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Levosimendan in extracorporeal membrane oxygenation in refractory cardiac arrest

Abstract Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can re-establish tissue perfusion in refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR). Levosimendan showed potential benefit in VA-ECMO weaning and mortality but was not..

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Albumin Infusion Reduces Fluid Loading for Postresuscitation Syndrome in a Pig Model of Refractory Cardiac Arrest Resuscitated With Venoarterial Extra…

Abstract Hemodynamic instability in postresuscitation syndrome worsens survival and neurological outcomes. Venoarterial extracorporeal membrane oxygenation (VA ECMO) for refractory cardiac arrest might improve outcomes. Hemodynamical support under VA ECMO relies..

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Lower Versus Higher Oxygenation Targets for Critically Ill Patients: A Systematic Review

Abstract Supplemental oxygen is a standard therapeutic intervention for critically ill patients such as patients suffering from cardiac arrest, myocardial ischemia, traumatic brain injury, and stroke. However, the optimal oxygenation..

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Extracorporeal Blood Purification with CytoSorb in 359 Critically Ill Patients

Abstract Introduction: Critically ill patients with inflammatory dysregulation and organ disfunction may benefit from blood purification, although the use of this technique has not been described in large case series. We..

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Children who suffer cardiac arrest more likely to survive at ECMO capable hospitals

Abstract Children who experience cardiac arrest are one and a half times more likely to survive at a hospital capable of providing the life support system called ECMO, research suggests...

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Efficacy of CytoSorb®: a systematic review and meta-analysis

Abstract Introduction Cytokine adsorption using the CytoSorb® adsorber has been proposed in various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac surgery or recovery after cardiac arrest. The aim of..

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Oxygen Delivery Thresholds During Cardiopulmonary Bypass and Risk for Acute Kidney Injury

Abstract Background Postoperative acute kidney injury (AKI) in cardiac surgery patients is multifactorial and associated with low oxygen delivery (DO2) during cardiopulmonary bypass. Methods Cardiac surgical patients undergoing full cardiopulmonary..

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Organ Donation After Out-of-Hospital Cardiac Arrest: A Scientific Statement From the International Liaison Committee on Resuscitation

Abstract Aim of the Review: Improving rates of organ donation among patients with out-of-hospital cardiac arrest who do not survive is an opportunity to save countless lives. The objectives of..

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Defibrillation Strategies for Refractory Ventricular Fibrillation

Abstract BACKGROUND Despite advances in defibrillation technology, shock-refractory ventricular fibrillation remains common during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED; rapid sequential shocks from two defibrillators) and vector-change (VC)..

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Serum lactate in refractory out-of-hospital cardiac arrest: Post-hoc analysis of the Prague OHCA study

Abstract Background The severity of tissue hypoxia is routinely assessed by serum lactate. We aimed to determine whether early lactate levels predict outcomes in refractory out-of-hospital cardiac arrest (OHCA) treated..

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ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation

Abstract Purpose: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a complex and high-risk life support modality used in severe cardiorespiratory failure. ECMO survival scores are used clinically for patient prognostication and..

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Distal perfusion cannula on VA-ECMO: do not blindly trust! A case report

Abstract Distal perfusion cannulas, DPCs, are increasingly used to prevent limb ischemia, frequent and potentially serious complication on peripheral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support. We report the case..

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Extracorporeal life support in thoracic emergencies—a narrative review of current evidence

Abstract Background and Objective: Resuscitative therapies for respiratory and cardiac failure are lifesaving and extended by using extracorporeal life support (ECLS) as mechanical circulatory support (MSC). This review informs the debate..

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Mechanical life support algorithm for the emergency management of patients with left-sided Impella

Abstract We sought to remedy the limited guidance that is available to support the resuscitation of patients with the Impella Cardiac Power (CP) and 5.0 devices during episodes of cardiac..

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ECPR for refractory OHCA – lessons from 3 randomized controlled trials. The trialists´view

Abstract Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST-trial, Prague OHCA study, and INCEPTION-trial) that addressed the clinical benefit of ECPR..

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Veno-Arterial Extracorporeal Membrane Oxygenation for Amniotic Fluid Embolism: A Report From the Extracorporeal Life Support Organization Registry

Abstract Amniotic fluid embolism (AFE) is a potentially lethal complication of pregnancy that results from disruption of the maternal–fetal interface and occurs as frequently as one in every 8,000 deliveries. When AFE..

