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Nicorandil attenuates ventricular dysfunction and organ injury after cardiopulmonary bypass

Abstract Background Nicorandil, an adenosine triphosphate-sensitive potassium channel agonist and nitric oxide donor, is a coronary vasodilator used to treat ischemia-induced chest pain, but it's potential cardioprotective benefits during open..

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An Arrow Through the Heart

Abstract 54-year-old man suffered a self-inflicted penetrating chest wound from an automated crossbow used for hunting large animals (), with an entrance wound in the left third intercostal space and..

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Trends in Adverse Event Rates in Hospitalized Patients, 2010-2019

Abstract Importance  Patient safety is a US national priority, yet lacks a comprehensive assessment of progress over the past decade. Objective  To determine the change in the rate of adverse events in..

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Extracorporeal CO2 Removal During Renal Replacement Therapy to Allow Lung-Protective Ventilation in Patients with COVID-19–Associated Acute Respiratory Distress Syndrome

Abstract The aim of this retrospective multicenter observational study is to test the feasibility and safety of a combined extracorporeal CO2 removal (ECCO2R) plus renal replacement therapy (RRT) system to use..

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Elimination of CO2 insufflation-induced hypercapnia in open heart surgery using an additional venous reservoir

Abstract   OBJECTIVES Carbon dioxide (CO2) gas insufflation is used for continuous de-airing during open heart surgery. The aim was to evaluate if an additional separate venous reservoir eliminates CO2 insufflation-induced..

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Predictors of weaning failure in case of VA ECMO implantation

Abstract The use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for the treatment of refractory cardiogenic shock has increased signifcantly. Nevertheless, early weaning may be advisable to reduce the potential..

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Del Nido cardioplegia: from an infant conceive to an adult life - a brief review of the current evidence in…

Abstract The increasing number of minimally invasive procedures prompted the quest for a simple and effective single shot cardioplegia to allow the surgeons to focus on their workflow. The originally..

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Novel Left Atrial Cannulation Technique for Attachment of a Pumpless Artificial Lung

Abstract A pumpless artificial lung has the potential to provide a bridge to recovery or transplantation in children with respiratory failure. Pulmonary artery inflow and left atrial outflow are necessary..

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Postoperative but not preoperative depression is associated with cognitive impairment after cardiac surgery: exploratory analysis of data from a randomized…

Abstract Background In this study we hypothesize that depression is associated with perioperative neurocognitive dysfunction and altered quality of life one month after surgery. Methods Data were obtained as part..

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Characteristics and Outcomes of Candidemia in Patients with Durable Left Ventricular Assist Device Support

Abstract There are limited data on the characteristics and clinical course of fungal infections in patients on durable left ventricular assist device (LVAD) support. We sought to further characterize the..

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Augmented reality in medical education: students’ experiences and learning outcomes

Abstract Augmented reality (AR) is a relatively new technology that allows for digitally generated three-dimensional representations to be integrated with real environmental stimuli. AR can make use of smart phones,..

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Debates in cardiac CT: Coronary CT angiography is the best test in asymptomatic patients

Abstract Cardiovascular disease remains a major cause of mortality, accounting for a third of all global deaths annually. Although there have been major improvements in our ability to detect and..

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Paraprotein associated heparin resistance during cardiopulmonary bypass

Abstract Introduction Heparin resistance during cardiopulmonary bypass poses a significant intraoperative dilemma. Antithrombin deficiency related heparin resistance is well described, but less common causes are still poorly understood and inadequately..

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Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition

Abstract Objectives Intra-device thrombosis remains one of the most common complications during extracorporeal membrane oxygenation (ECMO). Despite anticoagulation, approximately 35% of patients develop thrombi in the membrane oxygenator, pump heads,..

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Venoarterial Extracorporeal Membrane Oxygenation in Severe Drug Intoxication: A Retrospective Comparison of Survivors and Nonsurvivors

Abstract Selecting patients most likely to benefit from venoarterial extracorporeal membrane oxygenation (V-A ECMO) to treat refractory drug-induced cardiovascular shock remains a difficult challenge for physicians. This study reported short-term..

