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How would we treat our own heparin-induced thrombocytopenia during cardiac surgery?

Abstract The aim of this article is to provide a comprehensive review of the current state of knowledge on heparin-induced thrombocytopenia (HIT) in cardiac surgery. The management of HIT patients..

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Are We Ready for Hyperthermic Intraperitoneal Chemotherapy in the Upfront Treatment of Ovarian Cancer?

Abstract Advanced epithelial ovarian cancer (EOC) has a well-characterized pattern of spread; the cancer cells tend to stay within the peritoneal cavity, attaching to organ surfaces and only invading superficial..

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NNeMo (Neonatal NeuroMonitor) - a hybrid optical system to characterize perfusion and metabolism in the newborn brain

Abstract Premature birth, defined as a gestational period less than 37 weeks, occurs in 8% of infants born in Canada. These births are associated with a higher risk of developing..

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality

Abstract Importance   Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use. Objective  ..

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Thromboembolic and Bleeding Events in COVID-19 Patients receiving Extracorporeal Membrane Oxygenation

Abstract   Background Extracorporeal membrane oxygenation (ECMO) is a potential treatment option in critically ill COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) if mechanical ventilation (MV) is insufficient;..

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Intraoperative Urinary Biomarkers and Acute Kidney Injury After Cardiac Surgery

Abstract Objectives To evaluate the association of intraoperative urinary biomarker excretion during cardiac surgery and the subsequent development of acute kidney injury (AKI). Design Prospective, nonrandomized, observational study. Setting Single..

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Oxygen delivery-guided perfusion for the prevention of acute kidney injury: A randomized controlled trial

Abstract Objectives The reduction of postoperative acute kidney injury in patients undergoing cardiopulmonary bypass surgery using an oxygen delivery-guided perfusion strategy (oxygen delivery strategy) for cardiopulmonary bypass management compared with..

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Monitoring of the Progression of the Perioperative Serum Lactate Concentration Improves the Accuracy of the Prediction of Acute Mesenteric Ischemia…

Abstract Objectives To examine the sensitivity and specificity of perioperative lactate gradients for the prediction of subsequent  development in patients undergoing cardiovascular surgery. Design Retrospective, single-center, case-control study. Setting University hospital...

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Initial Single-center Experience of PIPAC in Patients With Unresectable Peritoneal Metastasis

Abstract Introduction Peritoneal carcinomatosis remains a condition with poor prognosis and limited therapeutic options. Pressurized Intrapertioneal Aerosol Chemotherapy (PIPAC) has been developed as a new tool for delivering intraperitoneal chemotherapy..

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The Use of Extracorporeal Circulation in Suspected Brain Dead Organ Donors with Cardiopulmonary Collapse

Abstract Bleeding and thrombosis-related complications are common in pediatric cardiac patients supported by extracorporeal membrane oxygenation (ECMO) and are associated with morbidity and mortality. The purpose of this study was..

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Effective Use of Reporting Guidelines to Improve the Quality of Surgical Research

Abstract Historically, the surgical literature was defined based on a predominance of case series, case reports, and anecdotal experiences of surgical investigators. But over the past several decades, the methodologic..

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Clinical and Hematological Outcomes of Aminocaproic Acid Use During Pediatric Cardiac ECMO

Abstract Donor shortage is a major limitation in organ transplantation. Several studies have reported that extracorporeal membrane oxygenation (ECMO)-assisted organ donation can be successfully completed without inducing warm ischemia in..

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Traditional and emerging technologies for washing and volume reducing blood products

Abstract Millions of blood components including red blood cells, platelets, and granulocytes are transfused each year in the United States. The transfusion of these blood products may be associated with..

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Intraoperative Cell Saving: Is the Solution the Actual Problem?

Abstract Allogenic blood is a scarce, precious, and expensive resource that is not always available on demand. After termination of cardiopulmonary bypass, a large amount of residual pump blood remains..

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The risk of performing cardiopulmonary bypass in malaria patients: a small case series

Abstract The effects of cardiopulmonary bypass on patients who have active or dormant malaria are unknown. What is known is that malaria-induced hemolysis can be exacerbated by cardiopulmonary bypass. We..

