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Early trends in ECMO mortality during the first quarters of 2019 and 2020: Could we have predicted the onset of…

Abstract Objective To compare mortality trends in patients requiring Extracorporeal Membrane Oxygenation (ECMO) support between the first quarters of 2019 and 2020 and determine whether these trends might have predicted..

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Thematic reviews of patient safety incidents as a tool for systems thinking: a quality improvement report

Abstract Ensuring organisations learn from patient safety incidents is a key aim for healthcare organisations. The role that human factors and systems thinking can have to enable organisations learn from..

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Use of Subclavian Extracorporeal Carbon Dioxide Removal for COVID-19 Acute Respiratory Distress Syndrome as a Bridge to Lung Transplantation

Abstract Severe acute hypercapnia is independently associated with increased adverse effects and intensive care unit mortality in mechanically ventilated patients. During the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic,..

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Calcium Channel Blocker Overdose: What Role Does Extracorporeal Membrane Oxygenation Have in Support? A Systematic Review of the Literature

Abstract Extracorporeal membrane oxygenation (ECMO) has had increasing prevalence and indications in the last decade. Calcium channel blocker overdose (CCBOD) can lead to significant cardiopulmonary dysfunction and has also increased..

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Using the Anesthetic Gas Filter CONTRAfluran While on Cardiopulmonary Bypass: Preliminary Study of the Feasibility, Security, and Efficiency

Abstract The 2 hypnotic agents currently used for the maintenance of general anesthesia during cardiopulmonary bypass (CPB) are propofol and sevoflurane. Propofol can be administered directly into the cardiotome of..

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Influence of minimal invasive extracorporeal circuits on dialysis dependent patients undergoing cardiac surgery

Abstract Introduction Cardiac surgery in patients on chronic renal dialysis is associated with significant morbidity and mortality. Minimally invasive extracorporeal circuits (MiECC) have shown a positive impact on patient outcome..

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Hyperoxia Increases Kidney Injury During Renal Ischemia and Reperfusion in Mice

Abstract BACKGROUND:  Renal ischemia and reperfusion (IR) contribute to perioperative acute kidney injury, and oxygen is a key regulator of this process. We hypothesized that oxygen administration during surgery and..

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The incidence, risk factors and outcomes of impaired cerebral autoregulation in aortic arch surgery: a single-center, retrospective cohort study

Abstract Background Impairment of cerebral autoregulation (CA) has been observed in patients undergoing cardiopulmonary bypass (CPB), but little is known about its risks and associations with outcomes. The cerebral oximetry..

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Association of body mass index with perioperative blood transfusion and short-term clinical outcomes in patients undergoing isolated coronary artery bypass…

Abstract Background Few studies have considered outcomes among low body mass index (BMI) cohorts undergoing coronary artery bypass grafting (CABG). This study aims to investigate the effects of low body..

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Perioperative prophylactic corticosteroids for cardiac surgery in children: A systematic review and meta-analysis

Abstract Objective Perioperative corticosteroids have been used for  cardiac surgery for decades, but the underlying evidence is conflicting. We aimed to investigate the efficacy and safety of perioperative prophylactic corticosteroids in  heart..

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Machine learning for dynamic and early prediction of acute kidney injury after cardiac surgery

Abstract Objective  after cardiac surgery increases morbidity and mortality. Diagnosis relies on  or increased serum creatinine, which develop 48 to 72 hours after injury. We hypothesized machine learning incorporating preoperative, operative, and  data..

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Perioperative Environment Safety Culture

Abstract Improving the safety of patient care is a top priority in the perioperative environment in order to minimize preventable deaths, post-surgical complications, and preventable adverse events.   Improved protocols..

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Handgrip exercise in patients scheduled for cardiac surgery to attenuate troponin release: a feasibility study

Abstract Cardiac surgery, including surgical aortic valve repair (SAVR) and coronary artery bypass grafting (CABG), are associated with ischemia-reperfusion (I/R) injury. Single bouts of exercise, including handgrip exercise, may protect..

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The impact of extracorporeal membrane oxygenation on antifungal pharmacokinetics: A systematic review

Abstract Background and Objective The use of extracorporeal membrane oxygenation (ECMO) as a cardiocirculatory or respiratory support has tremendously increased in critically ill patients. In the setting of ECMO support,..

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Methemoglobinemia: A Case Study During ECMO

Abstract Methemoglobinemia is a rare blood disorder that can have severe consequences if not promptly diagnosed and treated. In this article, we will explore a real-life case study of a..

