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Methylene Blue for Vasoplegia When on Cardiopulmonary Bypass During Double-Lung Transplantation

Abstract Vasoplegia syndrome, characterized by hypotension refractory to fluid resuscitation or high-dose vasopressors, low systemic vascular resistance, and normal-to-increased cardiac index, is associated with increased morbidity and mortality after cardiothoracic..

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Are We Overdiagnosing Acute Kidney Injury in Pediatric Patients Following Cardiac Surgery?

Abstract Background: The use of two diagnostic criteria in the current literature has led to some degree of ambiguity in the precise diagnosis of acute kidney injury in pediatric patients..

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Outcome after aortic valve replacement in children: A systematic review and meta-analysis

Abstract Objective Despite an increasing interest in pediatric  repair,  in children may be unavoidable. The evidence on outcome after pediatric aortic valve replacement is limited and usually reported in small case series...

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Hyperbilirubinemia after cardiac surgery: An observational study

Abstract Background We aimed to assess the incidence and perioperative risk factors for hyperbilirubinemia after cardiac surgery, and determine its influence on early operative outcome. Methods This prospective observational study..

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2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients

Abstract Post-cardiotomy extracorporeal life support (PC-ECLS) in adult patients has been used only rarely but recent data have shown a remarkable increase in its use, almost certainly due to improved..

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Central extracorporeal membrane oxygenation for refractory pediatric septic shock

Abstract Objective: To demonstrate positive outcome, to achieve higher flow rates, and to reverse shock more quickly by implementing central extracorporeal membrane oxygenation (ECMO) in children with refractory septic shock. Children..

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Extracorporeal Membrane Oxygenation for Adults With Refractory Septic Shock

Abstract Because of a severe dysregulation of the host response to infection, septic shock may induce a profound imbalance between oxygen consumption and delivery, which in some cases may be..

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Neonatal Closure of Apical Ventricular Septal Defect

Abstract A 2-week-old, 3.5 kg child was transferred from a distant hospital (300 miles away) on congestive heart failure. Suspected diagnosis was ventricular septal defect (VSD), atrial septal defect (ASD),..

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Publication in The New England Journal of Medicine shows complications after liver transplantation significantly reduced with cold, oxygenated machine perfusion.

Abstract An article published in the scientific journal The New England Journal of Medicine, shows that oxygenated perfusion of the donated liver before transplantation has a significant positive impact on..

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Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs

Abstract Background Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are..

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The Hemovent Oxygenator: A New Low-Resistance, High-Performance Oxygenator

Abstract Extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) provide respiratory support aimed at gaining time to allow patient’s recovery from hypoxemic and/or hypercapnic respiratory failure, respectively. However, in..

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Minimum Alveolar Concentration of Sevoflurane as a Single Hypnotic Agent to Maintain BIS Below 50 in Patients During Normothermic Cardiopulmonary…

Abstract Objectives Minimum alveolar concentration (MAC) of volatile anesthetic agents to maintain bispectral index (BIS) below 50 in 50% of patients was defined as MACBIS50. The primary objective of this..

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Successful Antithrombin Administration in Andexanet Alfa-Associated Heparin Resistance

Abstract Case Report A 72-year-old man with a tachycardiomyopathy, atrium flutter, and atrial fibrillation underwent an elective radiofrequency ablation procedure. In addition to 5 mg of apixaban twice daily, his..

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Thromboelastometry, Thromboelastography, and Conventional Tests to Assess Anticoagulation During Extracorporeal Support: A Prospective Observational Study

Abstract Optimal anticoagulation monitoring in patients with extracorporeal membrane oxygenation (ECMO) is fundamental to avoid hemorrhagic and thromboembolic complications. Besides conventional coagulation tests, there is growing interest in the use..

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Extracorporeal membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: A systematic review and meta‐analysis

Abstract Background COVID‐19 can lead to acute respiratory distress syndrome (ARDS). Extracorporeal membrane oxygenation (ECMO) is considered to be a salvage strategy for severe ARDS. However, the effect of ECMO..