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Extracorporeal membrane oxygenation in non‑intubated immunocompromised patients

Abstract Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has become an integral part in the rescue therapy of severe acute respiratory distress syndrome (ARDS) and may be lifesaving in patients with..

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Propofol pharmacokinetics and pharmacodynamics—a perspective in minimally invasive extracorporeal circulation

Abstract There is limited evidence as to the pharmacokinetic changes expected in adults with extracorporeal technologies. Drugs may be taken up by various components of the cardiopulmonary bypass circuit itself...

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Does Targeted Temperature Management Improve Neurological Outcome in Extracorporeal Cardiopulmonary Resuscitation (ECPR)?

Abstract Purpose: Targeted temperature management (TTM) is a standard of care in patients after cardiac arrest for neuroprotection. Currently, the effectiveness and efficacy of TTM after extracorporeal cardiopulmonary resuscitation (ECPR)..

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Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial

Abstract Purpose We compared a restrictive fluid management strategy to usual care among critically ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation. Methods This multicenter..

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Effect of cardiopulmonary bypass reoxygenation on myocardial dysfunction following pediatric tetralogy of Fallot repair

Abstract Background Little is known regarding the effect of cardiopulmonary bypass (CPB) reoxygenation on cardiac function following tetralogy of Fallot repair. We hypothesized that hyperoxic reoxygenation would be more strongly..

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The relationship between cardiac surgeon experience and average patient risk profile: CA and NY statewide analysis

Abstract Background It is unknown how high and low‐risk cases are distributed among cardiac surgeons of different experience levels. The purpose of this study was to determine if high and..

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Patients' exposure to PVC plasticizers from ECMO circuits

Abstract Background: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but..

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Markers of Elevated Left Ventricular Filling Pressure Are Associated with Increased Mortality in Nonsevere Aortic Stenosis

Abstract Background Echocardiographic measures of elevated left ventricular filling pressures are associated with an adverse prognosis. The aim of this study was to determine the relationship between acute (ratio of..

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Myocardial Protection in Adult Cardiac Surgery With del Nido Versus Blood Cardioplegia: A Systematic Review and Meta-Analysis

Abstract Background  in adult cardiac surgery is commonly achieved with either multidose blood  or single-dose del Nido crystalloid cardioplegia. Aim The aim of this systematic review and meta-analysis was to compare..

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Is Extracorporeal Membrane Oxygenation the Standard Care for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

Abstract Background  (ARDS) is a type of  syndrome characterised by severe respiratory distress and stubborn . Patients with ARDS have a prolonged hospital stay and high mortality rate. Over long-term follow-up, ARDS..

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The Inverse Relationship Between Endothelium-Dependent Vasodilation and Blood Pressure is Lost After Cardiopulmonary Bypass

Abstract Cardiopulmonary bypass (CPB) is required for the surgical correction of congenital heart defects and incites an acute inflammatory response that impairs endothelial function post-operatively. Therefore, we hypothesized that the..

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Identification of risk factors for renal failure after cardiac surgery by RFILE classification

Abstract Objective: Acute kidney injury (AKI) is a major complication after cardiovascular surgery. The unclear etiology of this highly complex event challenges definition, diagnosis and prediction of AKI, and hence..

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Cerebral oxygen saturation (rSO2) during cardiopulmonary bypass (CPB) measured using the INVOS oximeter closely correlates with baseline rSO2

Abstract Baseline cerebral regional saturation (rSO2) measured using the INVOS 5100C (Medtronic, MN, USA) varies widely among patients with cardiac and/or renal diseases. To identify significant correlates of baseline rSO2 and..

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Pump flow setting and assessment of unloading in clinical practice

Abstract The rationale for mechanical circulatory support (MCS) in cardiogenic shock is to restore cardiac output in selected patients when critically low or in case of refractory cardiac arrest. Furthermore,..

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Long-Term Cognitive Outcomes and Sleep in Adults After Extracorporeal Life Support

Abstract Objectives: To assess differences in cognitive outcomes and sleep in adult survivors of critical illness, managed with venovenous extracorporeal membrane oxygenation as compared to conventional mechanical ventilation only. Design:..

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