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Paving the Road for the Adoption of Normothermic Regional Perfusion in Canada

Abstract Donation after circulatory determination of death has increased the number of organs available but can result in worse recipient outcomes than organs recovered from donors after neurologic death. Normothermic..

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Extracorporeal membrane oxygenation in the forensic setting: A series of 19 forensic cases

Abstract Extracorporeal membrane oxygenation (ECMO) employs vascular cannulation and a gas exchange circuit to provide support to patients with severely compromised cardiopulmonary function. ECMO is often the last intervention taken..

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Recovery of platelet-rich red blood cells and acquisition of convalescent plasma with a novel gravity-driven blood separation device

Abstract Objectives Our objectives were to determine the separation characteristics and blood product quality of a gravity-driven microfiltration blood separation system (HemoClear, The Netherlands). Background A range of centrifugal blood..

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Near-infrared spectroscopy for perioperative assessment and neonatal interventions

Abstract Perioperative applications of near-infrared spectroscopy (NIRS) to monitor regional tissue oxygenation and perfusion in cardiac and noncardiac surgery are of increasing interest in neonatal care. Complex neonatal surgery can..

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Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient

Abstract Background Extra-corporeal membrane oxygenation (ECMO) is a life-saving intervention for severe respiratory and cardiac diseases. However, 50% of survivors have abnormal neurologic exams. Current ECMO management is guided by..

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Very low blood flow carbon dioxide removal system is not effective in a chronic obstructive pulmonary disease exacerbation setting

Abstract Extracorporeal carbon dioxide removal (ECCO2R) is a low blood flow veno-venous extracorporeal membrane oxygenation technique that provides artificial blood CO2 removal. Recently, a new ECCO2R system (PrismaLung), providing very low..

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Safety of intra-operative blood salvage during liver transplantation in patients with hepatocellular carcinoma, a propensity score-matched survival analysis

Abstract Intra-operative blood salvage (IBS) reduces the use of allogeneic blood transfusion. However, safety of IBS during liver transplantation (LT) for hepatocellular carcinoma (HCC) is questioned due to fear for..

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Le prime linee guida per l'uso dell'ECMO nei pazienti pediatrici sottoposti a trapianto di cellule staminali ematopoietiche

Abstract È l’Ospedale Pediatrico Bambino Gesù, in collaborazione con 5 società scientifiche internazionali, a mettere per la prima volta a disposizione di rianimatori e oncoematologi le Linee Guida per il trattamento con ossigenazione extracorporea..

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Right Heart Dysfunction in Adults With Coarctation of Aorta: Prevalence and Prognostic Implications

Abstract BACKGROUND: Chronic elevation of left heart filling pressure causes pulmonary vascular remodeling, pulmonary hypertension, and right heart dysfunction. Although diastolic dysfunction is relatively common in patients with coarctation of aorta,..

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Use of Extracorporeal Membrane Oxygenation as Bridge to Replacement Therapies in Cardiogenic Shock: Insights From the Extracorporeal Life Support Organization

Abstract Background: There has been increasing use of extracorporeal membrane oxygenation (ECMO) as bridge to heart transplant (orthotopic heart transplant [OHT]) or left ventricular assist device (LVAD) over the last..

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Sequestration of Midazolam, Fentanyl, and Morphine by an Ex Vivo Cardiopulmonary Bypass Circuit

Abstract Cardiopulmonary bypass (CPB) circuits can significantly sequester intravenous anesthetics. Adsorption of medications by our institution’s standard circuit (Terumo CAPIOX FX05 oxygenator; noncoated polyvinylchloride tubing) has not been described. We..

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Integration Process With a Donated Heart

Abstract Background  In the posttransplant period, recipients face a complex phenomenon called the new heart, which is a symbol of physical and emotional life. They use different methods to get..

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The global outbreak of Mycobacterium chimaera infections in cardiac surgery-a systematic review of whole-genome sequencing studies and joint analysis

Abstract Background: With the increasing dimensions of the international cardiac surgery-associated Mycobacterium chimaera outbreak the hypothesis of a point source arose. Objectives: To review the published evidence of clonality among cardiac surgery-associated..

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Therapeutic Modulation of the Host Defense by Hemoadsorption with CytoSorb®—Basics, Indications and Perspectives—A Scoping Review

Abstract The “normal” immune response to an insult triggers a highly regulated response determined by the interaction of various immunocompetent cells with pro- and anti-inflammatory cytokines. Under pathologic conditions, the..

