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Fatigue of red blood cells under periodic squeezes in ECMO

Abstract Hemolysis usually happens instantly when red blood cells (RBCs) rupture under a high shear stress. However, it is also found to happen gradually in the extracorporeal membrane oxygenation (ECMO)..

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Extracorporeal Membrane Oxygenation Cannulation Timing in the Pediatric Myocarditis Population: An Exploratory Analysis From the Extracorporeal Life Support Organization Registry

Abstract OBJECTIVES:  Children presenting with acute myocarditis may experience rapid clinical deterioration requiring extracorporeal membrane oxygenation (ECMO); however, our understanding of best practices and timing of ECMO initiation are lacking...

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Single-Center Experience Using the Cardiohelp System for Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Objectives:  Extracorporeal membrane oxygenation (ECMO) systems have continued to evolve and improve with the development of smaller and portable systems. The Cardiohelp (Maquet Getinge Cardiopulmonary AG, Rastatt, Germany) portable..

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Organ Donation From Patients on Extracorporeal Membrane Oxygenation at the Time of Death

Abstract OBJECTIVES:  To describe the clinical characteristics and organ donation rate of patients supported by extracorporeal membrane oxygenation (ECMO) at the time of death. DESIGN:  Retrospective observational study. Pearson chi-square..

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Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study

Abstract Objectives To determine in patients with acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) whether reducing driving pressure (ΔP) would decrease plasma biomarkers of inflammation..

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Improving access to extracorporeal membrane oxygenation for out of hospital cardiac arrest: pre‑hospital ECPR and alternate delivery strategies

Abstract Background: The use of extracorporeal membrane oxygenation (ECPR) in refractory out-of-hospital cardiac arrest (OHCA) patients is usually implemented in-hospital. As survival in ECPR patients is critically time-dependent, alternative models..

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A novel strategy to reduce the recirculation of venovenous extracorporeal membrane oxygenation: Inferior vena cava closure technology

Abstract The recirculation of venovenous extracorporeal membrane oxygenation (VV-ECMO) will decrease the efficiency of respiratory support. We report a patient with refractory severe acute respiratory distress syndrome (ARDS). Even with..

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Impact of fresh frozen plasma transfusion on mortality in extracorporeal membrane oxygenation

Abstract Background Patients who receive extracorporeal membrane oxygenation (ECMO) support require substantial transfusions. Red blood cell (RBC) and platelet (PLT) transfusions have been reported to be associated with adverse outcomes..

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Gender and the Outcome of Postcardiotomy Veno-arterial Extracorporeal Membrane Oxygenation

Abstract Objective There is a paucity of sex-specific data on patients’ postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO). The present study sought to assess this issue in a multicenter study. Design..

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Optimal Settings at Initiation of Veno-Venous Extracorporeal Membrane Oxygenation: An Exploratory In-Silico Study

Abstract The Extracorporeal Life Support Organisation (ELSO) recommends initiating veno-venous extracorporeal membrane oxygenation (ECMO) with sweep gas flow rate (V˙sweep) of 2 L/min and extracorporeal circuit blood flow (Q˙ec) of 2 L/min...

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One-Year Mental and Physical Health Assessment in Survivors After ECMO for COVID-19-related ARDS

Abstract Rational. Long-term outcomes of patients with COVID-19-related acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO) are unknown. Methods. Multicenter, prospective study in patients who received ECMO..

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Feasibility of using the ProtekDuo cannula in V-P ECMO and PROpella configurations during ground and air transport

Abstract Introduction: Use of the ProtekDuo cannula has been described for right ventricular assist devices (RVADs) and extracorporeal membrane oxygenation (ECMO) systems. Case report: We describe remote cannulation and transport of two..

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Fractured Right Atrial-Pulmonary Artery Cannula (ProtekDuo) in a 164-Day Extracorporeal Membrane Oxygenation Bridge to Lung Transplant

Abstract Fractures of extracorporeal membrane oxygenation (ECMO) cannulas are exceedingly rare due to their woven metal reinforcement. There are only a few cases reported in the literature. We present a 27-year-old..

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An Intensivist-Led Extracorporeal Membrane Oxygenation Program: Design, Implementation, and Outcomes of the First Five Years

Abstract We describe the development, implementation, and outcomes of an intensivist-led adult extracorporeal life support (ECLS) program using intensivists both to perform venovenous (V-V), venoarterial (V-A), and extracorporeal cardiopulmonary resuscitation..

