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Optimal Settings at Initiation of Veno-Venous Extracorporeal Membrane Oxygenation: An Exploratory In-Silico Study

Abstract The Extracorporeal Life Support Organisation (ELSO) recommends initiating veno-venous extracorporeal membrane oxygenation (ECMO) with sweep gas flow rate (V˙sweep) of 2 L/min and extracorporeal circuit blood flow (Q˙ec) of 2 L/min...

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The Impact of Electronic Health Record Interoperability on Safety and Quality of Care in High-Income Countries: Systematic Review

Abstract Background:Electronic health records (EHRs) and poor system interoperability are well-known issues in the use of health information technologies in most high-income countries worldwide. Despite the abundance of literature exploring..

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Racial Disparities in Occult Hypoxemia and Clinically Based Mitigation Strategies to Apply in Advance of Technological Advancements

Abstract BACKGROUND: Pulse oximetry is the mainstay of patient oxygen monitoring. Measurement error from pulse oximetry is more common for those with darker skin pigmentation, yet this topic remains understudied, and..

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One-Year Mental and Physical Health Assessment in Survivors After ECMO for COVID-19-related ARDS

Abstract Rational. Long-term outcomes of patients with COVID-19-related acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO) are unknown. Methods. Multicenter, prospective study in patients who received ECMO..

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The effect of Del Nido versus custodiol cardioplegia on clinical outcomes and troponin-I changes among pediatrics with tetralogy of fallot…

Abstract Background Myocardial protection during operations with cardiopulmonary bypass (CPB) and aortic cross clamping is vital. For this purpose, Del Nido (DN) and Custodiol cardioplegia (CC) solutions are used for..

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Crisis Preparedness: A Systems-Based Framework for Avoiding Harm in Surgery

Abstract BACKGROUND:  Highly performing healthcare organizations benefit from robust failure management systems. This involves the ability to respond and recover from critical events, as well avoiding harm in the first..

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Climate responsibilities in intensive care medicine—let’s go green! An introduction to a new series in Intensive Care Medicine

Abstract Alongside species mass extinction and biodiversity loss, climate change signifies humanity’s burdened entry into the Anthropocene []. During the past two centuries, humanity has burned increasing amounts of fossil..

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AMIA’s code of professional and ethical conduct 2022

Abstract AMIA has a longstanding interest and a professional obligation to promote a strong ethical framework for its members and the field of biomedical and health informatics. This white paper..

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Feasibility of using the ProtekDuo cannula in V-P ECMO and PROpella configurations during ground and air transport

Abstract Introduction: Use of the ProtekDuo cannula has been described for right ventricular assist devices (RVADs) and extracorporeal membrane oxygenation (ECMO) systems. Case report: We describe remote cannulation and transport of two..

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Fractured Right Atrial-Pulmonary Artery Cannula (ProtekDuo) in a 164-Day Extracorporeal Membrane Oxygenation Bridge to Lung Transplant

Abstract Fractures of extracorporeal membrane oxygenation (ECMO) cannulas are exceedingly rare due to their woven metal reinforcement. There are only a few cases reported in the literature. We present a 27-year-old..

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An Intensivist-Led Extracorporeal Membrane Oxygenation Program: Design, Implementation, and Outcomes of the First Five Years

Abstract We describe the development, implementation, and outcomes of an intensivist-led adult extracorporeal life support (ECLS) program using intensivists both to perform venovenous (V-V), venoarterial (V-A), and extracorporeal cardiopulmonary resuscitation..

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Retrospective Analysis of Arterial Carbon Dioxide Level and Arterial pH Level at the Time of Initiation of Respiratory ECMO and…

Abstract Introduction  Respiratory extracorporeal membrane oxygenation (ECMO) is well established and its popularity has increased during coronavirus disease 2019 (COVID-19) time. The efficacy of ECMO has been proved in refractory..

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Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation

Abstract OBJECTIVES:  Prone positioning and venovenous extracorporeal membrane oxygenation (ECMO) are both useful interventions in acute respiratory distress syndrome (ARDS). Combining the two therapies is feasible and safe, but the..

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Outcome of extracorporeal membrane oxygenation use in severe accidental hypothermia with cardiac arrest and circulatory instability: A multicentre, prospective, observational…

Abstract Aim To elucidate the effectiveness of extracorporeal membrane oxygenation (ECMO) in accidental hypothermia (AH) patients with and without cardiac arrest (CA), including details of complications. Methods This study was..

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Enabling the control of reperfusion parameters in out-of-hospital cardiac arrest: First applications of the CARL system

Abstract Introduction There is increasing evidence for extracorporeal cardiopulmonary resuscitation (ECPR) as a rescue therapy for selected patients in refractory cardiac arrest (CA). Besides patient selection, the control of reperfusion..