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On-Support and Post-Weaning Mortality in Post-Cardiotomy Extracorporeal Membrane Oxygenation

Abstract BACKGROUND Post-cardiotomy veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is characterized by discrepancies between weaning and survival-to-discharge rates. This study analyzes the differences between post-cardiotomy V-A ECMO patients who survived,..

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Extracorporeal Life Support Organization Center of Excellence recognition is associated with improved failure to rescue after cardiac arrest

Abstract Objective The influence of Extracorporeal Life Support Organization (ELSO) center of excellence (CoE) recognition on failure to rescue after cardiac surgery is unknown. We hypothesized that ELSO CoE would..

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Neuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support

Abstract Objective There is limited evidence on standardized protocols for optimal neurological monitoring methods  receiving  (ECMO). We previously introduced protocolized noninvasive multimodal neuromonitoring using serial , electroencephalography,  ultrasound, and . The purpose of this study..

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Association between enteral feeding and gastrointestinal complications in children receiving extracorporeal life support: A retrospective cohort study

Abstract Background Extracorporeal life support is an accepted treatment modality for children with severe cardiac and/or respiratory dysfunction. However, after a period of inadequate gut perfusion, clinicians are often reluctant..

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Cardiac arrest and cardiopulmonary resuscitation in pediatric patients with cardiac disease: a narrative review

Abstract Children with cardiac disease are at a higher risk of cardiac arrest as compared to healthy children. Delivering adequate cardiopulmonary resuscitation (CPR) can be challenging due to anatomic characteristics,..

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Coronary angiography findings in resuscitated and refractory out-of-hospital cardiac arrest: A systematic review and meta-analysis

Abstract Introduction Coronary angiography (CAG) frequently reveals coronary artery disease (CAD) after out-of-hospital cardiac arrest (OHCA), but its use is not standardized and often reported in different subpopulations. This systematic..

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What is the potential benefit of pre-hospital extracorporeal cardiopulmonary resuscitation for patients with an out-of-hospital cardiac arrest? A predictive modelling…

Abstract Aim In this  study we aimed to investigate how many  with an out-of-hospital cardiac arrest (OHCA) would benefit from pre-hospital as opposed to in-hospital initiation of  cardiopulmonary resuscitation (ECPR). Methods A  of Utstein..

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Blood versus crystalloid cardioplegia during triple valve surgery: A single center experience

Abstract Background The efficacy of different cardioplegia solutions on outcomes of complex cardiac operations such as triple valve surgery (TVS) is scarce. Here we compared the outcomes in TVS patients..

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Evaluation of Vasoactive-Inotropic Score and Survival to Decannulation in Adult Patients on Venoarterial Extracorporeal Life Support: An Observational Cohort Study

Abstract Extracorporeal life support with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used to assist circulation in patients with severe cardiogenic shock or cardiac arrest. The vasoactive-inotropic score (VIS) is a standardized calculation of vasoactive medication support which uses..

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Hospital ECMO capability is associated with survival in pediatric cardiac arrest

Abstract Aim Extracorporeal membrane oxygenation (ECMO) provides temporary support in severe cardiac or respiratory failure and can be deployed in children who suffer cardiac arrest. However, it is unknown if..

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Extracorporeal Cardiopulmonary Resuscitation for Cardiac Arrest

Abstract Cardiac arrest affects approximately 600 000 people in the US yearly and is associated with a survival rate of 10% to 12% for out-of-hospital cardiac arrests and 25% to 30%..

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Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis

Abstract Background Although outcomes of patients after cardiac arrest remain poor, studies have suggested that extracorporeal cardiopulmonary resuscitation (ECPR) might improve survival and neurological outcomes. We aimed to investigate any..

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The impact of levosimendan on survival and weaning from ECMO after extracorporeal cardiopulmonary resuscitation

Abstract Objectives Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly used due to its beneficial outcomes and results compared to conventional CPR. After cardiac arrest, the overall ejection fraction is severely impaired;..

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Extracorporeal CPR after the INCEPTION trial: No one steps twice into the same river

Abstract The use of veno-arterial extracorporeal membrane oxygenation as extracorporeal cardiopulmonary resuscitation in patients suffering out-of-hospital cardiac arrest, largely increased in the last decade despite evidence supporting this practice being..

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