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Lactic alkalosis in a patient on veno-venous extracorporeal membrane oxygenation: A case report

Abstract Background: Lactic alkalosis, defined as an increase in circulating lactate in the setting of elevated extracellular pH, has been described in both in vivo and in vitro settings, often..

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Novel Use of a Distal Perfusion Catheter With a Removable Side Port in Patients on VA-ECMO

Abstract Risk of limb ischemia in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) is minimized with the use of distal perfusion catheters (DPCs). However, conventional sheaths utilize a flow-limiting side..

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Cost-effectiveness of extracorporeal CPR for out-of-hospital cardiac arrest: a trial-based Markov model with a lifetime horizon

Abstract Aims Extracorporeal cardiopulmonary resuscitation (ECPR) can restore circulation in refractory out-of-hospital cardiac arrest (OHCA). A trial-based analysis with a 1-year horizon showed limited cost-effectiveness of this demanding procedure. However,..

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The Year in Coagulation and Transfusion: Selected Highlights

Abstract The past year has yielded important advances in coagulation and transfusion practice across cardiothoracic and vascular care. Patient blood management remains central, with growing evidence supporting restrictive transfusion thresholds,..

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Cardiac surgery in Chile: preoperative risk characterization and analytical outcomes pre-operative risk characterization in cardiac surgeries

Abstract Background Cardiovascular diseases are the leading cause of mortality worldwide, including in Chile, accounting for about 23% of all deaths. Advanced cardiac surgical procedures like coronary artery bypass grafting..

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Oxygenator oxygen transfer performance during cardiopulmonary bypass of the Sorin® Inspire 6F©

Abstract Background Oxygenator oxygen transfer performance is typically measured by manufacturers under standardized, static laboratory conditions. However, these parameters do not adequately reflect the dynamic environment of clinical cardiopulmonary bypass..

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Quantitative Electroencephalogram Patterns During Neonatal Antegrade Cerebral Perfusion and Deep Hypothermic Circulatory Arrest that Suggest Neurologic Injury

Abstract During cerebral ischemia, the quantitative Electroencephalogram (EEG) Alpha: Delta Ratio (ADR) decreases, and the asymmetry percentage increases. The utility of analyzing these metrics during neonatal Antegrade Cerebral Perfusion (ACP)..

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Guiding complexity in V-A ECMO weaning decisions for cardiogenic shock: Insights from a conjoint analysis

Abstract Weaning and liberation from V-A ECMO for cardiogenic shock involves complex decision-making that requires balancing multiple clinical parameters. In the absence of specific weaning guidelines, ECMO centers rely on..

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Heparin Exposure Adjustment to Reduce Thrombo-hemorrhagic Complications After Venoarterial Extracorporeal Membrane Oxygenator Cannulation: The HEART-ECMO Observational Cohort Study

Abstract Objectives Hemorrhagic complications remain a major concern in patients with cardiogenic shock and extracorporeal cardiopulmonary resuscitation. The purpose of this study was to assess the effect of withholding a..

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Oxygenator-related gaseous microemboli and postoperative delirium after on-pump coronary artery bypass grafting: a prospective cohort study

Abstract Background The increasing preference for off-pump coronary artery bypass grafting (CABG) reflects efforts to reduce complications associated with cardiopulmonary bypass (CPB). A lower incidence of postoperative delirium (POD) after..

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Clinical characterization of membrane oxygenator exhaust capnometry during venovenous extracorporeal membrane oxygenation

Abstract Capnometry is a cost-efficient method of monitoring carbon dioxide (CO2) in healthcare settings, especially during mechanical ventilation and cardiopulmonary bypass. However, the utility of capnometers for studying CO2 elimination in..

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Avoidance of Hyperoxemia Versus Routine Hyperoxia During Cardiopulmonary Bypass in Children With Cyanotic Congenital Heart Disease—A Systematic Review and Meta-Analysis

Abstract Background Children with cyanotic congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass (CPB) are exposed to varying oxygenation strategies, and the optimal oxygenation strategy and the impact of..

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Comparison of intermittent antegrade cardioplegia and antegrade/retrograde cardioplegia in cardiac surgery: A propensity-matched analysis

Abstract Background The aim of this study is to compare the clinical results of intermittent antegrade and intermittent antegrade/continuous retrograde cardioplegia techniques in patients undergoing cardiac surgery. Methods Between 2023..

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Outcomes and prediction of mortality in patients requiring prolonged veno-arterial extracorporeal membrane oxygenation support in the PRECISE-ECLS observational study

Abstract Background Veno-arterial ExtraCorporeal Membrane Oxygenation (V-A ECMO) as a bridge to recovery or long-term assist devices in severe cardiocirculatory failure typically lasts 5–7 days. There is scarce guidance on..

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Next-generation extracorporeal membrane oxygenation for multi-organ recovery after refractory cardiac arrest

Abstract Introduction: Survival after cardiac arrest and prolonged conventional cardiopulmonary resuscitation remains poor, with out-of-hospital survival rates of only 2%–10%. Conventional veno-arterial extracorporeal membrane oxygenation or extracorporeal cardiopulmonary resuscitation can restore..