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Epidemiology of persistent postoperative opioid use after cardiac surgery: a systematic review and meta-analysis

Abstract Background The epidemiology of persistent postoperative opioid use at least 3 months after cardiac surgery is poorly characterised despite its potential public health importance. Methods We searched MEDLINE, Embase,..

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Titrated versus conventional anticoagulation management for thrombin generation in cardiac surgery: a randomized controlled trial

Abstract Purpose Optimal heparin titration during cardiopulmonary bypass (CPB) may reduce coagulation system activation and preserve hemostatic function post-CPB. Our objective was to assess if the Heparin Management System (HMS)..

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Implementing Root Cause Analysis and Action: Integrating Human Factors to Create Strong Interventions and Reduce Risk of Patient Harm

Abstract Objectives  The goal of this study was to develop a systems approach for root cause analysis and action to achieve strong, sustainable interventions. The team integrated human factors principles into the..

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Venting during venoarterial extracorporeal membrane oxygenation

Abstract Cardiogenic shock and cardiac arrest contribute pre-dominantly to mortality in acute cardiovascular care. Here, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has emerged as an established therapeutic option for patients suffering..

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Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients…

Abstract Importance  Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than..

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Hemoperfusion in the intensive care unit

Abstract Multiple organ failure following a septic event derives from immune dysregulation. Many of the mediators of this process are humoral factors (cytokines), which could theoretically be cleared by direct..

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The HeartMate 6

Abstract The need for biventricular support poses significant challenges for patients who require a mechanical bridge to transplantation. Recent improvements in ventricular assist device (VAD) technology has made possible the..

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Perioperative Management of Bleeding and Transfusion for Lung Transplantation

Abstract Perioperative allogeneic blood product transfusion is common in lung transplantation and has various implications on the short- and long-term outcomes of lung recipients. This review summarizes the effect of..

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Management of perioperative bleeding risk in patients on antithrombotic medications undergoing cardiac surgery—a systematic review

Abstract Background: Antithrombotic drugs increase the risk of bleeding, especially in patients who need urgent surgery without an adequate wash-out period. This review aims to evaluate perioperative bleeding complications in..

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Survival and Factors Associated with Survival with Extracorporeal Life Support During Cardiac Arrest: A Systematic Review and Meta-Analysis

Abstract The survival rate after cardiac arrest (CA) remains low. The utilization of extracorporeal life support is proposed to improve management. However, this resource-intensive tool is associated with complications and..

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EVALUATING INTERFACILITY ECMO TRANSFER OUTCOMES BY CANNULATION LOCATION AND MODE OF TRANSPORT

Abstract A study published in March 2022 evaluated complications and in-hospital mortality in patients treated with Venovenous (VV) ECMO based on cannula locations and transport mode. The manuscript, written by..

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Impact of cardiopulmonary bypass duration on efficacy of fibrinogen replacement with cryoprecipitate compared with fibrinogen concentrate: a post hoc analysis…

Abstract Background Coagulopathy in cardiac surgery is frequently associated with acquired hypofibrinogenaemia, which can be treated with either purified fibrinogen concentrate (FC) or cryoprecipitate. Because the latter is not purified..

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Recent advancements in pediatric cardiopulmonary bypass technology for better outcomes of pediatric cardiac surgery

Abstract Background Pediatric cardiac surgery is in itself very enigmatic and individualized. Presently, there has been a slew of new developments aimed primarily toward pediatric cardiopulmonary bypass for safer, patient-centered..

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Incidence and outcome of anaphylaxis in cardiac surgical patients

Abstract Introduction:  Anaphylaxis is a rare but serious and potentially fatal complication of anesthesia. Little is known about the incidence and outcome of anaphylaxis in cardiac surgical patients, which we..

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Awake extracorporeal life support and physiotherapy in adult patients: A systematic review of the literature

Abstract Objective The Awake Extracorporeal Life Support (ECLS) practice combined with physiotherapy is increasing. However, available evidence for this approach is limited, with unclear indications on timing, management, and protocols...

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