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The Role of Hyperthermic Intraperitoneal Chemotherapy in Pseudomyxoma Peritonei After Cytoreductive Surgery

Abstract Importance  Studies on the prognostic role of hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei (PMP) are currently not available. Objectives  To evaluate outcomes after cytoreductive surgery (CRS) and HIPEC compared with..

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Observational study of thrombosis and bleeding in COVID-19 VV ECMO patients

Abstract Introduction: COVID-19 has been associated with increased risk of thrombosis, heparin resistance and coagulopathy in critically ill patients admitted to intensive care. We report the incidence of thrombotic and..

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Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

Abstract Objective Aortic surgery often causes massive bleeding due to hypofibrinogenemia. Predicting hypofibrinogenemia is useful for developing a hemostasis strategy, including preparing for blood transfusion. We made a formula for..

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Correlating Oxygen Delivery on Cardiopulmonary Bypass with Society of Thoracic Surgeons Outcomes Following Cardiac Surgery

Abstract Background The relationship between low oxygen delivery (DO2) on cardiopulmonary bypass and morbidity and mortality following cardiac surgery remains unexamined. Methods We reviewed patients undergoing Society of Thoracic Surgeons..

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Mitral valve surgery: current status and future prospects of the minimally invasive approach

Abstract Introduction. During the past five years the approach to procedural planning, operative techniques and perfusion strategies for minimally invasive mitral valve surgery (MIMVS) has evolved. With the goal to..

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Organ donation after controlled cardiocirculatory death: confidence by clarity

Abstract Even if an impressive number of 6.337 organs from 1837 donors were transplanted in the Eurotransplant region in 2020 (a reduction of 667 donors compared to 2019), at the..

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Mechanisms of oxidative stress and myocardial protection during open-heart surgery

Abstract We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine Cold heart protection via cardioplegia administration, limits the amount of oxygen demand. Systemic normothermia..

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The effect of obesity on acute kidney injury after cardiac surgery

Abstract Objective Postoperative  is a frequent and serious consequence of cardiac surgery. We undertook to investigate the association of obesity and the risk of acute kidney injury development after cardiac surgery...

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Cytoreduction and hyperthermic intraperitoneal chemotherapy: The learning curve reassessed

Abstract Background  and  (CRS-HIPEC) is now the preferred treatment of many peritoneal surface malignancies. In this retrospective study we aimed to analyze how several performance indicators changed during the first 100..

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Inotropes

Abstract  are a heterogenous group of drugs that modify calcium handling and alter the force of . , and their synthetic analogues, increase  by activating cyclic adenosine monophosphate (cAMP) or  (IP3).  block , which in turn..

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Mannose-binding lectin (MBL) insufficiency protects against the development of systemic inflammatory response after pediatric cardiac surgery

Abstract We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine proteases (MASP-1, MASP -2), in relation to complications following cardiac surgery in 195 children...

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Vasopressinase Activity: A Potential Early Biomarker for Detecting Cardiopulmonary Bypass-Associated Acute Kidney Injury?

Abstract Background Acute kidney injury (AKI) is a common and serious complication of surgeries that include cardiopulmonary bypass (CPB). Currently, increases in serum creatinine levels are used to diagnose AKI,..

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Principles of cardiac anaesthesia

Abstract Cardiac surgical outcomes in the UK have consistently improved despite increasing procedure complexity and ‘sicker’ patients. Numerous anaesthetic techniques are employed with no definitive evidence clearly demonstrating superiority of..

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Migrated Avalon Veno‐Venous Extracorporeal Membrane Oxygenation Cannula: How to Adjust Without Interruption of Flow

Abstract The Avalon dual lumen cannula is presently the cannula of choice for veno‐venous extracorporeal membrane oxygenation (VV‐ECMO) via right internal jugular cannulation. This cannula establishes VV‐ECMO with a single..

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Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery

Abstract BACKGROUND:  Hypomagnesemia has been associated with an increased risk of postoperative atrial fibrillation (POAF). Although previous studies have suggested a beneficial effect of magnesium (Mg) therapy, almost all of..

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