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Parallel circuits for refractory hypoxemia on venovenous extracorporeal membrane oxygenation

Abstract Refractory hypoxemia during support on venovenous (VV) extracorporeal membrane oxygenation (ECMO) is a challenging clinical problem. Manipulating ventilator settings, prone positioning, optimizing cannula position, and ECMO flows, and the..

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Hybrid and parallel extracorporeal membrane oxygenation circuits

Abstract Extracorporeal membrane oxygenation (ECMO) is one type of extracorporeal life support for patients with cardiopulmonary failure. ECMO may serve as a as bridge to recovery, long-term mechanical support, or..

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The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review

Abstract Objective: Assessment of the results of the ProtekDuo cannula applied for dedicated right ventricular support with oxygenator in ARDS secondary to COVID-19. Methods: Systematic literature search in NHS library,..

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Ultra‑lung‑protective ventilation and biotrauma in severe ARDS patients on veno‑venous extracorporeal membrane oxygenation: a randomized controlled study

Abstract Background: Ultra‑lung‑protective ventilation may be useful during veno‑venous extracorporeal membraneoxygenation (vv‑ECMO) for severe acute respiratory distress syndrome (ARDS) to minimize ventilator‑induced lunginjury and to facilitate lung recovery. The objective..

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Blood flow but not cannula positioning influences the efficacy of Veno-Venous ECMO therapy

Abstract Despite being vital in treating intensive-care patients with lung failure, especially COVID-19 patients, Veno-Venous Extra-Corporeal Membrane Oxygenation does not exploit its full potential, leaving ample room for improvement. The..

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Medical Nutrition Therapy in ECMO Patients: Evidence-Based Guidance for Clinical Practice

Abstract Patients receiving extracorporeal membrane oxygenation (ECMO) inherit substantial disease-associated metabolic, endocrinologic, and immunologic modifications. Along with the technical components of ECMO, the aforementioned alterations may affect patients’ needs and..

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Surgical Experience With Crossed and Anomalous Origin of the Pulmonary Arteries From the Pulmonary Trunk: A Single Center Report of…

Abstract Anomalies of the pulmonary origin of the pulmonary arteries are uncommon; however, the true incidence is unknown and may be underestimated. We sought to review our experience with this..

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Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model

Abstract Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal..

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Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and…

Abstract Objectives:  To determine the effect of intraoperative antifibrinolytics, including tranexamic acid (TXA), aminocaproic acid (EACA), or aprotinin, on bleeding in children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Data..

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Colloid Film in Optimized Extracorporeal Circulation: “A Possible Road for the Extinction of Miniaturized Cardiopulmonary Bypass”.

Abstract The inflammatory response in cardiac surgery using extracorporeal circulation (ECC) has been widely discussed in the literature with analysis on cytokines released in humans. To mitigate this response mainly..

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Anti-thrombotic Therapy with Cangrelor and Bivalirudin in Venoarterial Extracorporeal Membrane Oxygenation Patients Undergoing Percutaneous Coronary Intervention: A Single-Center Experience

Abstract VA-ECMO is commonly used for patients in cardiogenic shock (CS) or refractory cardiac arrest (CA) undergoing PCI for ACS. In this setting at high risk of both thrombotic and..

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Hemocompatibility challenge of membrane oxygenator for artificial lung technology

Abstract The artificial lung (AL) technology is one of the membrane-based artificial organs that partly augments lung functions, i.e. blood  and CO2 removal. It is generally employed as an extracorporeal membrane  (ECMO) device to..

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Clinical Trials Design, Scientific Rigor, and Higher-Level Evidence in Surgery

Abstract There is a perception held by others in the health sciences that surgeons are not adequately assessing surgical procedures. In an Editorial in the Lancet in 1996, entitled, “Surgical Research or..

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Recurrent Candidemia Due to Extracorporeal Membrane Oxygenation Circuit Seeding in Acute Respiratory Distress Syndrome From COVID-19

Abstract Nosocomial infections are a leading complication of prolonged extracorporeal membrane oxygenation (ECMO) therapy, and invasive fungal infections are of particular concern. Candida bloodstream infection specifically is associated with poor outcomes in acute..

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Association of low mixed venous oxygen saturations during early ICU stay with increased 30-day and 1-year mortality after cardiac surgery:…

Abstract Background Low postoperative mixed venous oxygen saturation (SvO2) values have been linked to poor outcomes after cardiac surgery. The present study was designed to assess whether SvO2 values of < 60%..

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