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Molecules, Machines, and the Perfusate Milieu: Organ Preservation and Emerging Concepts for Heart Transplant

Abstract Heart transplant remains the most durable treatment for end-stage congestive heart failure. Since the first successful human heart transplant performed by Barnard in 1967, advances in organ procurement, understanding..

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The use and effectiveness of high-fidelity simulation in health professions education: current update

Abstract Over the past 10 years, there has been an increase in the use of high-fidelity simulation (HFS) as a tool to support and enhance learning in health profession programs. In..

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Extracorporeal cardiopulmonary resuscitation in adults and children: A review of literature, published guidelines and pediatric single-center program building experience

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) is an adjunct supportive therapy to conventional cardiopulmonary resuscitation (CCPR) employing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in the setting of refractory cardiac arrest. Its use..

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The effect of arterial cannula tip position on differential hypoxemia during venoarterial extracorporeal membrane oxygenation

Abstract Interaction between native ventricular output and venoarterial extracorporeal membrane oxygenation (VA ECMO) flow may hinder oxygenated blood flow to the aortic arch branches, resulting in differential hypoxemia. Typically, the..

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Parameters associated with successful weaning of veno‑arterial extracorporeal membrane oxygenation: a systematic review

Abstract Purpose: Veno‑arterial (VA) extracorporeal membrane oxygenation (ECMO) can be used to restore organ perfusionin patients with cardiogenic shock until native heart recovery occurs. It may be challenging, however, to..

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A Comparison of Separate Access versus In-Line Configuration for Continuous Renal Replacement Therapy in VV ECMO

Abstract Objective Continuous renal replacement therapy (CRRT) in patients receiving venovenous extracorporeal membrane oxygenation (VV ECMO) can be accessed via separate venous access (SVA) or directly “in-line” within the ECMO circuit...

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Hyperoxia and traumatic brain injury: time to stop cooking the books?

Abstract The excellent work by Rezoagli [1] on behalf of the CENTER-TBI and OxENTER-TBI consortia contributes further evidence of the potentially harmful effects of hyperoxia after traumatic brain injury (TBI)...

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Intraoperative Transesophageal Echocardiographic Detection of a Gerbode Defect in a Patient Referred for Aortic Valve Endocarditis: A Case Report

Abstract This clinical challenge discusses a case in which a patient was referred for aortic valve repair or replacement due to severe aortic regurgitation from infective endocarditis. In addition to..

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Implanting de Syncardia TAH-t

Similar to a heart transplant, the SynCardia temporary Total Artificial Heart (TAH-t) replaces both ventricles and the four heart valves.

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Cell Salvage at the ICU

Abstract Patient Blood Management (PBM) is a patient-centered, systemic and evidence-based approach. Its target is to manage and to preserve the patient’s own blood. The aim of PBM is to..

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Coagulation and Transfusion Updates From 2021

Abstract 2021 and the COVID 19 pandemic have brought unprecedented blood shortages worldwide. These deficits have propelled national efforts to reduce blood usage, including limiting elective services and accelerating Patient..

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Intraoperative blood collection without fluid replacement for cardiac surgery – A retrospective analysis

Abstract Background: Transfusion rates in cardiac surgery are high. Aim: To determine if intraoperative autologous blood removal without volume replacement is associated with fewer homologous blood transfusions without increasing acute kidney injury...

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Definition and Classification of Postoperative Complications After Cardiac Surgery: Pilot Delphi Study

Abstract Background: Postoperative complications following cardiac surgery are common and represent a serious burden to health services and society. However, there is a lack of consensus among experts on what..

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Perioperative Circulatory Support and Management for Lung Transplantation: A Case-Based Review

Abstract Lung transplantation (LTx) historically was performed with cardiopulmonary bypass (CPB) or Off-pump. Recent data suggest an increased interest in extracorporeal membrane oxygenation (ECMO) as perioperative circulatory support by many..

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The International Code of Medical Ethics of the World Medical Association

Abstract One of the central missions of the World Medical Association (WMA) in its role as the global organization of physicians is to ensure the highest possible standard of ethical..

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Procoagulant platelets: novel players in thromboinflammation

Abstract Platelets play a key role in maintaining hemostasis. However, dysregulated platelet activation can lead to pathological thrombosis or bleeding. Once a platelet gets activated, it will either become an..

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Why identifying adverse events in paediatric emergency care matters

Abstract The emergency department (ED) abounds with hazards that might lead to adverse events (AEs). Clinicians must make frequent, high-consequence decisions with high diagnostic uncertainty as part of ad hoc..

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Initial hospital length of stay and long-term survival of patients successfully resuscitated using extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac…

Abstract Aims The long-term outcomes of patients treated with extracorporeal cardiopulmonary resuscitation (ECPR) for refractory ventricular tachycardia/ventricular fibrillation (VT/VF) out-of-hospital cardiac arrest (OHCA) remain poorly defined. The purpose of this..

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Creating blood conservation for a cardiothoracic surgical hospital: when you have to start from scratch

Abstract Background: This improvement report presents a hospital blood-management programme, a hospital-specific model that differs from patient blood managment and was aimed at improving operational standards of transfusion. We identified..

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Health-related quality of life, one-year costs and economic evaluation in extracorporeal membrane oxygenation in critically ill adults

Abstract Purpose: This study reports on survival and health related quality of life (HRQOL) after extracorporeal membrane oxygenation (ECMO) treatment and the associated costs in the first year. Materials and..

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Expanding neonatal ECMO criteria: When is the premature neonate too premature

Abstract Extracorporeal membrane oxygenation (ECMO) is a universally accepted and life-saving therapy for neonates with respiratory or cardiac failure that is refractory to maximal medical management. Early studies found unacceptable..

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Heparin Versus Bivalirudin for Anticoagulation in Adult Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) poses unique thrombotic and hemorrhagic risks, and the optimal anticoagulant choice is unknown. We systematically searched Ovid EBM Reviews, Ovid Embase, Ovid Medline, Scopus, and..

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Early and long-term results of ventricular septal defect repair in children with severe pulmonary hypertension and elevated pulmonary vascular resistance…

Abstract   OBJECTIVES In upper-income countries, infants undergo low-risk ventricular septal defect (VSD) repair. Children in low- and middle-income countries frequently present at older ages with elevated pulmonary vascular resistance..

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Cardiac Surgery Unit Advanced Life Support Training

Abstract Background  Although the body of knowledge related to Cardiac Surgery Unit Advanced Life Support (CSU-ALS) guideline has grown over the last 10 years, there is no existing literature examining..

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FLOW PATTERNS OF BLOOD POST APPLICATION OF CROSS CLAMP DURING CARDIOPULMONARY BYPASS

Abstract Cardiopulmonary bypass (CPB) is a common procedure carried out to provide a fluid free and motionless work field at the time of cardiac surgical procedures. To achieve CPB, cannulation..

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Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life…

Abstract Background Acute brain injury (ABI) remains common after extracorporeal cardiopulmonary resuscitation (ECPR). Using a large international multicenter cohort, we investigated the impact of peri-cannulation arterial oxygen (PaO2) and carbon..

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Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study

Abstract Purpose The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults..

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Knowledge gaps and research priorities in adult veno‑arterial extracorporeal membrane oxygenation: a scoping review

Abstract Purpose: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods: An expert panel was recruited consisting of eight..

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