Abstract Background: Population pharmacokinetics (PK) models could provide specific references for the formulation of personal drug delivery protocols, however, there is no population PK study of tranexamic acid (TXA) have been..
Read MoreAbstract Introduction: Indexed oxygen delivery (DO₂i) is a critical parameter in cardiopulmonary bypass (CPB) management. Traditional goal-directed perfusion (GDP) protocols use fixed DO₂i thresholds, typically derived from normothermic conditions. However,..
Read MoreAbstract Purpose Clinicians presume a relationship between the management of blood pressure during cardiac surgery and postoperative morbidity and mortality. With limited evidence to inform practice, we surveyed Canadian cardiac..
Read MoreAbstract Acute kidney injury (AKI) is a frequent and severe problem following heart surgery, particularly in procedures involving cardiopulmonary bypass (CPB). This research investigates the Randomized Controlled Trial (RCT) on..
Read MoreAbstract Background Delirium is a common neurological complication after cardiac surgery. The purpose of the present study was to analyze the association between hemodynamic fluctuations during cardiopulmonary bypass (CPB) and..
Read MoreAbstract Introduction Imbalance in the redox equilibrium is common in any type of aggression. Cardiopulmonary bypass (CPB) initiation induces metabolic perturbations, and reliable biological monitoring tools for this condition are..
Read MoreAbstract Background Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical..
Read MoreAbstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..
Read MoreAbstract Objective Cardiac arrest happens in 0.7%-5.2% patients after cardiovascular surgery, and cases with asystole or severe bradycardia need timely temporary pacing. However, routine temporary pacing wire insertion in cardiopulmonary..
Read MoreAbstract Purpose Neonates undergoing cardiopulmonary bypass (CPB) are at a high risk of a systemic inflammatory response leading to cardiac, respiratory, and renal dysfunction due to their small body size..
Read MoreAbstract Background: Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are widely used. Previous methods to reduce inflammation have shown inconsistent results. We developed a cytokine adsorption column using polymethyl methacrylate..
Read MoreAbstract Background Cardiac surgery is associated with increased risk of major adverse outcomes. Venous to arterial carbon dioxide tension gap (Pv-aCO2 gap) showed significant prognostic value of non-cardiac surgery, while their..
Read MoreAbstract Introduction Cardiopulmonary bypass (CPB) is essential for cardiac surgery but poses risks, including gaseous micro emboli (GME). While the incidence of stroke—a common clinical consequence of embolism—ranges from 1-5%..
Read MoreAbstract Background Acute kidney injury (AKI) is common in children with congenital heart disease following open-heart surgery with cardiopulmonary bypass (CPB). Early AKI detection in critically ill children requires clinician..
Read MoreAbstract The paper published in this issue of the ICVTS by Green and colleagues [] from the University of Hull in the UK addresses an often underestimated yet increasingly recognized issue in..
Read MoreAbstract Background Cardiac surgery is associated with increased risk of major adverse outcomes. Venous to arterial carbon dioxide tension gap (Pv-aCO2 gap) showed significant prognostic value of non-cardiac surgery, while their..
Read MoreAbstract Objective To compare the application and outcomes of femoral versus axillary arterial cannulation in adult patients undergoing surgery for type A aortic dissection. Methods We conducted a retrospective review..
Read MoreAbstract Introduction This retrospective study investigated the relationship between differing thresholds of Conventional Ultrafiltration (CUF) and postoperative hemoglobin (HGB) in cardiac surgery cases involving cardiopulmonary bypass. Methods The study utilized..
Read MoreAbstract Background and Aims Innovative advancements in cardiopulmonary bypass (CPB) configurations, such as surface coating, blood filtration, and miniaturization, aim to reduce gaseous microemboli (GME) that contribute to embolic organ..
Read MoreAbstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..
Read MoreAbstract Vasoplegic syndrome (VS) is a common and potentially life-threatening complication of cardiac surgery with cardiopulmonary bypass (CPB). It presents a significant haemodynamic challenge that is often difficult to manage..
Read MoreAbstract Objective Postoperative pneumonia (POP) frequently complicates cardiac surgery that involves cardiopulmonary bypass (CPB). This study aimed to assess the diagnostic utility of procalcitonin (PCT) for identifying pneumonia after CPB-assisted..
Read MoreAbstract The paper published in this issue of the ICVTS by Green and colleagues [] from the University of Hull in the UK addresses an often underestimated yet increasingly recognized issue in..
Read MoreAbstract A venous reservoir (VR) is crucial for safe blood volume regulation during cardiopulmonary bypass (CPB) procedures. Currently, blood volume measurement in VRs relies heavily on visual inspection, which limits..
Read MoreAbstract Abstract Objective To investigate cerebral autoregulation impairment during neonatal cardiac surgery. Design A retrospective observational study. Setting Single-center, university teaching children’s hospital. Participants Neonates undergoing surgery for critical congenital..
Read MoreAbstract Background Postoperative delirium (POD) remains a significant complication following cardiopulmonary bypass (CPB) surgery, particularly in middle-aged patients who constitute the majority of this surgical population. While intranasal insulin (INI)..
Read MoreAbstract IMPORTANCE: Cardiopulmonary bypass (CPB) surgery is associated with changes in the intestinal microbiome. Metabolism of tryptophan into the indole pathway is entirely facilitated by the intestinal microbiome, and indole..
Read MoreAbstract Background: Plastic-containing medical devices are commonly used in critical care units and other patient care settings. Patients are often exposed to xenobiotic agents that are leached out from plastic-containing..
Read MoreAbstract Background The nadir oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) is reportedly associated with acute kidney injury (AKI) in patients undergoing cardiac surgery. However, there are few reports..
Read MoreAbstract Cardiopulmonary bypass (CPB) impacts pharmacokinetics and -dynamics of drugs used during cardiac surgery. These alterations can lead to changes in drug efficacy resulting in under- or overdosing. This review..
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