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The global outbreak of Mycobacterium chimaera infections in cardiac surgery-a systematic review of whole-genome sequencing studies and joint analysis

Abstract Background: With the increasing dimensions of the international cardiac surgery-associated Mycobacterium chimaera outbreak the hypothesis of a point source arose. Objectives: To review the published evidence of clonality among cardiac surgery-associated..

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Ocular surface microcirculation is better preserved with pulsatile versus continuous flow during cardiopulmonary bypass - an experimental pilot

Abstract Background Non-pulsatile cardiopulmonary bypass may induce microvascular dysregulation. In piglets, we compared ocular surface microcirculation during pulsatile versus continuous flow bypass. Methods Ocular surface microcirculation in small tissue volumes..

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Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Abstract Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements..

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Real-Time Ventricular Volume Measured Using the Intracardiac Electromyogram

Abstract Left ventricular end-diastolic volume (EDV) is an important parameter for monitoring patients with left ventricular assist devices (LVADs) and might be useful for automatic LVAD work adaptation. However, continuous..

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Ventilation during cardiopulmonary bypass did not attenuate inflammatory response or affect postoperative outcomes

Abstract Introduction: Cardiopulmonary bypass causes a series of inflammatory events that have adverse effects on the outcome. The release of cytokines, including interleukins, plays a key role in the pathophysiology of..

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Mobile devices and wearable technology for measuring patient outcomes after surgery: a systematic review

Abstract Complications following surgery are common and frequently occur the following discharge. Mobile and wearable digital health interventions (DHI) provide an opportunity to monitor and support patients during their postoperative..

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Adrenaline improves regional cerebral blood flow, cerebral oxygenation and cerebral metabolism during CPR in a porcine cardiac arrest model using…

Abstract Background The effects of adrenaline on cerebral blood vessels during cardiopulmonary resuscitation (CPR) are not well understood. We developed an extracorporeal CPR model that maintains constant low systemic blood..

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Early experience with donation after circulatory death heart transplantation using normothermic regional perfusion in the United States

Abstract Objective This pilot study sought to evaluate the feasibility of our donation after circulatory death (DCD) heart transplantation protocol using cardiopulmonary bypass (CPB) for normothermic regional reperfusion (NRP). Methods..

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The Effect of Low Tidal Volume Ventilation on Inflammatory Cytokines During Cardiopulmonary Bypass

Abstract Introduction: Halting ventilation during cardiopulmonary bypass (CPB) is implemented to operate in a less bleeding setting. It sustains a better visualization of the operation area and helps to perform the..

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Limb Amputation Following Extracorporeal Membrane Oxygenation Therapy Among Survivors: A Nationwide Cohort Study from South Korea

Abstract We aimed to investigate the incidence of limb amputation due to vascular complications related to extracorporeal membrane oxygenation (ECMO) therapy among survivors and examine its association with long-term mortality in these..

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How Perfusion School Has Changed: Past, Present & Future

Abstract The past 60 years have witnessed a major evolution in clinical cardiopulmonary perfusion education. Much of this progress can be attributed to the continued advancement of medical and surgical..

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Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury

Abstract An essential procedure for the treatment of myocardial infarction is restoration of blood flow in the obstructed infarct artery, which may cause ischaemia/reperfusion (I/R) injury. Heart I/R injury manifests..

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Early and long-term results of hypothermic circulatory arrest in aortic surgery: a 20-year single-centre experience

Abstract Aims  The aim of this study was to document the postoperative outcomes of patients who underwent hypothermic circulatory arrest (HCA), the evolution of HCA management over time and to identify the..

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The use of innominate artery cannulation for antegrade cerebral perfusion in aortic dissection

Abstract Background Direct cannulation of the innominate artery for selective antegrade cerebral perfusion has been shown to be safe in elective proximal aortic reconstructions. We sought to evaluate the safety..

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What Is the Best Strategy for Brain Protection in Patients Undergoing Aortic Arch Surgery? A Single Center Experience of 636…

Abstract Background Cerebral protection during  can be performed using various surgical strategies. We retrospectively analyzed our results of different brain protection modalities during aortic arch surgery. Methods Between January 2003 and..

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Survival and Factors Associated with Survival with Extracorporeal Life Support During Cardiac Arrest

Abstract The survival rate after cardiac arrest (CA) remains low. The utilization of extracorporeal life support is proposed to improve management. However, this resource-intensive tool is associated with complications and..

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