for Lung Transplantation: A Case-Based Review

Abstract Lung transplantation (LTx) historically was performed with cardiopulmonary bypass (CPB) or Off-pump. Recent data suggest an increased interest in extracorporeal membrane oxygenation (ECMO) as perioperative circulatory support by many..

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Health-related quality of life, one-year costs and economic evaluation in extracorporeal membrane oxygenation in critically ill adults

Abstract Purpose: This study reports on survival and health related quality of life (HRQOL) after extracorporeal membrane oxygenation (ECMO) treatment and the associated costs in the first year. Materials and..

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Expanding neonatal ECMO criteria: When is the premature neonate too premature

Abstract Extracorporeal membrane oxygenation (ECMO) is a universally accepted and life-saving therapy for neonates with respiratory or cardiac failure that is refractory to maximal medical management. Early studies found unacceptable..

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Heparin Versus Bivalirudin for Anticoagulation in Adult Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) poses unique thrombotic and hemorrhagic risks, and the optimal anticoagulant choice is unknown. We systematically searched Ovid EBM Reviews, Ovid Embase, Ovid Medline, Scopus, and..

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Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life…

Abstract Background Acute brain injury (ABI) remains common after extracorporeal cardiopulmonary resuscitation (ECPR). Using a large international multicenter cohort, we investigated the impact of peri-cannulation arterial oxygen (PaO2) and carbon..

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Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study

Abstract Purpose The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults..

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Knowledge gaps and research priorities in adult veno‑arterial extracorporeal membrane oxygenation: a scoping review

Abstract Purpose: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods: An expert panel was recruited consisting of eight..

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Time course, factors related to, and prognostic impact of venoarterial extracorporeal membrane flow in cardiogenic shock

Abstract Aims Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is currently one of the most used devices in refractory cardiogenic shock. However, there is a lack of evidence on how to set..

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Dutch trial set out to save more lives using Getinge’s Cardiohelp in prehospital care

Abstract A nationwide trial has kicked off in the Netherlands as four Mobile Medical Teams join forces to offer extracorporeal cardiopulmonary resuscitation (ECPR) as rescue therapy for refractory out-of-hospital cardiac arrest...

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Effect of Portable, In-Hospital Extracorporeal Membrane Oxygenation on Clinical Outcomes

Abstract The time between onset of cardiogenic shock and initiation of mechanical circulatory support is inversely related to patient survival as delays in transporting patients to the operating room (OR)..

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Confirmation of Dual Lumen Cannula Position Before Extracorporeal Membrane Oxygenation Initiation Using a Microbubbles Contrast Technique

Abstract Dual lumen cannulas (DLCs) for venovenous extracorporeal membrane oxygenation (ECMO) therapy are introduced in the right internal jugular vein, passing through the superior vena cava and the right atrium (RA) down..

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Impact of occurrence of cardiac arrest in the donor on long-term outcomes of pediatric heart transplantation

Abstract Objective: The impact of cardiac arrest in the donor on long-term outcomes of pediatric heart transplantation has not been studied. Methods: The UNOS database was queried for primary pediatric heart transplantation..

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Fifteen-minute consultation: When to consider extracorporeal membrane oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) is a form of organ support which is used for severe, potentially reversible respiratory, cardiac or cardiorespiratory failure. While it is associated with significant risk..

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In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Abstract Background Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with COVID-19, but uncertainty remains about the determinants of in-hospital mortality and data on post-discharge outcomes are scarce...

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Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation

Abstract Previous studies suggested that contact pathway factors drive thrombosis in mechanical circulation. We used a rabbit model of veno-arterial extracorporeal circulation (VA-ECMO) to evaluate the role of factors XI..

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Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study

Abstract Background In patients receiving venovenous (VV)  (ECMO) packed red blood cell (PRBC) transfusion thresholds are usually higher than in other patients who are critically ill. Available guidelines suggest a restrictive..

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