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Retrospective Analysis of Arterial Carbon Dioxide Level and Arterial pH Level at the Time of Initiation of Respiratory ECMO and…

Abstract Introduction  Respiratory extracorporeal membrane oxygenation (ECMO) is well established and its popularity has increased during coronavirus disease 2019 (COVID-19) time. The efficacy of ECMO has been proved in refractory..

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Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation

Abstract OBJECTIVES:  Prone positioning and venovenous extracorporeal membrane oxygenation (ECMO) are both useful interventions in acute respiratory distress syndrome (ARDS). Combining the two therapies is feasible and safe, but the..

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Outcome of extracorporeal membrane oxygenation use in severe accidental hypothermia with cardiac arrest and circulatory instability: A multicentre, prospective, observational…

Abstract Aim To elucidate the effectiveness of extracorporeal membrane oxygenation (ECMO) in accidental hypothermia (AH) patients with and without cardiac arrest (CA), including details of complications. Methods This study was..

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Parallel circuits for refractory hypoxemia on venovenous extracorporeal membrane oxygenation

Abstract Refractory hypoxemia during support on venovenous (VV) extracorporeal membrane oxygenation (ECMO) is a challenging clinical problem. Manipulating ventilator settings, prone positioning, optimizing cannula position, and ECMO flows, and the..

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Hybrid and parallel extracorporeal membrane oxygenation circuits

Abstract Extracorporeal membrane oxygenation (ECMO) is one type of extracorporeal life support for patients with cardiopulmonary failure. ECMO may serve as a as bridge to recovery, long-term mechanical support, or..

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The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review

Abstract Objective: Assessment of the results of the ProtekDuo cannula applied for dedicated right ventricular support with oxygenator in ARDS secondary to COVID-19. Methods: Systematic literature search in NHS library,..

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Ultra‑lung‑protective ventilation and biotrauma in severe ARDS patients on veno‑venous extracorporeal membrane oxygenation: a randomized controlled study

Abstract Background: Ultra‑lung‑protective ventilation may be useful during veno‑venous extracorporeal membraneoxygenation (vv‑ECMO) for severe acute respiratory distress syndrome (ARDS) to minimize ventilator‑induced lunginjury and to facilitate lung recovery. The objective..

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Blood flow but not cannula positioning influences the efficacy of Veno-Venous ECMO therapy

Abstract Despite being vital in treating intensive-care patients with lung failure, especially COVID-19 patients, Veno-Venous Extra-Corporeal Membrane Oxygenation does not exploit its full potential, leaving ample room for improvement. The..

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Medical Nutrition Therapy in ECMO Patients: Evidence-Based Guidance for Clinical Practice

Abstract Patients receiving extracorporeal membrane oxygenation (ECMO) inherit substantial disease-associated metabolic, endocrinologic, and immunologic modifications. Along with the technical components of ECMO, the aforementioned alterations may affect patients’ needs and..

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Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model

Abstract Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal..

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Anti-thrombotic Therapy with Cangrelor and Bivalirudin in Venoarterial Extracorporeal Membrane Oxygenation Patients Undergoing Percutaneous Coronary Intervention: A Single-Center Experience

Abstract VA-ECMO is commonly used for patients in cardiogenic shock (CS) or refractory cardiac arrest (CA) undergoing PCI for ACS. In this setting at high risk of both thrombotic and..

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Hemocompatibility challenge of membrane oxygenator for artificial lung technology

Abstract The artificial lung (AL) technology is one of the membrane-based artificial organs that partly augments lung functions, i.e. blood  and CO2 removal. It is generally employed as an extracorporeal membrane  (ECMO) device to..

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Recurrent Candidemia Due to Extracorporeal Membrane Oxygenation Circuit Seeding in Acute Respiratory Distress Syndrome From COVID-19

Abstract Nosocomial infections are a leading complication of prolonged extracorporeal membrane oxygenation (ECMO) therapy, and invasive fungal infections are of particular concern. Candida bloodstream infection specifically is associated with poor outcomes in acute..

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Extracorporeal cardiopulmonary resuscitation in adults and children: A review of literature, published guidelines and pediatric single-center program building experience

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) is an adjunct supportive therapy to conventional cardiopulmonary resuscitation (CCPR) employing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in the setting of refractory cardiac arrest. Its use..

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The effect of arterial cannula tip position on differential hypoxemia during venoarterial extracorporeal membrane oxygenation

Abstract Interaction between native ventricular output and venoarterial extracorporeal membrane oxygenation (VA ECMO) flow may hinder oxygenated blood flow to the aortic arch branches, resulting in differential hypoxemia. Typically, the..

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