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Survival and Long-Term Functional Status of COVID-19 Patients Requiring Prolonged ECMO Support

Abstract Rationale Severe cases of acute respiratory distress syndrome (ARDS) may require prolonged (>28 days) extracorporeal membrane oxygenation (ECMO). In non-resolving disease, recovery is uncertain and lung transplant may be..

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Comparison of six percent hydroxyethyl starch 130/0.4 and ringer’s lactate as priming solutions in patients undergoing isolated open heart valve…

Abstract Objectives Colloids are added to the priming solution of the cardiopulmonary bypass (CPB) pump to maintain colloid osmotic pressure and prevent fluid overload. This study aimed to compare the..

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Mechanical circulatory support in cardiogenic shock

Abstract Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment of cardiogenic shock is to improve abnormal hemodynamics and maintain adequate..

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An In-Depth Analysis of the Multi-Faceted Benefits of Cytosorb Filter Utilization during Cardiopulmonary Bypass

Abstract Introduction: Cardiopulmonary bypass (CPB) is a vital component of many cardiac surgeries, but it can trigger systemic inflammatory responses, leading to post-operative complications. The CytoSorb filter, a cytokine adsorber, has..

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Depth of anesthesia, temperature, and postoperative delirium in children and adolescents undergoing cardiac surgery

Abstract Background After pediatric cardiosurgical interventions, postoperative delirium can occur, which can be associated with undesirable consequences during and after the hospital stay. It is therefore important to avoid any..

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Albumin and Cardioprotection in On-Pump Cardiac Surgery—A Post Hoc Analysis of a Randomized Trial

Abstract Objectives To study the quantitative potency of plasma albumin on cardioprotection in terms of creatinine kinase-myocardial band mass (CK-MBm) in on-pump cardiac surgery. Design Post hoc analysis of a..

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Cardiopulmonary Bypass Surgery-Cold Alert!

Abstract The term “cold agglutinin (CA)” refers to a group of disorders caused by anti-erythrocyte autoantibodies that preferentially bind RBCs at cold temperatures (4°C–18°C). CAs contribute to 10 to 15%..

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Does heparin rebound lead to postoperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass?

Abstract Background Heparin rebound is a common observed phenomenon after cardiac surgery with CPB and is associated with increased postoperative blood loss. However, the administration of extra protamine may lead..

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Successful Prehospital Extracorporeal Cardiopulmonary Resuscitation: A Comprehensive Case Report and Analysis of the Current Experience and Knowledge

Abstract This case report describes a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) in a female patient who suffered a sudden cardiac arrest while shopping in a supermarket. The success of this..

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Error traps in Pediatric Patient Blood Management in the Perioperative Period

Abstract Patient blood management is a patient-centered evidence-based approach to improve patient outcomes by harnessing the patient's own hematopoietic system to optimize blood health while promoting patient safety and empowerment...

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Plasma Exosome Hemoglobin Released During Surgery Is Associated With Cardiac Injury in Animal Model

Abstract Background Patients with valvular heart disease require  and cardiac arrest. Here, we test the hypothesis that exosomal hemoglobin formed during  mediates acute cardiac injury in humans and in an animal model..

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Narrative Review of Systemic Inflammatory Response Mechanisms in Cardiac Surgery and Immunomodulatory Role of Anesthetic Agents

Abstract Although surgical techniques and perioperative care have made significant advances, perioperative mortality in cardiac surgery remains relatively high. Single- or multiple-organ failure remains the leading cause of postoperative mortality...

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Balloon atrial septostomy versus left atrial cannulation for left heart decompression in children with dilated cardiomyopathy and myocarditis on extracorporeal…

Abstract Introduction In children with myocarditis or dilated cardiomyopathy (DCM) on extracorporeal membrane oxygenation (ECMO) for cardiogenic shock, it is often necessary to decompress the left heart to minimize distension..

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Acute Kidney Injury after Cardiac Surgery: Prediction, Prevention, and Management

Abstract Acute kidney injury (AKI) is a common complication in cardiac surgery patients, with a reported incidence of 20 to 30%. The development of AKI is associated with worse short-..

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Cardiopulmonary bypass management and risk of new-onset atrial fibrillation after cardiac surgery

OBJECTIVES Cardiopulmonary bypass (CPB) management may potentially play a role in the development of new-onset atrial fibrillation (AF) after cardiac surgery. The aim of this study was to explore this..

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