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Volatile Anesthesia in Contemporary Cardiac Surgery: Clinical Implications, Organ Protection and Perspectives for Personalized Perioperative Care

Abstract Background: Interest in inhalational anesthesia in cardiac surgery has resurged as volatile anesthetics exert biological effects extending beyond hypnosis. Sevoflurane and desflurane activate mitochondrial cytoprotective signaling pathways, modulate inflammatory..

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Exploring weaning-related shock: Cardiac injury and overload, platelet-endothelial cell activation, and inflammatory response markers following ECMO decannulation

Abstract Introduction Mortality in patients receiving Extracorporeal Membrane Oxygenation (ECMO) is partly attributable to unanticipated hemodynamic instability after elective decannulation, termed weaning-related shock (WRS). This study explored the etiology of..

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Early Prediction of Postoperative Peritoneal Dialysis Using Lung Ultrasound Scoring in Neonates After Cardiopulmonary Bypass

Abstract Background: Neonates and young infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) are highly vulnerable to pulmonary dysfunction, systemic inflammation, capillary leak, and fluid overload, which may lead to..

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Unexpected Cardiac Arrest After Cardiopulmonary Bypass Initiation, Likely Due to Cardioplegia Migration: A Case Report

Abstract This case report describes a pediatric cardiac surgery in which electrocardiographic (ECG) changes appeared immediately after the initiation of cardiopulmonary bypass (CPB), followed by severe bradycardia and ultimately flaccid..

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Subclavian or axillary artery cannulation for extracorporeal membrane oxygenation: A systematic review

Abstract Background Subclavian or axillary artery cannulation for venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides a valuable alternative to femoral access; however, a comprehensive overview of such an approach in this..

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Normoxic versus hyperoxic reperfusion: A retrospective study of ischemia–reperfusion injury in patients undergoing on-pump coronary artery bypass grafting

Abstract Background Blood oxygen content and management during cardiopulmonary bypass (CPB), particularly during reperfusion phase after cross-clamping related ischemia, may influence systemic oxygen utilization, oxidative stress, and organ ischemia/reperfusion injury...

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Prevention and management of nosocomial infections in patients undergoing extracorporeal membrane oxygenation: a summary of best evidence

Abstract Purpose This study aimed to systematically search, evaluate, and synthesize the latest evidence on the prevention and management of nosocomial infections in patients supported by extracorporeal membrane oxygenation. Methods..

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Correlations between intraparenchymal cerebral temperature and peripheral temperature monitoring sites during rewarming after deep hypothermic circulatory arrest on cardiopulmonary bypass

Abstract Background Optimal anatomical sites for temperature monitoring that most closely correlates with cerebral temperature remain debated in cardiac surgery, particularly during cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest..

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Left Ventricular Venting Using a Transaortic Pigtail Catheter in Pediatric Myocarditis Requiring Extracorporeal Membrane Oxygenation

Abstract Patients with fulminant myocarditis accompanied by severe hemodynamic deterioration, cardiogenic shock, or refractory arrhythmias often require venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment. When left ventricular (LV) dilation, elevated LV..

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Ventilator management on extracorporeal membrane oxygenation: considerations for open lung strategy

Abstract Purpose of review  The present review addresses the underlying biology of acute respiratory distress syndrome (ARDS) while recognizing that extracorporeal membrane oxygenation (ECMO) is an increasingly employed technology in..

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The invisible face of ECMO: anxiety levels and challenges among intensive care nurses

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a technology that provides temporary life support to critically ill patients with heart and/or lung failure. However, the complexity of the care involved..

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Design and rationale of the Impella®-protected cardiac surgery trial (IMPACT): A multicenter, single-arm pilot study in high-risk cardiac surgery patients

Abstract Background Cardiac surgery patients with severe preoperative left ventricular (LV) dysfunction are at high risk for poor postoperative outcomes including prolonged ventilation, renal failure and post-cardiotomy cardiogenic shock (PCCS)...

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Impact of Priming Volume Reduction on Hematocrit Retention in Pediatric Cardiopulmonary Bypass: A Retrospective Analysis

Abstract Background Retrograde autologous priming and venous antegrade priming replace the cardiopulmonary bypass circuit crystalloid with patient blood to mitigate hemodilution. However, their effectiveness in pediatric patients, particularly when analyzed..

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Heterogeneity of Treatment Effect for Intra-Aortic Balloon Pump Use Across Lactate Trajectories in Cardiogenic Shock Patients Supported by VA-ECMO: An…

Abstract This study aimed to investigate the heterogeneity of treatment effect for intra-aortic balloon pump (IABP) across various lactate trajectories in patients with acute myocardial infarction-related cardiogenic shock (AMICS) supported..

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Ischemic and hemorrhagic stroke in pediatric patients after extracorporeal membrane oxygenation decannulation: a systematic review

Abstract OBJECTIVE Extracorporeal membrane oxygenation (ECMO) is a vital support for pediatric patients with severe cardiac or pulmonary failure. However, post-decannulation complications, particularly involving carotid artery ligation (CAL) or carotid..

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